China's sustained drive to eliminate neglected tropical diseases

Yang, Guo-Jing; Liu, Lu; Zhu, Hongru; Griffiths, Siân; Tanner, Marcel; Bergquist, Robert; Utzinger, Jürg; Zhou, Xiao‐Nong

doi:10.1016/s1473-3099(14)70727-3

Cited by 106 publications

(84 citation statements)

References 70 publications

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“…Having already successfully pioneered multi-component integrated strategies, which included health education, for the control of other NTDs such as lymphatic filariasis and schistosomiasis [17–20], the Chinese authorities are in an ideal position to undertake a multi-component integrated public health strategy that combines mass drug administration (MDA) with health education and improved WASH for the control of STH in rural China. Based on the national-scale experience, China would then be in a good position to help implement such projects in other countries.…”

Section: Resultsmentioning

confidence: 99%

Health education and the control of intestinal worm infections in China: a new vision

McManus

Bieri

et al. 2014

Parasit Vectors

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BackgroundThe transmission of soil-transmitted helminths (STHs) is associated with poverty, poor hygiene behaviour, lack of clean water and inadequate waste disposal and sanitation. Periodic administration of benzimidazole drugs is the mainstay for global STH control but it does not prevent re-infection, and is unlikely to interrupt transmission as a stand-alone intervention.FindingsWe reported recently on the development and successful testing in Hunan province, PR China, of a health education package to prevent STH infections in Han Chinese primary school students. We have recently commenced a new trial of the package in the ethnically diverse Xishuangbanna autonomous prefecture in Yunnan province and the approach is also being tested in West Africa, with further expansion into the Philippines in 2015.ConclusionsThe work in China illustrates well the direct impact that health education can have in improving knowledge and awareness, and in changing hygiene behaviour. Further, it can provide insight into the public health outcomes of a multi-component integrated control program, where health education prevents re-infection and periodic drug treatment reduces prevalence and morbidity.

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Section: Resultsmentioning

confidence: 99%

Health education and the control of intestinal worm infections in China: a new vision

McManus

Bieri

et al. 2014

Parasit Vectors

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“…China over the past 10–15 years due to socioeconomic development and large-scale interventions [38]. However, clonorchiasis, the major food-borne trematodiases in P.R.…”

Section: Discussionmentioning

confidence: 99%

Risk mapping of clonorchiasis in the People’s Republic of China: A systematic review and Bayesian geostatistical analysis

et al. 2017

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BackgroundClonorchiasis, one of the most important food-borne trematodiases, affects more than 12 million people in the People’s Republic of China (P.R. China). Spatially explicit risk estimates of Clonorchis sinensis infection are needed in order to target control interventions.MethodologyGeoreferenced survey data pertaining to infection prevalence of C. sinensis in P.R. China from 2000 onwards were obtained via a systematic review in PubMed, ISI Web of Science, Chinese National Knowledge Internet, and Wanfang Data from January 1, 2000 until January 10, 2016, with no restriction of language or study design. Additional disease data were provided by the National Institute of Parasitic Diseases, Chinese Center for Diseases Control and Prevention in Shanghai. Environmental and socioeconomic proxies were extracted from remote-sensing and other data sources. Bayesian variable selection was carried out to identify the most important predictors of C. sinensis risk. Geostatistical models were applied to quantify the association between infection risk and the predictors of the disease, and to predict the risk of infection across P.R. China at high spatial resolution (over a grid with grid cell size of 5×5 km).Principal findingsWe obtained clonorchiasis survey data at 633 unique locations in P.R. China. We observed that the risk of C. sinensis infection increased over time, particularly from 2005 onwards. We estimate that around 14.8 million (95% Bayesian credible interval 13.8–15.8 million) people in P.R. China were infected with C. sinensis in 2010. Highly endemic areas (≥ 20%) were concentrated in southern and northeastern parts of the country. The provinces with the highest risk of infection and the largest number of infected people were Guangdong, Guangxi, and Heilongjiang.Conclusions/SignificanceOur results provide spatially relevant information for guiding clonorchiasis control interventions in P.R. China. The trend toward higher risk of C. sinensis infection in the recent past urges the Chinese government to pay more attention to the public health importance of clonorchiasis and to target interventions to high-risk areas.

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“…These efforts were made possible through collaborations with the WHO, private donors and other non-governmental organisations 20. In order to be successful, the political will for disease control must be sustained, the operations must be scaled up, the partnership between governmental and non-governmental organisations needs to be strengthened, and national institutional capacity must be strengthened 8 14 17 21…”

Section: Global Health Problem Analysismentioning

confidence: 99%

Factors affecting illness in the developing world: chronic disease, mental health and traditional medicine cures

Douthit

Alemu

2016

BMJ Case Reports

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This is a case report of a 24-year-old Ethiopian woman with a medical history of hepatosplenic schistosomiasis. She suffers from chronic liver failure and portal hypertension. She has been hospitalised for 'hysteria' in the past but did not receive follow-up, outpatient treatment or psychiatric evaluation. After discontinuing her medications and leaving her family to use holy water, a religious medicine used by many Ethiopians, she was found at a nearby monastery. She was non-communicative and difficult to arouse. The patient was rushed to nearby University of Gondar Hospital where she received treatment for hepatic encephalopathy and spontaneous bacterial peritonitis. Her illness is the result of neglected tropical disease, reliance on traditional medicine as opposed to biomedical services and the poor state of psychiatric care in the developing world.

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China's sustained drive to eliminate neglected tropical diseases

Cited by 106 publications

References 70 publications

Health education and the control of intestinal worm infections in China: a new vision

Health education and the control of intestinal worm infections in China: a new vision

Risk mapping of clonorchiasis in the People’s Republic of China: A systematic review and Bayesian geostatistical analysis

Factors affecting illness in the developing world: chronic disease, mental health and traditional medicine cures

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