Children (10–12 years age) of women with epilepsy have lower intelligence, attention and memory: Observations from a prospective cohort case control study

Gopinath, Neelima; Muneer, Anila K.; Unnikrishnan, Syam; Varma, Ravi Prasad; Thomas, Sanjeev V

doi:10.1016/j.eplepsyres.2015.09.003

Cited by 24 publications

(34 citation statements)

References 24 publications

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“…MCM rate in this study from India with low middle income, socioeconomic background and Asian ethnicity is comparable to that reported from elsewhere. It is important to note that antenatal exposure to some of the AEDs is associated with increased risk of impaired cognitive and language development in children of WWE …”

Section: Discussionmentioning

confidence: 99%

“…It is important to note that antenatal exposure to some of the AEDs is associated with increased risk of impaired cognitive and language development in children of WWE. 15 There are about 1.25 million WWE of reproductive age in India. The AEDs and epilepsy care offered to WWE during pregnancy need to be further customized to reduce the risk of MCMs in their babies.…”

Section: Discussionmentioning

confidence: 99%

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Malformation risk of antiepileptic drug exposure during pregnancy in women with epilepsy: Results from a pregnancy registry in South India

et al. 2017

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Malformation risk of antiepileptic drug exposure during pregnancy in women with epilepsy: Results from a pregnancy registry in South India

et al. 2017

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“…Regarding carbamazepine, phenobarbital and topiramate, although experimental studies have not demonstrated any effects 26,32 , increased risks of cognitive and motor disorders have been reported in children exposed prenatally 9,10,13,15,27,[33][34][35] . Our results suggest a possible increased risk of early NDs associated with exposure to carbamazepine and phenobarbital but not with topiramate.…”

Section: Unexposed Childrenmentioning

confidence: 99%

Risk of early neurodevelopmental disorders associated with in utero exposure to valproate and other antiepileptic drugs: a nationwide cohort study in France

Coste

Blotière

Miranda³

et al. 2020

Sci Rep

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Information available on the risks of neurodevelopmental disorders (NDs) associated with in utero exposure to valproate (VPA) and to other antiepileptic drugs (AEDs) is limited. A nationwide population-based cohort study was conducted based on comprehensive data of the French National Health Data System (SNDS). Liveborn infants without brain malformation, born between January 2011 and December 2014, were followed from birth up to December 2016. NDs were identified based on diagnoses of mental or behavioural disorders and utilization of speech therapy, orthoptic or psychiatric services. The risk of NDs was compared between children exposed in utero to AED monotherapy and unexposed children, using Cox proportional hazard models adjusted for maternal and neonatal characteristics. The cohort included 1,721,990 children, 8848 of whom were exposed in utero to AED monotherapy. During a mean follow-up of 3.6 years, 15,458 children had a diagnosis of mental or behavioural disorder. In utero exposure to VPA was associated with an increased risk of NDs overall (aHR: 3.7; 95% CI 2.8–4.9) and among children born to a mother without mental illness (aHR 5.1; 95% CI 3.6–7.3). A dose–response relationship was demonstrated and the risk of NDs was more particularly increased for an exposure to VPA during the second or third trimesters of pregnancy. Among the other AEDs, only pregabalin was consistently associated with an increased risk of NDs (aHR: 1.5; 95% CI 1.0–2.1). This study confirms a four to fivefold increased risk of early NDs associated with exposure to VPA during pregnancy. The risk associated with other AEDs appears much lower.

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“…Other studies have also found dose effects, with higher doses associated with more problems [13,31,36,37,48]. Some studies did not find significant neurocognitive or behavioral problems after prenatal VPA exposure [9, [49][50][51]. These different outcomes may be due to lower doses or small sample sizes.…”

Section: Long-term Neurocognitive and Behavioral Functioning After Prmentioning

confidence: 99%

EURAP & Development: Study Protocol of a Dutch Prospective Observational Study into Fetal Antiepileptic Drug Exposure and Long-term Neurocognitive, Behavioral and Family Outcomes

Huber‐Mollema¹,

Iterson²,

Oort³

et al. 2018

Preprint

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Background: Children exposed to antiepileptic drugs (AEDs) in utero are at higher risk for congenital malformations. Less is known about the long-term association with neurocognition and behavior. Research into family factors related to long-term developmental outcomes of children of women with epilepsy is also rare. We present a protocol to investigate the neurocognitive and behavioral development in children of mothers with epilepsy from a family perspective. Methods: This is a prospective observational longitudinal study, of children exposed in utero to monotherapy carbamazepine, lamotrigine, valproate or levetiracetam whose mother were previously included in the European Registry of Antiepileptic Drugs and Pregnancy (EURAP-NL) database. Children are tested at age six or seven years (T1) and at eight or nine years (T2). Children, mothers and fathers are asked to undergo neuropsychological assessments and to complete questionnaires on behavioral functioning and distinct family factors. Discussion: This study contributes to future counseling of women with epilepsy who have children or wishes to start a family. Strengths are the inclusion of levetiracetam, the longitudinal design, and alongside neurocognition, the inclusion of differential behavioral and family outcome measures. Anticipated limitations are discussed.

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Children (10–12 years age) of women with epilepsy have lower intelligence, attention and memory: Observations from a prospective cohort case control study

Cited by 24 publications

References 24 publications

Malformation risk of antiepileptic drug exposure during pregnancy in women with epilepsy: Results from a pregnancy registry in South India

Malformation risk of antiepileptic drug exposure during pregnancy in women with epilepsy: Results from a pregnancy registry in South India

Risk of early neurodevelopmental disorders associated with in utero exposure to valproate and other antiepileptic drugs: a nationwide cohort study in France

EURAP & Development: Study Protocol of a Dutch Prospective Observational Study into Fetal Antiepileptic Drug Exposure and Long-term Neurocognitive, Behavioral and Family Outcomes

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Children (10–12 years age) of women with epilepsy have lower intelligence, attention and memory: Observations from a prospective cohort case control study

Cited by 24 publications

References 24 publications

Malformation risk of antiepileptic drug exposure during pregnancy in women with epilepsy: Results from a pregnancy registry in South India

Malformation risk of antiepileptic drug exposure during pregnancy in women with epilepsy: Results from a pregnancy registry in South India

Risk of early neurodevelopmental disorders associated with in utero exposure to valproate and other antiepileptic drugs: a nationwide cohort study in France

EURAP &amp; Development: Study Protocol of a Dutch Prospective Observational Study into Fetal Antiepileptic Drug Exposure and Long-term Neurocognitive, Behavioral and Family Outcomes

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Product

Resources

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EURAP & Development: Study Protocol of a Dutch Prospective Observational Study into Fetal Antiepileptic Drug Exposure and Long-term Neurocognitive, Behavioral and Family Outcomes