Chinese health biotech and the billion-patient market

Frew, Sarah E.; Sammut, Stephen M.; Shore, Alysha F; Ramjist, Joshua; Al-Bader, Sara; Rezaie, Rahim; Daar, Abdallah S.; Сингер, Петер

doi:10.1038/nbt0108-37

Cited by 91 publications

(60 citation statements)

References 11 publications

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“…Помимо Oncorine™, компания Shanghai Sunway Biotech разработала другие препараты на осно-ве генетически модифицированных аденовирусов -Н102 и Н103 для лечения больных со злокачественными новообразованиями [57]. В препарате Н102 экспрессия аденовирусного гена Е1а находится под контролем про-мотора α-фетопротеина, который значительно активи-рован в первичных гепатоцеллюлярных карциномах, но не в нормальных клетках.…”

Section: Oncorine™ (н-101) в 2005 г китайской регулирующей организацunclassified

“…К настоящему времени прошла I фаза клиниче-ских испытаний препарата Н103 с включением 27 боль-ных с распространенными опухолевыми заболеваниями. В 11,1% случаев отмечен объективный положительный ответ (полный + частичный ответ) и в 37% случаев -ста-билизация процесса [57].…”

Section: Oncorine™ (н-101) в 2005 г китайской регулирующей организацunclassified

See 1 more Smart Citation

Official Medications for Anti-Tumor Gene Therapy

Немцова¹,

Безбородова²,

Якубовская³

et al. 2016

Issled. prakt. med. (Print)

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Section: Oncorine™ (н-101) в 2005 г китайской регулирующей организацunclassified

Official Medications for Anti-Tumor Gene Therapy

Немцова¹,

Безбородова²,

Якубовская³

et al. 2016

Issled. prakt. med. (Print)

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“…Herba epimedii and its complex formulations, such as Xianling Gubao capsules, are widely used in China for the treatment of osteoporosis, coronary artery disease, male sexual dysfunction, acute myocardial ischemia, and asthmatic cough. [1][2][3][4] Modern pharmacology shows that icariin performs a lot of pharmacological and biological activities, which include preventing osteoporosis, protecting neurons, facilitating penile erection, and performing anti-cancer, anti-depression, and hypouricemic action. [5][6][7][8][9][10] However, poor bioavailability of icariin is a significant barrier to its clinical application.…”

Section: Introductionmentioning

confidence: 99%

Changes in the intestinal absorption mechanism of icariin in the nanocavities of cyclodextrins

Zhang¹,

Wang²,

Cui³

et al. 2012

IJN

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Icariin is a bioactive herbal ingredient isolated from Herba epimedii, which has been widely used for the treatment of osteoporosis and male sexual dysfunction in traditional Chinese medicine. The major objective of this work is to investigate the different enhancing effects of β-cyclodextrin (β-CD) and hydroxypropyl-β-cyclodextrin (HP-β-CD) on the intestinal absorption of icariin, and to identify the molecular mechanisms of this action. Host-guest-type interactions of icariin with cyclodextrins nanocavities were unambiguously demonstrated by the phase-solubility diagram, ultraviolet spectroscopy, Fourier transform infrared spectroscopy, differential scanning calorimetry, X-ray powder diffractometry, and two dimensional proton nuclear magnetic resonance rotating-frame Overhauser effect spectroscopy. These results were further supported using molecular modeling studies. The rat single-pass intestinal perfusion model showed that the absorption of icariin was affected by P-glycoprotein (Pgp). The icariin/ HP-β-CD inclusion complex provided greater enhancement in the intestinal absorption than the icariin/β-CD inclusion complex. Therefore, the enhancing effect was involved in a solubilizing effect and/or Pgp inhibitory effect. Finally, fluorescence anisotropy measurements and Pgp adenosine triphosphatase (ATPase) assay demonstrated that β-CD exhibited no effect on Pgp, while HP-β-CD showed inhibition by restraining the Pgp ATPase activity rather than changing the fluidity of cell membrane.

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“…The first Oncolytic virus to be approved by a regulatory agency was a genetically modified adenovirus named H101 by Shanghai Sunway Biotech. It gained regulatory approval in 2005 from China's State Food and Drug Administration (SFDA) for the treatment of head and neck cancer [5,6]. Sunway's H101 and the very similar Onyx-15 have been engineered to remove a viral defense mechanism that interacts with a normal human gene p53, which is very frequently deregulated in cancer cells [6].…”

Section: Introductionmentioning

confidence: 99%

Mathematical Modeling and Analysis of Tumor Therapy with Oncolytic Virus

Agarwal¹,

Bhadauria²

2011

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In this paper, we have proposed and analyzed a nonlinear mathematical model for the study of interaction between tumor cells and oncolytic viruses. The model is analyzed using stability theory of differential equations. Positive equilibrium points of the system are investigated and their stability analysis is carried out. Moreover, the numerical simulation of the proposed model is also performed by using fourth order RungeKutta method which supports the theoretical findings. It is found that both infected and uninfected tumor cells and hence tumor load can be eliminated with time, and complete recovery is possible because of virus therapy, if certain conditions are satisfied. It is further found that the system appears to exhibit periodic limit cycles and chaotic attractors for some ranges of the system parameters.

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Chinese health biotech and the billion-patient market

Cited by 91 publications

References 11 publications

Official Medications for Anti-Tumor Gene Therapy

Official Medications for Anti-Tumor Gene Therapy

Changes in the intestinal absorption mechanism of icariin in the nanocavities of cyclodextrins

Mathematical Modeling and Analysis of Tumor Therapy with Oncolytic Virus

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