Children with myelomeningocele have shorter stature, greater body weight, and lower bone mineral content than healthy children

Polito, Cesare; Gaizo, D. Del; Manso, Gaetano Di; Stabile, D.; Gado, Roberto Del

doi:10.1016/0271-5317(95)02031-8

Cited by 2 publications

(7 citation statements)

References 9 publications

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“…Of these, 11 articles met the inclusion criteria [13][14][15][16][17][29][30][31][32][33][34]. Although not yielded by the search criteria, five additional articles on this topic were identified and included [35][36][37][38][39]. Thus, 16 articles about BMD and SB were analysed in detail.…”

Section: Resultsmentioning

confidence: 99%

“…In the study by Van Speybroeck et al [62], the results are presented as medians (interquartile ranges) compared with healthy controls, and reference values are unknown according to age group and sex. However, in an observational controlled study with 32 children with MMC and 30 healthy children, above-normal values were found for PTH in two patients and for AP in eight patients with MMC, but reference intervals were not provided [37]. If these apparent antagonisms are confirmed, it is worth considering the possibility of several subgroups of patients.…”

Section: Metabolic Bone Markersmentioning

confidence: 95%

“…Bone densitometry has been the technique of choice for the evaluation of BMD in studies involving patients with MMC. However, the available studies have used either single-energy beam absorptiometry [13,36,37] or dual-energy beam absorptiometry (DXA) [14,29,31,33,35] as well as different types of apparatuses, making it difficult to compare the results.…”

Section: Bmd Assessmentmentioning

confidence: 99%

“…Dietary and metabolic factors include the intake of vitamin-D-rich foods and the association between obesity and 25-OHD levels, respectively [62,79,80]. To our knowledge, only three studies have applied a food frequency questionnaire to determine calcium intake [14,17,37] Theoretically, the absorption of fat-soluble vitamins, including vitamin D, may be impaired after ileocystoplasty. However, in the study by Taskinen et al [38], approximately 42% of patients had moderate to severe vitamin D deficiency.…”

Section: Calcium and Vitamin D Deficienciesenvironmental And Dietary mentioning

confidence: 99%

“…In contrast, at 12 months, infants born with MMC exhibited shorter leg lengths and smaller shank circumferences than those with TD [85]. Studies have documented that children with MMC have a short stature [17,30,33,37,53,54,[86][87][88], particularly those with high lesion neurological levels [87,89], with significantly lower values for height in immobilized than in mobilized patients [17,33] compared with the values for controls [17,62,90], and they tended to weigh less than other children of the same age [54,59,86]. However, the comparison of weight with height suggested that children with MMC were relatively obese [54,86].…”

Section: Other Factors From An Anthropometricmentioning

confidence: 99%

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Update on bone fragility in spina bifida

Marreiros¹

2018

PRM

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BACKGROUND CONTEXT: Patients with spina bifida (SB) are at risk for pathological fractures and low bone mineral density (BMD). PURPOSE AND METHODS: This article reviews the literature and provides a comprehensive overview of how the characteristics of SB and its associated comorbidities intersect with bone fragility to identify possible pathophysiological mechanisms of fractures and low BMD. RESULTS: Bone fragility occurs early in the life of patients with SB as a result of a disturbance that determines changes in bone shape, quantity, and quality, as poor mineralization reduces bone stiffness. Bone fragility in SB occurs due to local and systemic factors and may be considered a state of impaired bone quality of multifactorial aetiology, with complex interacting influences of neurological, metabolic, and endocrinological origins and the presence of smaller bones. Bone fragility should be evaluated globally according to skeletal age and Tanner staging. The phases of the evolution of Charcot joints seem to intercept the evolution of epiphyseal fractures. Charcot arthropathy in SB may be initiated by the occurrence of repetitive trauma and fractures in epiphyseal and subepiphyseal regions, where there is a deficit of bone mineralization and greater bone mass deficits. CONCLUSION: Bone fragility in MMC potentially has a multifactorial neuro-endocrinological-metabolic-renal dimension, with smaller bones, lower bone mass, and mineralization deficits affecting bone strength.

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