Chinese and global burdens of gastric cancer from 1990 to 2019

Abstract

BackgroundGastric cancer is a common cancer in China. This project investigated the disease burden of gastric cancer from 1990 to 2019 in China and globally.MethodsThe global age‐standardized rates (ASRs) were extracted from the Global Burden of Disease. Moreover, the estimated annual percentage changes (eAPCs) in the ASRs of incidence (ASIR), mortality (ASMR), and disability‐adjusted life‐years (DALYs) were calculated to determine the trends by countries and regions.ResultsIn China, the ASIR declined from 37.56 to 30.64 per 100,000 and the ASMR declined from 37.73 to 21.72 per 100,000. The global ASIR decreased from 22.44 to 15.59 and the ASMR declined from 20.48 to 11.88 per 100,000 persons from 1990 to 2019. The ASIR was the lowest in Malawi (3.28 per 100,000) and the highest in Mongolia (43.7 per 100,000), whereas the ASMR was the lowest in the United States of America (3.40 per 100,000) and the highest in Mongolia (40.04 per 100,000) in 2019. The incidence of early‐onset gastric cancer increased in China. The DALYs attributed to gastric cancer presented a slight decrease during the period. China had a higher mortality/incidence ratio (0.845) and 5‐year prevalence (27.6/100,000) than most developed countries.ConclusionChina presented a steady decline in the incidence and mortality rates for gastric cancer. The global ASIR, ASMR, and DALYs showed a slight rise decrease. Different patterns of gastric cancer rates and temporal trends have been identified in different geographical regions, indicating that specific strategies are needed to prevent the increase in some countries.

The Chinese Society of Clinical Oncology (CSCO): Clinical guidelines for the diagnosis and treatment of gastric cancer, 2021

“…The disease burden of gastric cancer in China is high. According to the Global Burden of Disease Study 2019, the disability‐adjusted life‐years (DALYs) in China accounted for 44.21% of the total number of gastric cancer worldwide [ 2 ]. Gastric cancer is the second most frequently diagnosed cancer and the second leading cause of cancer‐related deaths in China.…”

Differences in the Association Between Modifiable Lifestyle Factors and Gastric Precancerous Lesions Among Mongolians and Han Chinese

“…( 3 ) Furthermore, although Mongolians had a significantly lower proportion of insufficient intake of vegetables and fruits than Han Chinese (80·6% vs· 82·2%), the association between GPL and vegetables and fruits consumption was more evident for Mongolians (P < 0·05). The results of this study contrast with some previous studies that claimed vitamins, minerals, and antioxidants from fruits and vegetables could prevent gastric cancer by modulating DNA methylation and inhibiting gastric cancer cell growth ( 34 ).…”

“…Specifically, GC has become a rising public health concern in China. Over the past two decades, China has witnessed a substantial rise in GC incidence rates, disease burdens, and mortality rates ( 3 ). Invasive gastric carcinoma is often preceded by a series of degrading conditions known as gastric precancerous lesion (GPL), including gastric ulcers (GU), atrophic gastritis (AG), intestinal metaplasia (IM), and dysplasia.…”

Distribution characteristics of the sabA, hofC, homA, homB and frpB-4 genes of Helicobacter pylori in different regions of China

“…pylori is one of the causes of gastric cancer (GC), which is the second most common cancer in China. Shandong (30.50/100000) and Qinghai (48.76/100000) provinces are considered to have a high incidence of GC, while Heilongjiang (15.53/100000), Guangxi (19.68/100000) and Hunan (10-20/100000) provinces have a relatively low incidence of GC [ 15 , 16 ]. Meanwhile, the economic development level, living environment and dietary habits of these selected regions are quite different, which is more helpful for us to analyze the diversity of H .…”