Children with motor impairment related to cerebral palsy: Prevalence, severity and concurrent impairments in China

He, Ping; Chen, Gong; Wang, Zhenjie; Guo, Chao; Zheng, Xiaoying

doi:10.1111/jpc.13444

Cited by 22 publications

(15 citation statements)

References 25 publications

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“…The present results yielded a peak CP prevalence of 2.8 per 1000 children, which is similar to those reported in a previous meta-analysis for a specific age range [ 3 ] but higher than those of other surveys in the Chinese population. The prevalence of CP in China and Hong Kong was reported to be from 1.3 to 1.6 per 1000 children [ 13 – 15 ], which is lower than that in other developed countries. However, our present findings based on the entire population of Taiwan provide new evidence that Chinese children do not have a lower CP risk.…”

Section: Discussionmentioning

confidence: 99%

“…Studies conducted in the United States have reported that Asian children had a lower CP prevalence than Caucasian [ 11 , 12 ]. Furthermore, surveys in China and Hong Kong have reported that the prevalence of CP was 1.3 to 1.6 per 1000 children, which is lower than that in Western countries [ 13 – 15 ]. However, it is unclear whether the lower prevalence of CP in Asian children can be attributed due to ethnic disparities.…”

Section: Introductionmentioning

confidence: 99%

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Association between socioeconomic status and cerebral palsy

Tseng

Lee²,

Chou³

et al. 2018

PLoS ONE

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BackgroundThe present study investigated the annual prevalence of cerebral palsy (CP) among children aged <7 years in Taiwan and the association between socioeconomic status and CP prevalence.MethodsData from the Taiwan National Health Insurance Research Database for the 2002−2008 period were used in this population-based study. Severe and total CP were defined according to catastrophic illness certificate and medical claim records, respectively. The annual CP prevalence was calculated as the number of children with CP among all children aged <7 years.ResultsFrom 2002 to 2008, the annual prevalence of total and severe CP ranged from 1.9 to 2.8 and from 1.1 to 1.4 per 1000 children, respectively. Boys were 30% more likely to have CP than girls [adjusted relative risk (RR) and 95% confidence interval (CI) ranged from 1.3 (1.2−1.4) to 1.4 (1.2−1.5)]. Low family income was associated with a higher CP prevalence [adjusted RR (95% CI) ranged from 5.1 (4.2−6.2) to 6.4 (5.4−7.6)]. The prevalence of CP in rural area was higher than that in urban or suburban areas. The mortality rate of severe CP ranged from 12.2−22.7 per 1000 children within the 7 years study period.ConclusionsThe prevalence of CP in Taiwan is similar to that in Western countries. A higher prevalence of CP is associated with male sex, low income, and rural residential location. Our findings provide insights into CP epidemiology among the Chinese population.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Association between socioeconomic status and cerebral palsy

Tseng

Lee²,

Chou³

et al. 2018

PLoS ONE

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“…All these tests were negative. Additionally, the parameters of hUCB-MSC vitality, and biological characteristics were tested to meet with International Society for Cellular Therapy standards 19 and documented in test reports for each batch of cell product, including morphology, cell count (5× 10 7 cell/mL, range 90% to 120%, and 1 mL/vial), viability rate (≥90%), cell surface markers, colony-forming ability, differential capacity, and so on. Regarding the cell surface markers, it was found that CD90, CD73, CD105, and CD29 were higher than 95%, and CD45, CD34, CD79a/ CD19, CD14, and HLA-DR were less than 2%.…”

Section: Methodsmentioning

confidence: 99%

“…For mild, moderate, severe, and extremely severe groups of motor impairment, weighted proportions of CP are 14.12%, 20.35%, 27.44%, and 38.09%, respectively. Weighted proportions of concurrent visual, hearing, and cognitive impairment are 5.00%, 6.98%, and 71.06%, respectively 7 .…”

