Children with a History of Premature Adrenarche Have Good Health-Related Quality of Life at the Age of 12 Years

Liimatta, Jani; Sintonen, Harri; Utriainen, Pauliina; Voutilainen, Raimo; Jääskeläinen, Jarmo

doi:10.1159/000487134

Cited by 5 publications

(1 citation statement)

References 14 publications

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“…In addition to a physical examination and blood tests, HRQoL was assessed with a generic 16D © HRQoL instrument, which is based on the respective adult version (15D © ) but developed and validated for adolescents aged 12 to 15 years. Several studies have shown that the instrument is valid in the sense that it produces credible results and is capable of differentiating between healthy adolescents and patients in a wide range of health problems (14)(15)(16)(17)(18)(19). The 16D includes 16 dimensions (vitality, sight, breathing, distress, hearing, sleeping, eating, discomfort and symptoms, speech, physical appearance, school and hobbies, mobility, friends, mental function, excretion and depression) with five response options for each.…”

Section: Methodsmentioning

confidence: 99%

Health-related quality of life in boys with constitutional delay of growth and puberty

Kariola

Varimo²,

Huopio³

et al. 2022

Front. Endocrinol.

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IntroductionConstitutional delay of growth and puberty (CDGP) is the most common reason for delayed puberty in healthy male adolescents. The main indication for medical treatment for this condition is psychosocial burden. However, to the best of our knowledge, no previous study has addressed the impact of puberty-promoting treatment on health-related quality of life (HRQoL) among boys with CDGP.MethodsWe investigated HRQoL in 22 boys with CDGP, who participated in a randomized controlled trial in four Finnish pediatric endocrinology outpatient clinics between 2013 and 2017. The boys were randomized to receive either aromatase inhibitor letrozole (2.5mg/day; n=11) or intramuscular testosterone (1mg/kg/every 4 weeks; n=11) for 6 months and followed up to 12 months. HRQoL was assessed with a generic self-assessment 16D© instrument developed and validated for adolescents aged 12 to 15 years. The 16D includes 16 dimensions (vitality, sight, breathing, distress, hearing, sleeping, eating, discomfort and symptoms, speech, physical appearance, school and hobbies, mobility, friends, mental function, excretion and depression). The results were compared with an age-matched reference population that included 163 boys from the Finnish capital-city area. The study protocol is registered to ClinicalTrials.gov (registration number: NCT01797718).ResultsAt baseline, the mean 16D score of the CDGP boys was similar to the age-matched reference population (0.95 vs 0.96, p=0.838). However, the physical appearance score (satisfaction with general appearance, height and weight) was significantly lower in the CDGP boys (0.75 vs 0.92, p=0.004) than their peers. Twelve months after treatment, Appearance had improved significantly (0.75 vs 0.87, p=0.004) and no HRQoL dimension was inferior compared to the age-matched reference population.DiscussionIn terms of HRQoL, the main impact of delayed puberty was dissatisfaction with physical appearance. Puberty promoting therapy was associated with a positive change in perceived appearance, with no clear difference between low-dose testosterone and letrozole treatments.

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Section: Methodsmentioning

confidence: 99%

Health-related quality of life in boys with constitutional delay of growth and puberty

Kariola

Varimo²,

Huopio³

et al. 2022

Front. Endocrinol.

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Cognitive performance in young adult women with a history of premature adrenarche

Tennilä,

Muukkonen,

Utriainen

et al. 2024

Pediatr Res

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Background Girls with premature adrenarche (PA) mature earlier than peers and have been found to have greater symptom accounts reflecting anxiety compared to peers. It is not known, however, whether PA effects cognitive development. This longitudinal case-control cohort study aimed: (1) To investigate whether a history of PA leads to measurable changes in adulthood cognitive performance, and (2) to assess whether findings characteristic of PA girls predict adulthood cognitive performance. Methods Twenty-seven girls with PA and 27 age-matched control girls were examined and followed from mid-childhood (mean age 7.2 years) until early adult age (18.5 years). Wechsler Adult Intelligence Scale, Fourth Edition scores were used as main outcome measure. Results Allostatic load (AL) scores, which compile multisystem variables to reflect the overall wear and tear of the body from increased and prolonged stress, were higher in the PA group in both prepuberty and adulthood, but there were no differences in WAIS-IV results between the groups (full-scale IQ 92.7 vs. 97.5, p 0.376; no differences in separate indexes). Childhood androgen levels, glucose metabolism biomarkers, and AL scores failed to predict adulthood cognitive performance outcomes. Conclusion The study suggests that PA does not predispose to adverse adulthood outcomes of cognitive development. Impact The study suggests that a history of premature adrenarche (PA) does not affect cognitive performance in adult age. Childhood androgen levels and biomarkers of glucose metabolism failed to predict adulthood cognitive outcomes in this study. Allostatic load scores were elevated in the PA group both in childhood and adulthood but did not predict adulthood cognitive outcomes.

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Health-Related Quality of Life of Young Adult Women with a History of Premature Adrenarche

Tennilä,

Sintonen,

Utriainen

et al. 2024

Horm Res Paediatr

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Introduction: Children with premature adrenarche (PA) have increased adrenal androgen concentrations and earlier pubertal development than their peers. Early sexual maturation and exposure to androgens have both been associated with an increased risk for neuropsychological adversities in adulthood. Such adversities would presumably influence the experienced health-related quality of life (HRQoL) of those affected. Methods: In a longitudinal case-control cohort study, 30 PA girls and 40 age-matched controls were followed from childhood to young adult age. The main outcome measure was the total 15D HRQoL score. In addition, we assessed specific dimensions of the questionnaire, the subjects’ relationship statuses, and living arrangements. Results: There were no differences between the groups in the overall 15D scores (PA, 0.956 [0.052]; control, 0.947 [0.055]; p 0.482) or on any dimension of this instrument. Conclusion: The study suggests that a history of PA does not lead to impaired HRQoL in adult age.

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Children with a History of Premature Adrenarche Have Good Health-Related Quality of Life at the Age of 12 Years

Cited by 5 publications

References 14 publications

Health-related quality of life in boys with constitutional delay of growth and puberty

Health-related quality of life in boys with constitutional delay of growth and puberty

Cognitive performance in young adult women with a history of premature adrenarche

Health-Related Quality of Life of Young Adult Women with a History of Premature Adrenarche

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