198/200; Main text 4099/4000. Refs 85; Tables 1; Figures 1; Appendices 7. 2 CHESS PROMs review Cephalgia FTC:110117 Re-submit 240517 Tables edited 270717 Structured Abstract: (198/200) Aims To critically appraise, compare and synthesise the quality and acceptability of multi-item PROMs for adults with chronic or episodic headache. Methods Systematic literature searches of major databases (1980-2016) to identify published evidence of PROM measurement and practical properties. Data on study quality (COSMIN), measurement and practical properties per measure was extracted and assessed against accepted standards to inform an evidence synthesis. Results From 10,903 reviewed abstracts, 103 articles were assessed in full; 46 provided evidence for 23 PROMs: eleven specific to the health-related impact of migraine (n=5) or headache (n=6); six assessed migraine-specific treatment response/satisfaction; six were generic measures. Evidence for measurement validity and score interpretation was strongest for two measures of impact-Migraine-Specific Quality of Life Questionnaire (MSQ v2.1) and Headache Impact Test 6-item (HIT-6), and one of treatment response-the Patient Perception of Migraine Questionnaire (PPMQ-R). Evidence of reliability was limited, but acceptable for the HIT-6. Responsiveness was rarely evaluated. Evidence for the remaining measures was limited. Patient involvement was limited and poorly reported. Conclusion Whilst evidence is limited, three measures have acceptable evidence of reliability and validity-HIT-6, MSQ v2.1 and PPMQ-R. Only the HIT-6 has acceptable evidence supporting its completion by all 'headache' populations.