Children's Oncology Group's 2023 blueprint for research: Renal tumors

Geller, James I.; Hong, Andrew L.; Vallance, Kelly; Evageliou, Nicholas F.; Aldrink, Jennifer H.; Cost, Nicholas G.; Treece, Amy; Renfro, Lindsay A.; Mullen, Elizabeth

doi:10.1002/pbc.30586

Cited by 7 publications

(3 citation statements)

References 120 publications

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“…The current research group, which replaces the National Wilms Tumor Study Group (NWRSG), is the Children's Oncology Group Renal Tumor Committee (COGRTC), adhering to the principles enucleated in the previous description [60].…”

Section: Postoperative Radiationmentioning

confidence: 99%

Wilms Tumor: Updates about Pathogenesis and New Possible Clinical Treatments of the Most Frequent Pediatric Urogenital Cancer: A Narrative Review

Perrotta,

Castellani

2023

Surgeries

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Background: Wilms tumor (or nephroblastoma) is a malignant and solid neoplasm that derives from the primitive renal bud. It represents the most frequent primary tumor of the urogenital tract in childhood, and treatment consists of surgery and chemo-radiotherapy. However, concerning quality of life, the new therapeutic frontier is exploring other safer and potentially more effective options, such as minimally invasive surgery and biological drugs. Method: Literature (PubMed) from January 2013 to July 2023 was reviewed, checking for innovations in diagnosis and treatment. Results: A total of 130 articles was included in the review. Conclusions: In addition to the therapeutic strategies already identified, such as classic surgery and pharmacological therapies, recent studies focus attention on the new frontiers of minimally invasive surgery, such as diagnostics using biomarkers and immunotherapy, which could represent a new therapeutic option and is possibly less risky than in the past, contributing in fact to the current knowledge of the scientific panorama in terms of “tumor microenvironment” and systemic implications deriving from oncological disease.

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Section: Postoperative Radiationmentioning

confidence: 99%

Wilms Tumor: Updates about Pathogenesis and New Possible Clinical Treatments of the Most Frequent Pediatric Urogenital Cancer: A Narrative Review

Perrotta,

Castellani

2023

Surgeries

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“…2,3 Outcome has improved over time with a long-term survival of 90% today. 4,5 The tumor occurs mainly in young children between 3 and 4 years. In more than 10% of children with WT a cancer predisposition syndrome (CPS) can be diagnosed 6,7 that may lead to an earlier diagnosis if regular abdominal ultrasounds are performed.…”

Section: Introductionmentioning

confidence: 99%

“…For more than 50 years this tumor has been treated in prospective multicenter and randomized trials by the International Society of Pediatric Oncology (SIOP), the Childrens' Oncology Group (COG), and others 2,3 . Outcome has improved over time with a long‐term survival of 90% today 4,5 . The tumor occurs mainly in young children between 3 and 4 years.…”

Section: Introductionmentioning

confidence: 99%

The impact of the route to diagnosis in nephroblastoma

Mergen,

Welter,

Furtwängler

et al. 2024

Cancer Medicine

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IntroductionWilms tumor (WT) is the most common childhood kidney cancer. It is a rapid growing embryonal tumor in young children and can be diagnosed with and without tumor related symptoms.MethodsWe retrospectively analyzed the route to diagnosis of WT treated prospectively according to the SIOP 93‐01/GPOH and 2001/GPOH in Germany between 1993 and 2022. Four routes were defined: diagnosis due to tumor‐related symptoms, incidental diagnosis during another disease, diagnosis by preventive examinations, and diagnosis within a surveillance program. For these groups we compared clinical and tumor characteristics and outcome.ResultsOf 2549 patients with WT 1822 (71.5%) were diagnosed by tumor‐related symptoms, 472 (18.5%) incidentally, 213 (8.4%) by preventive medical examinations, and 42 (1.6%) by surveillance. Age, general health status, tumor volume, and local and overall stage varied significantly between these groups. The youngest patients were those diagnosed by preventive medical examination (mean: 1.70 years). These patients also showed the best general health status. Tumor volume at diagnosis (549 mL) and after preoperative chemotherapy (255 mL) was significantly higher for children with tumor‐related symptoms. The highest percentage of local stage I (78.6%) and the lowest percentage of metastatic disease (4.8%) was found in the surveillance group. The outcome of patients was not significantly different, with up to 19.0% relapses in the surveillance group and 3.0% deaths in the group with tumor‐related symptoms.ConclusionThe route to diagnosis of WT correlates with age, general health status, tumor volume, and stage distribution, but does not impact the outcome of patients. Nonetheless, diagnosis without tumor related symptoms results in lower treatment burden and thus improved quality of life.

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Current surgical approaches to pediatric renal tumors

Glick,

Romao,

Pachl

et al. 2024

Pediatric Blood & Cancer

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Pediatric renal tumors are among the most common pediatric solid malignancies. Surgical resection is a key component in the multidisciplinary therapy for children with kidney tumors. Therefore, it is imperative that surgeons caring for children with renal tumors fully understand the current standards of care in order to provide appropriate surgical expertise within this multimodal framework. Fortunately, the last 60 years of international, multidisciplinary pediatric cancer cooperative group studies have enabled high rates of cure for these patients. This review will highlight the international surgical approaches to pediatric patients with kidney cancer to help surgeons understand the key differences and similarities between the European (International Society of Pediatric Oncology) and North American (Children's Oncology Group) recommendations.

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Children's Oncology Group's 2023 blueprint for research: Renal tumors

Cited by 7 publications

References 120 publications

Wilms Tumor: Updates about Pathogenesis and New Possible Clinical Treatments of the Most Frequent Pediatric Urogenital Cancer: A Narrative Review

Wilms Tumor: Updates about Pathogenesis and New Possible Clinical Treatments of the Most Frequent Pediatric Urogenital Cancer: A Narrative Review

The impact of the route to diagnosis in nephroblastoma

Current surgical approaches to pediatric renal tumors

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