Children with Type 1 Diabetes

Alhaddad, Fatima; Musaiger, Abdulrahman O.; Al-Qallaf, Mahmood

doi:10.12816/0014394

Cited by 2 publications

(1 citation statement)

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“…This research is a substudy of a larger study undertaken by the author to explore dietary and health risk factors of T1DM in children. 13 , 14 The objective of the larger study was to evaluate the association between physiological factors, such as vitamin D levels and lifestyle factors (eg, activity levels and frequency of sunlight exposure) and diabetes prevalence in a small, but representative sample of newly diagnosed children. In this regard, the ideal assay method for determining serum vitamin D levels in this sample of children was subject to considerable debate; hence, this study reports on the experience of assaying vitamin D levels using two different methods to help inform future practice.…”

Section: Introductionmentioning

confidence: 99%

Assessment of vitamin D levels in newly diagnosed children with type 1 diabetes mellitus comparing two methods of measurement: a facility's experience in the Middle Eastern country of Bahrain

Al-Haddad¹,

Rajab²,

Al-Qallaf³

et al. 2016

DMSO

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BackgroundThe number of children being diagnosed with type 1 diabetes mellitus (T1DM) is on the rise and has more than doubled in the past 10 years in Bahrain. Some studies have linked low vitamin D levels with an increased risk of diabetes. There are concerns regarding the variations in circulating 25(OH)D levels measured by different laboratories and by using different analytical techniques.ObjectiveThe aim of this study was to evaluate the vitamin D levels of newly diagnosed children with T1DM using the “gold standard method” with high-pressure liquid chromatography–tandem mass spectrometry methods compared to the chemiluminescence micro-particle immunoassay (CMIA) used in a hospital laboratory.SubjectsEighteen children, aged 6–12 years, who received a confirmed diagnosis of T1DM in 2014 were chosen as subjects.MethodsSerum vitamin D levels were assessed in a hospital, while an extra aliquot of blood collected during routine blood collection after acquiring informed written consents from the subjects, and sent to Princess Al-Jawhara Center for Molecular Medicine and Inherited Disorders to be analyzed by ultra-performance liquid chromatography–tandem mass spectrometry (UPLC-MS/MS).ResultsThe mean age of the study group was 9±2 years. The mean total of 25(OH)D levels (D3 and D2) assessed by UPLC-MS/MS was 49.7±18.8, whereas the mean total of 25(OH)D levels obtained from the CMIA assay was 44.60±13.20. The difference in classification between the two methods was found to be statistically significant (P=0.004). A Bland–Altman plot showed a poor level of agreement between the two assay methods. The CMIA overestimated insufficient values and underestimated deficiency, when compared to UPLC-MS/MS.ConclusionThere was a statistically significant difference between the two assay methods with CMIA overestimating vitamin D insufficiency. Clinicians should be prudent in their assessment of a single vitamin D reading, when the gold standard method is not available or feasible.

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Section: Introductionmentioning

confidence: 99%

Assessment of vitamin D levels in newly diagnosed children with type 1 diabetes mellitus comparing two methods of measurement: a facility's experience in the Middle Eastern country of Bahrain

Al-Haddad¹,

Rajab²,

Al-Qallaf³

et al. 2016

DMSO

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Intergenerational Transmission of Poverty in Sub-Saharan Africa - A Select Annotated Bibliography with Special Reference to Irreversibilities Associated with Poor Nutrition, Health and Education

Jones

Moore

2006

SSRN Journal

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Children with Type 1 Diabetes

Cited by 2 publications

References 134 publications

Assessment of vitamin D levels in newly diagnosed children with type 1 diabetes mellitus comparing two methods of measurement: a facility's experience in the Middle Eastern country of Bahrain

Assessment of vitamin D levels in newly diagnosed children with type 1 diabetes mellitus comparing two methods of measurement: a facility's experience in the Middle Eastern country of Bahrain

Intergenerational Transmission of Poverty in Sub-Saharan Africa - A Select Annotated Bibliography with Special Reference to Irreversibilities Associated with Poor Nutrition, Health and Education

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Children with Type 1 Diabetes

Cited by 2 publications

References 134 publications

Assessment of vitamin D levels in newly diagnosed children with type 1 diabetes mellitus comparing two methods of measurement: a facility&#39;s experience in the Middle Eastern country of Bahrain

Assessment of vitamin D levels in newly diagnosed children with type 1 diabetes mellitus comparing two methods of measurement: a facility&#39;s experience in the Middle Eastern country of Bahrain

Intergenerational Transmission of Poverty in Sub-Saharan Africa - A Select Annotated Bibliography with Special Reference to Irreversibilities Associated with Poor Nutrition, Health and Education

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Assessment of vitamin D levels in newly diagnosed children with type 1 diabetes mellitus comparing two methods of measurement: a facility's experience in the Middle Eastern country of Bahrain

Assessment of vitamin D levels in newly diagnosed children with type 1 diabetes mellitus comparing two methods of measurement: a facility's experience in the Middle Eastern country of Bahrain