Chinese Guidelines for the Diagnosis and Management of Tumefactive Demyelinating Lesions of Central Nervous System

doi:10.4103/0366-6999.211547

Cited by 11 publications

(9 citation statements)

References 56 publications

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“…CBF, as measured by ASL, is usually decreased in demyelinating lesions, while it is usually increased in high-grade gliomas [14] . Similar to our findings, regional hypoperfusion with possible mild central hyperperfusion, presumably related to a deep venule, has been described in BCS [7] .…”

Section: Discussionmentioning

confidence: 97%

Advanced neuroimaging in Balo's concentric sclerosis: MRI, MRS, DTI, and ASL perfusion imaging over 1 year

Yeo

Hutton

Fung

2018

Radiology Case Reports

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Balo concentric sclerosis (BCS) is a rare, atypical demyelinating disease, which may rapidly progress to become severe and fatal. Advanced neuroimaging has proven helpful for early diagnosis, classification, prognostication, and monitoring of progression in multiple sclerosis, but has not been fully explored in BCS. We present the case of a 27-year-old woman with BCS in whom advanced neuroimaging was used to correlate the evolution of disease with clinical findings over the course of 1 year. Magnetic resonance imaging, magnetic resonance spectroscopy (MRS), diffusion tensor imaging (DTI), and arterial spin labeling cerebral perfusion were obtained at presentation (Day 0), and at Day 67 and Day 252. Imaging features include multilayered concentric ring lesion, reduced diffusion along the rim, hypoperfusion with possible mild central hyperperfusion, and MRS findings of increased choline, decreased N-acetylaspartate (NAA), and possible presence of lactate and/or lipid peak. DTI tractography and relative apparent diffusion coefficient analyses correlated with clinical symptoms and may help to determine extent of white matter tract injury and prognosis.

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Section: Discussionmentioning

confidence: 97%

Advanced neuroimaging in Balo's concentric sclerosis: MRI, MRS, DTI, and ASL perfusion imaging over 1 year

Yeo

Hutton

Fung

2018

Radiology Case Reports

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“…Our study presents one of the rare cases that TDLs were found on the MRI as the first clinical and radiographical event without any pre-existing inflammatory demyelinating diseases of the CNS [ 5 ]. Its course is uncommon and often manifests variably that are resembling the brain neoplasms [ 2 , 3 ]; thus, it becomes a challenge for clinicians to be able to establish the diagnosis of TDLs. Some studies report that TDLs often occur at 20–30 years of life [ 3 , 5 , 8 ], although Kim et al reported that the onset of symptoms occurs averagely at 42 years [ 9 ].…”

Section: Discussionmentioning

confidence: 99%

“…Tumefactive demyelinating lesions (TDLs) are a special type of inflammatory disease of the central nervous system (CNS) that occur in patients with or without the presence of a definitive neurological disorders, most often found in multiple sclerosis (MS) [ 1 , 2 ]. On neuroimaging, it typically manifests as a tumor-like lesion or mass with a diameter greater than 2 cm, with or without the involvement of mass effect, edema, and ring enhancement after contrast medium administration [ 1 ].…”

Section: Introductionmentioning

confidence: 99%

“…The establishment of diagnosis has become a challenge because of its nature of clinical and radiological manifestations, which are usually mimicking brain neoplasm [ 2 ]. Currently, magnetic resonance imaging (MRI) is the main modality used for the diagnosis of TDLs and also helpful to differentiate other demyelinating disorders [ 2 , 6 ]. In our study, we describe a case of brain TDLs in male patient presented with a new onset of impaired consciousness.…”

Section: Introductionmentioning

confidence: 99%

“…Decade of 2 and 3 years of life is the range that is commonly known to be affected by TDLs [3,5]. The establishment of diagnosis has become a challenge because of its nature of clinical and radiological manifestations, which are usually mimicking brain neoplasm [2]. Currently, magnetic resonance imaging (MRI) is the main modality used for the diagnosis of TDLs and also helpful to differentiate other demyelinating disorders [2,6].…”

Section: Introductionmentioning

confidence: 99%

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Neuroimaging features of tumefactive demyelinating lesions: A rare case report

Febyan

Sutrisno

Ronny

et al. 2020

European Journal of Radiology Open

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Tumefactive demyelinating lesion is a special type of neuro-inflammatory disease with unusual variants to be found in magnetic resonance imaging. It manifests as a solitary or multiple lesion greater than 2 cm in diameter and often clinically challenging because of its varieties of symptoms. We present a rare case of a 40-year-old male, presented with initial complaints of headache and unconsciousness. Yet, the physical examination findings showed normal results. Magnetic resonance imaging revealed a tumefactive demyelinating lesion suspected with brain neoplasm.

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