Health diplomacy has remained an important part of foreign policy of major countries to expand their geopolitical influence across the world. Given the outbreak of COVID-19, the inadequate healthcare systems even of the developed countries have been exposed. Although China was blamed for the origination of COVID-19, concomitantly, the same country had exploited the global health emergency by putting its global health diplomacy in practice as a soft power tool to expand its geopolitical influence in term of hegemony, vis-→-vis the USA. Whereas, on the contrary, the USA and European Union (EU) have been critically entrapped in the pandemic and remained at crossroads, how to deal with the same locally and globally. In these contrasting roles and reciprocation, the main argument of the article is that China had made the best use of its health diplomacy to expand its geopolitical influence, while the USA and EU did not rise to the occasion; rather, their roles and reciprocation have remained delayed and inert. In this backdrop, the main focus of this article is to examine how China used its global health diplomacy as a soft power tool? Second, would China become hegemon in the present scenario vis-→-vis the USA?