Chili, but Not Turmeric, Inhibits Iron Absorption in Young Women from an Iron-Fortified Composite Meal

Tuntipopipat, Siriporn; Judprasong, Kunchit; Zeder, Christophe; Wasantwisut, Emorn; Winichagoon, Pattanee; Charoenkiatkul, Somsri; Hurrell, Richard F.; Walczyk, Thomas

doi:10.1093/jn/136.12.2970

Cited by 62 publications

(45 citation statements)

References 33 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…They all received the same iron isotope-labeled reference meal. Sixtyseven participated in studies of iron-fortified fish sauce 29 and the effect of spices on iron absorption, 30 and 25 were healthy controls in a study of the effects of hemoglobinopathies on iron absorption (M Zimmermann, unpublished data). The first two studies have been reported previously.…”

Section: Methodsmentioning

confidence: 99%

See 1 more Smart Citation

Adiposity in women and children from transition countries predicts decreased iron absorption, iron deficiency and a reduced response to iron fortification

et al. 2008

View full text Add to dashboard Cite

Background: Overweight is increasing in transition countries, while iron deficiency remains common. In industrialized countries, greater adiposity increases risk of iron deficiency. Higher hepcidin levels in obesity may reduce dietary iron absorption. Therefore, we investigated the association between body mass index (BMI) and iron absorption, iron status and the response to iron fortification in populations from three transition countries (Thailand, Morocco and India). Methods: In Thai women (n ¼ 92), we examined the relationship between BMI and iron absorption from a reference meal containing B4 mg of isotopically labeled fortification iron. We analyzed data from baseline (n ¼ 1688) and intervention (n ¼ 727) studies in children in Morocco and India to look for associations between BMI Z-scores and baseline hemoglobin, serum ferritin and transferrin receptor, whole blood zinc protoporphyrin and body iron stores, and changes in these measures after provision of iron. Results: In the Thai women, 20% were iron deficient and 22% were overweight. Independent of iron status, a higher BMI Z-score was associated with decreased iron absorption (P ¼ 0.030). In the Indian and Moroccan children, 42% were iron deficient and 6.3% were overweight. A higher BMI Z-score predicted poorer iron status at baseline (Po0.001) and less improvement in iron status during the interventions (Po0.001). Conclusions: Adiposity in young women predicts lower iron absorption, and pediatric adiposity predicts iron deficiency and a reduced response to iron fortification. These data suggest the current surge in overweight in transition countries may impair efforts to control iron deficiency in these target groups. Interactions of the 'double burden' of malnutrition during the nutrition transition may have adverse consequences.

show abstract

Section: Methodsmentioning

confidence: 99%

“…The first two studies have been reported previously. 29,30 Exclusion criteria included pregnancy, lactation, gastrointestinal disorders or metabolic diseases. The absence of thalassemia was verified by hemoglobin typing using a commercial HPLC-based autoanalyzer (Variant, Bio-Rad, Hercules, CA, USA).…”

Section: Methodsmentioning

confidence: 99%

Adiposity in women and children from transition countries predicts decreased iron absorption, iron deficiency and a reduced response to iron fortification

et al. 2008

View full text Add to dashboard Cite

show abstract

“…74 Chilli powder (Capsicum annuum) has been found to lower iron absorption in the GIT in humans 75 and the polyphenolic compounds in the spice (capsaicin) presumably causes this by forming complexes with iron within the gut. 76 The high mineral content of dandelion (Taraxacum officinale) is believed to result in the formation of complexes between drugs, resulting in a decreased absorption.…”

Section: Interactions Affecting Drug Absorptionmentioning

confidence: 99%

The safe usage of herbal medicines: counterindications, cross-reactivity and toxicity

Cock¹

2014

Phcog Commn.

View full text Add to dashboard Cite

Background: Plants have been used therapeutically for thousands of years and continue to be the main treatment modality for a large percentage of the world's population. Furthermore, herbal medicine usage is increasing in Western countries as complementary (and sometimes alternative) treatments in conjunction with allopathic medicine. At the same time, the usage of allopathic medicines is being increasingly incorporated into the medicinal systems of developing countries, often resulting in the concurrent usage of both systems. Importance of the Study: Despite the widespread usage in developing countries and the trend of increasing medicinal plant usage in Western countries, herbal medicines remain understudied and there are misunderstandings amongst users and practitioners about the safe usage of these medications, particularly when used in conjunction with other medicines. Herbal medicines are generally not held to the same rigorous standards as allopathic medicines. There is usually a lack of industry regulation and manufacturing standards and guidelines, resulting in inferior (or unsafe) medicines being sold to consumers. Similarly, there is a lack of understanding amongst many medical practitioners of both traditional and allopathic medicine systems of how drugs from the two systems can be safely used together. Aim: The aim of this review is to summarise the current knowledge about herbal medicines and how they can be used safely, with the aim of not only highlighting some of the unsafe uses, but also to stimulate further research. I have also aimed to highlight the need for greater regulation and standardisation of herbal medicines.

show abstract

“…Awareness should also be made with the concurrent intake of certain fortified foods. Tuntipopipat et al (2006) reported a reduction in the absorption of iron by a group of healthy females that consumed iron-fortified foods together with Chilli pepper. The iron was bound to capsaicin, the polyphenos that are found in Chilli (Capsicum annum).…”

Section: Possible Therapeutic Failure or Development Of Drug Resistancementioning

confidence: 99%

Interaction of Traditional Remedies Against HIV, Nutrients and ARVs

Barros¹

2011

Recent Translational Research in HIV/AIDS

View full text Add to dashboard Cite

Chili, but Not Turmeric, Inhibits Iron Absorption in Young Women from an Iron-Fortified Composite Meal

Cited by 62 publications

References 33 publications

Adiposity in women and children from transition countries predicts decreased iron absorption, iron deficiency and a reduced response to iron fortification

Adiposity in women and children from transition countries predicts decreased iron absorption, iron deficiency and a reduced response to iron fortification

The safe usage of herbal medicines: counterindications, cross-reactivity and toxicity

Interaction of Traditional Remedies Against HIV, Nutrients and ARVs

Contact Info

Product

Resources

About