The learning outcomes for the Physics Subject in Bandar Lampung City are low. In addition, the Physics Subject is also not popular among students, especially at the high school level in Bandar Lampung City. To overcome these problems, teachers need to do innovative learning. This study aimed to produce an inquiry-based Physics E-LKPD, which experts validated, and to analyze the effect of the product on learning interest and learning outcomes for Physics in SMA in Bandar Lampung City. Research is a development study with a research population of 17 High Schools in Bandar Lampung City. The school sample was taken using a stratified random sampling technique, while the student samples were taken using a proportional stratified method. Product data was collected through interviews, observation, questionnaires, and validation of material, design, and media experts. In contrast, data on learning outcomes and interest in learning the field of physics studies were taken from documentation and questionnaires. The effect of using guided inquiry-based E-LKPD was analyzed by t-test. The study results illustrate that the development of guided inquiry-based E-LKPD has met the valid and practical criteria for learning physics in high school, especially the solar system. The E-LKPD was developed through defining, designing, and developing. Based on these results, it can be concluded that guided inquiry-based E-LKPD positively impacts learning outcomes and student learning interests.