Chimioprévention et chirurgie prophylactique du cancer de l'ovaire

Deffieux, X.; Touboul, Cyril; Uzan, Catherine; Faivre, E.; Frydman, René; Fernandez, H.; Morice, Philippe

doi:10.1016/j.jgyn.2007.06.013

Cited by 4 publications

(1 citation statement)

References 55 publications

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“…L'hormonopré vention du cancer du sein est actuellement en cours d'é valuation dans cette population [15,16]. En France, sont notamment en cours deux é tudes de pré vention par les inhibiteurs de l'aromatase, mené es par la Fé dé ration nationale des centres de lutte contre le cancer.…”

Section: Place Des Centres Pluridisciplinairesunclassified

Modalités de fonctionnement d’un centre de suivi des femmes à haut risque de cancer du sein et de l’ovaire : une expérience à l’hôpital Tenon

Chabbert-Buffet¹,

Séroussi²,

Chopier³

et al. 2010

Gynécologie Obstétrique & Fertilité

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Section: Place Des Centres Pluridisciplinairesunclassified

Modalités de fonctionnement d’un centre de suivi des femmes à haut risque de cancer du sein et de l’ovaire : une expérience à l’hôpital Tenon

Chabbert-Buffet¹,

Séroussi²,

Chopier³

et al. 2010

Gynécologie Obstétrique & Fertilité

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The modern pharmacology of paracetamol: therapeutic actions, mechanism of action, metabolism, toxicity and recent pharmacological findings

et al. 2013

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Paracetamol is used worldwide for its analgesic and antipyretic actions. It has a spectrum of action similar to that of NSAIDs and resembles particularly the COX-2 selective inhibitors. Paracetamol is, on average, a weaker analgesic than NSAIDs or COX-2 selective inhibitors but is often preferred because of its better tolerance. Despite the similarities to NSAIDs, the mode of action of paracetamol has been uncertain, but it is now generally accepted that it inhibits COX-1 and COX-2 through metabolism by the peroxidase function of these isoenzymes. This results in inhibition of phenoxyl radical formation from a critical tyrosine residue essential for the cyclooxygenase activity of COX-1 and COX-2 and prostaglandin (PG) synthesis. Paracetamol shows selectivity for inhibition of the synthesis of PGs and related factors when low levels of arachidonic acid and peroxides are available but conversely, it has little activity at substantial levels of arachidonic acid and peroxides. The result is that paracetamol does not suppress the severe inflammation of rheumatoid arthritis and acute gout but does inhibit the lesser inflammation resulting from extraction of teeth and is also active in a variety of inflammatory tests in experimental animals. Paracetamol often appears to have COX-2 selectivity. The apparent COX-2 selectivity of action of paracetamol is shown by its poor anti-platelet activity and good gastrointestinal tolerance. Unlike both non-selective NSAIDs and selective COX-2 inhibitors, paracetamol inhibits other peroxidase enzymes including myeloperoxidase. Inhibition of myeloperoxidase involves paracetamol oxidation and concomitant decreased formation of halogenating oxidants (e.g. hypochlorous acid, hypobromous acid) that may be associated with multiple inflammatory pathologies including atherosclerosis and rheumatic diseases. Paracetamol may, therefore, slow the development of these diseases. Paracetamol, NSAIDs and selective COX-2 inhibitors all have central and peripheral effects. As is the case with the NSAIDs, including the selective COX-2 inhibitors, the analgesic effects of paracetamol are reduced by inhibitors of many endogenous neurotransmitter systems including serotonergic, opioid and cannabinoid systems. There is considerable debate about the hepatotoxicity of therapeutic doses of paracetamol. Much of the toxicity may result from overuse of combinations of paracetamol with opioids which are widely used, particularly in USA.

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Cœlioscopie monotrocart versus micro-cœlioscopie dans la chirurgie annexielle bénigne : résultats d’une étude pilote non randomisée

Peretti¹,

Chereau

Lambaudie

et al. 2016

Gynécologie Obstétrique & Fertilité

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Chimioprévention et chirurgie prophylactique du cancer de l'ovaire

Cited by 4 publications

References 55 publications

Modalités de fonctionnement d’un centre de suivi des femmes à haut risque de cancer du sein et de l’ovaire : une expérience à l’hôpital Tenon

Modalités de fonctionnement d’un centre de suivi des femmes à haut risque de cancer du sein et de l’ovaire : une expérience à l’hôpital Tenon

The modern pharmacology of paracetamol: therapeutic actions, mechanism of action, metabolism, toxicity and recent pharmacological findings

Cœlioscopie monotrocart versus micro-cœlioscopie dans la chirurgie annexielle bénigne : résultats d’une étude pilote non randomisée

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