Children with Respiratory Disease Associated with Metapneumovirus in Hong Kong

Peiris, J. S. Malik; Tang, Wing Hong; Chan, Kwok Hung; Khong, Pek Lan; Guan, Yi; Lau, Yu Lung; Chiu, Susan S.

doi:10.3201/eid0906.030009

Cited by 369 publications

(408 citation statements)

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“…3/1000 inhabitants for infants aged <12 months and children aged 12-23 months, respectively) [25] but was lower than that observed in studies performed in Hong Kong (4 . 4/ 1000 inhabitants aged <6 years) [6] and South Africa (5 . 7/1000 human immunodeficiency virus uninfected children) [7].…”

Section: Discussionmentioning

confidence: 99%

“…Accumulating evidence has shown that HMPV has a worldwide distribution and seasonal circulation, that it is a common respiratory pathogen in childhood, and that it contributes substantially to the aetiology and pathogenesis of lower respiratory tract infection (LRTI) [2][3][4][5][6][7]. Numerous studies have focused on the clinical and epidemiological characteristics of HMPV infection, but few have been population based, and consequently the available information on the incidence and burden of this disease remains scarce.…”

Section: Introductionmentioning

confidence: 99%

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Hospitalization rates for human metapneumovirus infection among 0- to 3-year-olds in Gipuzkoa (Basque Country), Spain

et al. 2008

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SUMMARYNumerous studies have been published on human metapneumovirus (HMPV) infection, but few have been population based. The main aim of this study was to estimate the incidence rate of hospitalization for community-acquired HMPV infection in infants and children aged <3 years. Between July 2004 and June 2007, 796 episodes (742 patients) of community-acquired acute respiratory infection were hospitalized. HMPV was detected in 90 episodes (11 . 3%). Fifty-nine episodes occurred in infants aged <1 year. The mean length of hospital stay was 6 . 2 days (range 2-31 days). Thirteen children required admission to the intensive care unit. Viral co-infections were detected in 46 episodes (51 . 1%). The incidence rate of hospitalization per 1000 inhabitants was 2 . 6 (95 % CI 2 . 1-3 . 2), lower than that for respiratory syncytial virus, but higher than that observed for the influenza and parainfluenza viruses. HMPV is a major respiratory pathogen that leads to a high hospitalization rate.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Hospitalization rates for human metapneumovirus infection among 0- to 3-year-olds in Gipuzkoa (Basque Country), Spain

et al. 2008

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“…Swab samples were subsequently tested using quantitative reverse-transcription PCR to detect influenza A virus and quantify virus shedding. Total nucleic acid was extracted using the NucliSens easy MAG extraction system (bioMerieux; Boxtel), according to the manufacturer's instructions, and 12 μL of extracted nucleic acid with a random primer was used to prepare complementary DNA with an Invitrogen Superscript III kit (Invitrogen), as described elsewhere [16]. Influenza A virus was detected with a PCR assay, as described elsewhere [17].…”

Section: Laboratory Methodsmentioning

confidence: 99%

Influenza A Virus Shedding and Infectivity in Households

Tsang¹,

Cowling²,

Fang³

et al. 2015

J Infect Dis.

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109

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Background. Viral shedding is often considered to correlate with the infectivity of influenza, but the evidence for this is limited.Methods. In a detailed study of influenza virus transmission within households in 2008-2012, index case patients with confirmed influenza were identified in outpatient clinics, and we collected nose and throat swab specimens for testing by reverse-transcription polymerase chain reaction from all household members regardless of illness. We used individual-based hazard models to characterize the relationship between viral load (V ) and infectivity.Results. Assuming that infectivity was proportional to viral load V gave the worst fit, because it strongly overestimated the proportion of transmission occurring at symptom onset. Alternative models assuming that infectivity was proportional to a various functions of V provided better fits, although they all overestimated the proportion of transmission occurring >3 days after symptom onset. The best fitting model assumed that infectivity was proportion to V γ , with estimates of γ = 0.136 and γ = 0.156 for seasonal influenza A(H1N1) and A(H3N2) respectively.Conclusions. All the models we considered that used viral loads to approximate infectivity of a case imperfectly explained the timing of influenza secondary infections in households. Identification of more accurate correlates of infectivity will be important to inform control policies and disease modeling.

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“…breathing difficulties, peaked at day five, whereas airway obstruction and hyperresponsiveness lasted until day 70. These latter observations along with earlier observation that HMPV may be associated to a subsequent history of asthma [13,24] in children make the mouse model an excellent tool for the study of the earlier steps of asthma history.…”

Section: Mouse Model (Balb/c)mentioning

confidence: 74%

Animal models for human Metapneumovirus (HMPV) infections

2007

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-Since its detection in 2001 the human Metapneumovirus (HMPV), a member of the Paramyxoviridae family, was observed to be a serious pathogen in human respiratory infections during childhood. Meanwhile, several animal models have been established to study the virus-host interactions and pathogenic effects. Mainly, small laboratory animals like mice and cotton rats have been used, although the usage of these two species for HMPV research is controversially discussed and contradictious results were obtained by different groups. Further trials with ferrets, hamsters and non human primates were performed revealing different success in their individual usage. In this review we present the different animal models, summarize their advantages and disadvantages, and discuss the controversial results from different studies.

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Children with Respiratory Disease Associated with Metapneumovirus in Hong Kong

Cited by 369 publications

References 20 publications

Hospitalization rates for human metapneumovirus infection among 0- to 3-year-olds in Gipuzkoa (Basque Country), Spain

Hospitalization rates for human metapneumovirus infection among 0- to 3-year-olds in Gipuzkoa (Basque Country), Spain

Influenza A Virus Shedding and Infectivity in Households

Animal models for human Metapneumovirus (HMPV) infections

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