Children with juvenile idiopathic arthritis frequently experience interruptions to their medical therapy

Kazamia, Kalliopi; Holmquist, Lars Erik; Fagerlund, Anders; Berntson, Lillemor

doi:10.1111/apa.12556

Cited by 3 publications

(1 citation statement)

References 26 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…TNF-alpha inhibitors are used in approximately 20-25% of children with JIA in Sweden [29]. A review concluded that some children with JIA develop TMJ arthritis despite TNF-alpha inhibitors [4].…”

Section: Discussionmentioning

confidence: 99%

Temporomandibular condylar alterations in juvenile idiopathic arthritis most common in longitudinally severe disease despite medical treatment

et al. 2014

Self Cite

View full text Add to dashboard Cite

BackgroundJuvenile idiopathic arthritis (JIA) is an autoimmune, heterogeneous disease and the temporomandibular joint (TMJ) can be affected, with consequences for mandibular growth and function. The aim of this study was to evaluate the importance of longitudinal medical treatment and the burden of disease activity on the development of temporomandibular condylar alterations as judged on panoramic radiographs.MethodsThe study was a retrospective evaluation of dental and medical records in consecutive JIA patients referred to three specialist dental clinics in Sweden during an eight-year period. Data on the total pharmacological treatment and disease activity were evaluated longitudinally from disease onset to the time of the panoramic examination, during a median observation period of 2.5 years. The radiographs were analysed in terms of structural and shape alterations in the condyles and judged dichotomously.ResultsPanoramic examinations were analysed in 158 patients from 266 referrals diagnosed with JIA. Condylar alterations (shape or structural) were seen in 68 patients (43%). Patients with condylar alterations were more extensively treated over time compared with those without condylar alterations. Powerful disease activity and/or potent medication at any time during the course of the disease implied an increased risk of alterations.ConclusionsPatients with JIA who require more intensive medication over time run the greatest risk of condylar alterations. As yet, current medical programmes have not been specified for the TMJ and more knowledge in this area is needed.

show abstract

Section: Discussionmentioning

confidence: 99%

Temporomandibular condylar alterations in juvenile idiopathic arthritis most common in longitudinally severe disease despite medical treatment

et al. 2014

Self Cite

View full text Add to dashboard Cite

show abstract

Methotrexate Intolerance in Juvenile Idiopathic Arthritis: Definition, Risks, and Management

Wibrand,

Kyvsgaard,

Herlin

et al. 2024

Pediatr Drugs

View full text Add to dashboard Cite

Juvenile idiopathic arthritis is the most common rheumatic disorder in childhood and adolescence posing a significant threat of short-term and long-term disability if left untreated. Methotrexate is a folic acid analog with various immunomodulatory properties. It has demonstrated significant efficacy for the treatment of juvenile idiopathic arthritis, often considered the preferred first-line disease-modifying anti-rheumatic drug given as monotherapy or in combination with biological drugs. Despite this, there is a considerable risk for treatment disruptions owing to the high prevalence of methotrexate intolerance, with symptoms such as nausea, stomach ache, vomiting, and behavioral symptoms. Many different risk factors for the intolerance have been proposed including gender, age, disease activity, treatment duration, dosing and administration, and genetic and psychological factors. As the studies have shown contradictory results, many questions are left unanswered. Therefore, a consensus regarding outcome measures and reporting is crucial. In this review, we describe the identification and assessment of methotrexate intolerance and evaluate potential risk factors, genetic associations as well as management strategies.

show abstract

Etanercept

2015

Reactions Weekly

View full text Add to dashboard Cite

Children with juvenile idiopathic arthritis frequently experience interruptions to their medical therapy

Abstract: Our study shows a high percentage of interrupted medical therapies, due to adverse events or inefficacy, in children with JIA. Adverse events from methotrexate and biological agents were seldom severe. The results highlight the need for better predictive factors to guide therapy.

Cited by 3 publications

References 26 publications

Temporomandibular condylar alterations in juvenile idiopathic arthritis most common in longitudinally severe disease despite medical treatment

Temporomandibular condylar alterations in juvenile idiopathic arthritis most common in longitudinally severe disease despite medical treatment

Methotrexate Intolerance in Juvenile Idiopathic Arthritis: Definition, Risks, and Management

Etanercept

Contact Info

Product

Resources

About