2022
DOI: 10.1021/acsinfecdis.2c00201
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Chimeric Ligands of Pili and Lectin A Inhibit Tolerance, Persistence, and Virulence Factors of Pseudomonas aeruginosa over a Wide Range of Phenotypes

Abstract: Bacteria readily form resilient phenotypes to counter environmental and antibiotic stresses. Here, we demonstrate a class of small molecules that inhibit a wide range of Pseudomonas aeruginosa phenotypes and enable antibiotics to kill previously tolerant bacteria, preventing the transition of tolerant bacteria into a persistent population. We identified two proteins, type IV pili and lectin LecA, as receptors for our molecules by methods including a new label-free assay based on bacteria… Show more

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Cited by 3 publications
(6 citation statements)
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“…Such approaches in the context of the complex CF milieu are likely to address host-pathogen interactions, bacterial aggregation, biofilm matrix development and disruption, and the novel directed-targeting of antibiotics to the CF airway P. aeruginosa. It is well-established that P. aeruginosa readily adapt to their environment and express a wide variety of phenotypes, not only in the CF population, but also over time and location in the respiratory tract of an individual, as presented in the introduction and discussed in more detail below [6,10,11,13,[15][16][17][19][20][21]28,29,31,33,41,44,117,118,130]. The heterogeneity of feature characteristics was, therefore, desired within the collection of P. aeruginosa employed so that the binding data would reflect the wide range of Pseudomonas presentations that treatment strategies would hope to address.…”
Section: Importance Of Investigating the Characteristics Diversity Of...mentioning
confidence: 99%
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“…Such approaches in the context of the complex CF milieu are likely to address host-pathogen interactions, bacterial aggregation, biofilm matrix development and disruption, and the novel directed-targeting of antibiotics to the CF airway P. aeruginosa. It is well-established that P. aeruginosa readily adapt to their environment and express a wide variety of phenotypes, not only in the CF population, but also over time and location in the respiratory tract of an individual, as presented in the introduction and discussed in more detail below [6,10,11,13,[15][16][17][19][20][21]28,29,31,33,41,44,117,118,130]. The heterogeneity of feature characteristics was, therefore, desired within the collection of P. aeruginosa employed so that the binding data would reflect the wide range of Pseudomonas presentations that treatment strategies would hope to address.…”
Section: Importance Of Investigating the Characteristics Diversity Of...mentioning
confidence: 99%
“…P. aeruginosa phenotypes from agar plates included the variety expected from CF airway specimens including the variability in pigments, fluorescence, motility, mature colony morphologies, and pearlescent extracellular matrix [6,13,14,16,18,28,29,44,131]. The collection included strains with wild-type-like motility and isolates showing host-adapted characteristics such as nonmotile nonmucoid colonies, mucoid colonies, and one small colony variant.…”
Section: Importance Of Investigating the Characteristics Diversity Of...mentioning
confidence: 99%
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