China's medical research integrity

Tian, Xu; Song, Guo-Min

doi:10.1016/s0140-6736(15)00410-9

Cited by 7 publications

(3 citation statements)

References 4 publications

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“…This was the main reason for introducing non-English studies in our meta-analysis. Although the reliability of the Chinese studies is being questioned (Tian and Song, 2015), it is hardly possible to omit these publications arbitrarily, especially given the robustness of increasing publications in Chinese that provide a large number of disease cases. Furthermore, excluding any non-English publication may cause a significant publication bias towards studies with significance results more likely to be published in English (Egger, 1997).…”

Section: Discussionmentioning

confidence: 99%

Lamotrigine augmentation in treatment-resistant unipolar depression: A comprehensive meta-analysis of efficacy and safety

et al. 2019

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Objective: Augmentation strategies are commonly applied when an individual is unresponsive to antidepressant monotherapy. Lamotrigine is currently considered at best only as second line augmentation for treatment-resistant unipolar depression while its clinical efficacy and safety profiles remain inconclusive. We intended to assess the therapeutic effects and safety profiles of lamotrigine augmentation in patients with treatment-resistant unipolar depression by conducting a meta-analysis. Methods: MEDLINE, Embase, EBSCO, Cochrane, Web of Science, Scopus, Wanfang and Ariniti databases were searched. Coprimary outcomes, including changes in severity of depression and response rate, were measured in this study. Secondary outcomes were defined as the safety profile of the intervention, including reported discontinuation rate and adverse events. Results: Eight double-blinded randomized controlled trials with 677 patients overall were included. Significant improvements in Hamilton Rating Scale for Depression scores and response rates were shown in lamotrigine augmentation groups compared with control groups, of which the pooled result of six Chinese studies showed positive effects of Hamilton Rating Scale for Depression improvement while the pooled result of two non-Chinese studies was statistically non-significant. Patients with more severe illness and longer duration of illness were more effectively treated with lamotrigine augmentation. The magnitude of depression improvement after lamotrigine augmentation was higher in patients treated with selective serotonin reuptake inhibitors than those treated with serotonin-norepinephrine reuptake inhibitors. Lamotrigine augmentation is well-tolerated in terms of all-cause discontinuation rate and adverse events. Conclusions: Lamotrigine augmentation may serve as a possible choice for patients with treatment-resistant unipolar depression and further trials are warranted to clarify the optimal dosage of lamotrigine augmentation together with the treatment duration and safety over time.

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Section: Discussionmentioning

confidence: 99%

Lamotrigine augmentation in treatment-resistant unipolar depression: A comprehensive meta-analysis of efficacy and safety

et al. 2019

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“…As described in Science , specialized companies in China sell ‘first’ or ‘corresponding’ author slots for thousands of dollars, the amount depending on the impact factor and reputation of the respective journal (Hvistendahl, ). While this phenomenon is unlikely to be limited to one market (Tian and Song, ), the authors of these articles analyzed possible reasons and explanations for why the pressure for publication in reputed journals might be particularly high in China. The documentation of such cases, along with media coverage of exceptionally brazen examples of scientific fraud, has shattered the public trust in science, and contrasts how science was regarded ‘then’ and ‘now’.…”

Section: Authorshipmentioning

confidence: 99%

The challenges for scientific publishing, 60 years on

Hausmann

Murphy

2016

Journal of Neurochemistry

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The most obvious difference in science publishing between 'then' and 'now' is the dramatic change in the communication of data and in their interpretation. The democratization of science via the Internet has brought not only benefits but also challenges to publishing including fraudulent behavior and plagiarism, data and statistics reporting standards, authorship confirmation and other issues which affect authors, readers, and publishers in different ways. The wide accessibility of data on a global scale permits acquisition and meta-analysis to mine for novel synergies, and has created a highly commercialized environment. As we illustrate here, identifying unacceptable practices leads to changes in the standards for data reporting.

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“…Regrettably, a handful of researchers have resorted to improper methods such as plagiarism and falsification in order to publish their papers and gain recognition. Once exposed, their misconduct has caused a ripple effect leading to the retraction of their papers, ultimately harming the academic reputation of scientific community (Tian & Song, 2015).…”

Section: Introductionmentioning

confidence: 99%

Research misconduct in hospitals is spreading: A bibliometric analysis of retracted papers from Chinese university-affiliated hospitals

Yuan,

Liu

2023

Journal of Data and Information Science

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Purpose The number of retracted papers from Chinese university-affiliated hospitals is increasing, which has raised much concern. The aim of this study is to analyze the retracted papers from university-affiliated hospitals in mainland China from 2000 to 2021. Design/methodology/approach Data for 1,031 retracted papers were identified from the Web of Science Core collection database. The information of the hospitals involved was obtained from their official websites. We analyzed the chronological changes, journal distribution, discipline distribution and retraction reasons for the retracted papers. The grade and geographic locations of the hospitals involved were explored as well. Findings We found a rapid increase in the number of retracted papers, while the retraction time interval is decreasing. The main reasons for retraction are plagiarism/self-plagiarism (n=255), invalid data/images/conclusions (n=212), fake peer review (n=175) and honesty error(n=163). The disciplines are mainly distributed in oncology (n=320), pharmacology & pharmacy (n=198) and research & experimental medicine (n=166). About 43.8% of the retracted papers were from hospitals affiliated with prestigious universities. Research limitations This study fails to differentiate between retractions due to honest error and retractions due to research misconduct. We believe that there is a fundamental difference between honest error retractions and misconduct retractions. Another limitation is that authors of the retracted papers have not been analyzed in this study. Practical implications This study provides a reference for addressing research misconduct in Chinese university-affiliated hospitals. It is our recommendation that universities and hospitals should educate all their staff about the basic norms of research integrity, punish authors of scientific misconduct retracted papers, and reform the unreasonable evaluation system. Originality/value Based on the analysis of retracted papers, this study further analyzes the characteristics of institutions of retracted papers, which may deepen the research on retracted papers and provide a new perspective to understand the retraction phenomenon.

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China's medical research integrity

Cited by 7 publications

References 4 publications

Lamotrigine augmentation in treatment-resistant unipolar depression: A comprehensive meta-analysis of efficacy and safety

Lamotrigine augmentation in treatment-resistant unipolar depression: A comprehensive meta-analysis of efficacy and safety

The challenges for scientific publishing, 60 years on

Research misconduct in hospitals is spreading: A bibliometric analysis of retracted papers from Chinese university-affiliated hospitals

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