Background: The present study aims at investigating the relationship between religious coping behaviors and depression in Iranian patients with cancer. Methods: In this cross sectional study (October to December, 2015), 380 patients with cancer, admitted to the associated university's medical sciences hospitals (Sari, Iran), were entered to the present study, using non-random sampling (accessible sampling). Data were collected by demographic questionnaire, center for epidemiological studies depression scale (CES-D), and religious coping questionnaire (RCOPE). The statistical package for social sciences, version 20.0 (SPSS Inc., Chicago, IL, USA) was used for data analysis by descriptive and infernal statistic tests (Spearman's correlation and generalized linear models).