Section: Introductionmentioning

confidence: 99%

A Randomized, Placebo-Controlled Trial of Human Umbilical Cord Blood Mesenchymal Stem Cell Infusion for Children With Cerebral Palsy

et al. 2018

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Cerebral palsy (CP) is a common disability which results in permanent chronic motor disability appearing in early childhood. Recently human umbilical cord blood mesenchymal stem cell (hUCB-MSC) infusion has emerged as a promising therapeutic strategy for CP, and the treatment efficacy remains to be confirmed by clinical trials. All 54 patients received basic rehabilitation as a background treatment. The infusion group comprising 27 patients received 4 infusions of hUCB-MSCs (intravenous infusions at a fixed dose of 5 × 107) and basic rehabilitation treatment, whereas 27 patients in the control group received 0.9% normal saline and basic rehabilitation treatment. Several indices were tested from baseline up to 24 months posttreatment regarding efficacy and safety evaluations, including the gross motor function measurement 88 (GMFM-88) scores, the comprehensive function assessment (CFA), lab tests, electroencephalogram (EEG), routine magnetic resonance imaging (MRI), and adverse events. The changes in the total proportion of GMFM-88 and total scores of CFA in the hUCB-MSC infusion group were significantly higher than that in control group at 3, 6, 12, 24 months posttreatment. Less diffuse slow waves were noticed after hUCB-MSC infusion in patients with slowing of EEG background rhythms at baseline. Based on the routine MRI exams, improvements in cerebral structures were rare after treatment. Serious adverse events were not observed during the whole study period. The results of the study indicated that hUCB-MSC infusion with basic rehabilitation was safe and effective in improving gross motor and comprehensive functions in children with CP.

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“…However, both the sensory and motor functions of these persons should be evaluated to gain better understanding of CP. It has been reported that visual and hearing impairments are associated with severity of motor function (Beckung et al, 2008;He, Chen, Wang, Guo, & Zheng, 2017).…”

Section: Introductionmentioning

confidence: 99%

Olfactory Function in Persons with Cerebral Palsy

Nakashima

Katayama²,

Sugiura

et al. 2019

Policy Practice Intel Disabi

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Although visual and hearing impairments associated with cerebral palsy (CP) have been reported, there is a lack of studies on olfactory function in persons with CP. We evaluated olfactory function related to meal enjoyment in persons with CP with severe motor and intellectual disabilities (ID). Subjects included 14 persons with gross motor function classification system (GMFCS) level III, IV, or V and 14 age‐ and gender‐matched controls (7 women and 7 men per group). The mean ages (± standard deviation) were 54.6 ± 9.9 years and 55.6 ± 9.5 years, in persons with CP and controls, respectively. Olfactory function was assessed with the Odor Stick Identification Test for the Japanese (OSIT‐J), which includes 12 different odorants that are familiar to the Japanese population. Smell identification evaluated by the percentage of correct answers was significantly lower in the CP group (34.4 ± 24.1%) than in the control group (63.1 ± 16.9%). Smell identification was more impaired than smell detection (odor recognition without identification). No relationship was found between olfactory function and the GMFCS level. Future studies should investigate potential differences in olfactory function between children with and without CP, and between those with mild and severe CP. Olfactory function was significantly worse in adults with CP than in controls. Attention should be given to the olfactory function in persons with CP.

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Children with motor impairment related to cerebral palsy: Prevalence, severity and concurrent impairments in China

Abstract: Gender, multiple births and family adults with CP were significantly associated with CP-related motor impairment in Chinese children. Proportions of CP and concurrent impairments that increased with severity of motor impairment were observed.

Cited by 22 publications

References 25 publications

Association between socioeconomic status and cerebral palsy

Association between socioeconomic status and cerebral palsy

A Randomized, Placebo-Controlled Trial of Human Umbilical Cord Blood Mesenchymal Stem Cell Infusion for Children With Cerebral Palsy

Olfactory Function in Persons with Cerebral Palsy

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