Children of non-Western origin with end-stage renal disease in the Netherlands, Belgium and a part of Germany have impaired health-related quality of life compared with Western children

Schoenmaker, Nikki J.; Haverman, Lotte; Tromp, Wilma F.; Lee, Johanna H. van der; Offringa, Martin; Adams, Brigitte; Bouts, Antonia H.; Collard, Laure; Cransberg, Karlien; Dyck, Maria Van; Godefroid, Nathalie; Hoeck, Koenraad van; Koster-Kamphuis, Linda; Lilien, Marc R.; Raes, Ann; Taylan, Christina; Grootenhuis, Martha A.; Groothoff, Jaap W.

doi:10.1093/ndt/gft436

Cited by 17 publications

(16 citation statements)

References 31 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Educational attainment was categorized according to the highest successfully completed level of schooling: high level (high-level vocational training, “Hoger Beroeps Onderwijs,” “Fachhochschule,” or university) versus intermediate or low level. According to the definition of Statistics Netherlands [ 14 ], children were considered to be non-Western if they themselves or one or both parents had been born outside Western Europe.…”

Section: Methodsmentioning

confidence: 99%

Children on dialysis as well as renal transplanted children report severely impaired health-related quality of life

et al. 2018

View full text Add to dashboard Cite

ObjectivesTo assess health-related quality of life (HRQoL) across three renal replacement therapy modalities (preemptive transplant, non-preemptive transplant, and dialysis) in comparison with the healthy norm and other chronic health conditions, and to explore related patient factors.Study designAll prevalent end-stage renal disease (ESRD) patients aged 8–18 years who spent at least 6 months on their current treatment modality in the Netherlands, Belgium, and part of Germany were approached to complete the Pediatric Quality of Life Inventory 4.0 (PedsQL™) questionnaire. We determined the differences between groups on PedsQL™ mean scores, the proportion of children with an impaired HRQoL (≥ 1 SD lower than the healthy norm), the proportion of problems on individual items of the PedsQL™, and the effect of time on current treatment. Linear regression models were used to explore determinants of HRQoL.Results192 out of 278 patients (20% preemptive transplant, 58% non-preemptive transplant, 22% dialysis) filled in the PedsQL™ (response rate 69%). Independent of treatment modality, patients had significantly lower mean scores and consequently higher proportions of impaired HRQoL on almost all domains compared to the healthy norm and other chronic health conditions. Patients with a preemptive transplant only reported higher scores on physical health compared to the other treatment modalities. Having comorbidities was the most important determinant associated with lower HRQoL scores.ConclusionDialysis and renal transplantation both have a severe impact on the HRQoL of children with ESRD. Physicians should be aware of this continuous burden. Furthermore, to develop tailored interventions for children with ESRD, qualitative studies are needed to gain more insight in the determinants of HRQoL in the different treatment modalities.

show abstract

Section: Methodsmentioning

confidence: 99%

Children on dialysis as well as renal transplanted children report severely impaired health-related quality of life

et al. 2018

View full text Add to dashboard Cite

show abstract

“…As a result, they are vulnerable to a multitude of short- and long-term academic, behavioral, and negative emotional outcomes, such as withdrawn behavior. According to several studies conducted in both Europe and the USA, pediatric ESRD patients have significantly lower HRQoL scores compared with healthy children of the same age, especially concerning physical functioning in those treated by dialysis [11–13, 29, 32, 35]. Furthermore, a study from the USA of 2500 pediatric patients from ten different physician-diagnosed disease clusters [36] found that patients with ESRD had significantly worse HRQoL scores compared to children with other chronic illnesses (including diabetes, cardiac conditions, asthma, and severe obesity) on the PedsQL 4.0 domains of physical health, psychological health, social functioning, and school functioning.…”

Section: Hrqol In Children With Esrdmentioning

confidence: 99%

“…A study conducted in children with ESRD in The Netherlands, Belgium, and part of Germany [35] found that children of non-Western origin were at risk for impaired HRQoL on emotional- and school-functioning domains. Also, low parental level of education may result in a decreased HRQoL in their children's childhood [61], and both patients and parents being part of nonintact households reported lower emotional HRQoL than those from married households [8].…”

Section: Sociodemographic Factorsmentioning

confidence: 99%

Health-related quality of life in patients with pediatric onset of end-stage renal disease: state of the art and recommendations for clinical practice

et al. 2015

View full text Add to dashboard Cite

Health-related quality of life (HRQoL) is increasingly recognized as a key outcome in both clinical and research settings in the pediatric population with end-stage renal disease (ESRD). This review aims to: (1) summarize the current knowledge on HRQoL and socioprofessional outcomes and (2) provide strategies for incorporation of HRQoL assessment into clinical practice. Studies report that pediatric patients with ESRD have significantly lower HRQoL scores compared with children with other chronic diseases. Patients treated by dialysis are at particularly high risk for impaired HRQoL. Furthermore, patients more often have impaired neurocognitive functioning and lower academic achievement. Important determinants of impaired HRQoL include medical factors (i.e., receiving dialysis, disabling comorbidities, cosmetic side effects, stunted growth), sociodemographic factors (i.e., female gender, non-Western background) and psychosocial factors (i.e., noneffective coping strategies). Contrary to the situation in childhood, adult survivors of pediatric ESRD report a normal mental HRQoL. Despite this subjective feeling of well-being, these patients have on average experienced significantly more difficulties in completing their education, developing intimate relationships, and securing employment. Several medical and psychosocial strategies may potentially improve HRQoL in children with ESRD. Regular assessment of HRQoL and neurocognitive functioning in order to identify areas in which therapies and interventions may be required should be part of standard clinical care.

show abstract

“…[10][11][12] A study performed in the Netherlands and Belgium found that children, adolescents, and young adults of non-Western origin were more often treated with hemodialysis instead of peritoneal dialysis and had decreased access to kidney transplantation compared with children, adolescents, and young adults of Western origin. 13,14 However, although the total number of non-Western immigrants in Europe is growing, 15 information for other European countries is lacking. We therefore aimed to assess differences in: (1) access to kidney transplantation, (2) transplant survival, and (3) overall patient survival on RRT between racial groups among children, adolescents, and young adults on RRT in Europe.…”

mentioning

confidence: 99%

Racial Disparities in Access to and Outcomes of Kidney Transplantation in Children, Adolescents, and Young Adults: Results From the ESPN/ERA-EDTA (European Society of Pediatric Nephrology/European Renal Association−European Dialysis and Transplant Association) Registry

Tjaden

Noordzij

Stralen

et al. 2016

American Journal of Kidney Diseases

View full text Add to dashboard Cite

show abstract

Children of non-Western origin with end-stage renal disease in the Netherlands, Belgium and a part of Germany have impaired health-related quality of life compared with Western children

Abstract: Children with ESRD of non-Western origin in three Western countries were found to be at risk for impaired HRQoL on emotional and school functioning. These children warrant special attention.

Cited by 17 publications

References 31 publications

Children on dialysis as well as renal transplanted children report severely impaired health-related quality of life

Children on dialysis as well as renal transplanted children report severely impaired health-related quality of life

Health-related quality of life in patients with pediatric onset of end-stage renal disease: state of the art and recommendations for clinical practice

Racial Disparities in Access to and Outcomes of Kidney Transplantation in Children, Adolescents, and Young Adults: Results From the ESPN/ERA-EDTA (European Society of Pediatric Nephrology/European Renal Association−European Dialysis and Transplant Association) Registry

Contact Info

Product

Resources

About