Chimeric Antigen Receptor T-Cell Therapy

How Fundamental Research on T cell Biology Started a Revolution in Cancer Therapy Development

“…The work of Busch and Fehleisen in the nineteenth century provides insights into the impact of discovery-based research in the immune system's role in combating neoplastic diseases (Rasheed & Koyyala, 2021). At the time, they were independently investigating ways to culture Streptococcus pyogenes, a pathogen with a long history as the causative agent of erysipelas -an infection that has rapid-onset, surface-level skin infection often affects elderly and immunocompromised individuals, newborns and young children, typically following bacterial entry through a breach in the skin (Celestin et al, 2007).…”

“…The curiosity-driven pursuit of advancing immunotherapies formed the foundation of scientific progress, leading researchers to unexpected findings and novel insights (Rasheed & Koyyala, 2021). The evolution of studying T cell biology in the context of cancer treatment highlights the critical need for sustained funding in this realm.…”