Reconstruction of composite oral and maxillofacial defects using free flaps is challenging. The key to such delicate reconstruction lies in the evaluation of the defect. However, few reports have described the clinical classification of these difficult defects. In this study, we proposed a classification method and developed different reconstructive solutions using free flap techniques according to this classification. This classification method was established based on two parameters (the elements and distribution of the missing tissues). Among the 17 patients with composite oral and maxillofacial defects included in this study, 8 patients presented with type A defects, one patient presented with a type B defect, and the other 8 patients presented with type C defects. No type D defects were observed in this study. Three types of free flaps were used to reconstruct the respective types of composite defects. Perforator-based ALT flaps were used to reconstruct Type A defects. Branch-based ALT flaps were used to reconstruct Type B defects. For Type C defects, two reconstructive solutions were used, including a well-designed fibular flap and a perforator-based ALT flap with or without a metal plate for bony reconstruction. All flaps survived after surgery. This classification system may help select and design specific free flaps for reconstructing composite oral and maxillofacial defects.Composite oral and maxillofacial defects after ablative oncological surgery, such as typical through-and-through oral defects, are challenging clinical problems for plastic and reconstructive surgeons. Multiple factors, including different related anatomical sites, multiple types of missing tissues, and sometimes even two separate defects, often cause these composite defects to be variable and complicated to reconstruct. Understanding the features or patterns of these composite defects may provide a framework to describe these defects and help plan the reconstructive algorithm. However, as we know, few studies have reported the classification of composite oral and maxillofacial defects.Surgical reconstruction for these composite defects is quite difficult because multiple types of tissue from different anatomic sites are missing 1,2 . Reconstruction of these complicated defects not only requires restoring the anatomy but also replacing the exact amount and types of missing tissue. The application of free flaps to reconstruct composite oral and maxillofacial defects has been well reported in the literature 3-7 . However, few studies have discussed choosing different reconstructive solutions and designing free flaps based on a classification of composite oral and maxillofacial defects.In the present study, we reviewed a series of patients with composite oral and maxillofacial defects and proposed a new classification method based on the elements and distribution of the missing tissues. Three types of reconstructive solutions using a free flap technique were developed accordingly. The reconstructive results using free flaps based on thi...