Chinese herbal fumigant and lotion for postoperative complication in surgical wound of anal fistula

Abstract

Background: Surgery is the most common and effective therapy for anal fistula, while the postoperative complication, such as pain, edema, pruritus, turgescence, and exudation in surgical wound, can have serious impact on wound healing and patients’ quality of life. Chinese herbal fumigant and lotion have been commonly used in postoperative treatment and achieved satisfied effect in China. However, clinical evidence-based literature of Chinese herbal fumigant and lotion for postoperative anal fistula is not sufficient. This protocol is described for a systematic review to investigate the beneficial effects. Methods: A systematic search will be conducted in database involving PubMed, the Cochrane library, Embase, Web of Science, Google Scholar, SinoMed, China National Knowledge Infrastructure(CNKI), VIP, Wanfang Database, CiNii(National Institute of Informatics), and KISS(Koreanstudies Information Service System) from inceptions to December 31, 2019. We will include randomized controlled trials (RCT) regarding Chinese herbal fumigant and lotion in the treatment of complication in surgical wound of anal fistula. Quality of included RCTs will be assessed according to the Cochrane Handbook 5.1.0. GRADE will be used to assess the quality of evidence. The summary results will be pooled using the random-effects model or fixed-effects model according to the heterogeneity of included studies. Results: After peer-review, the study will be disseminated in scientific journals and conferences. Conclusion: This systematic review will provide evidence for the efficacy of Chinese herbal fumigant and lotion for curing postoperative complication of anal fistula. In addition, it might provide suggestions for Chinese medicine clinical practice or guideline. PROSPERO registration: CRD42020164975.

[Retracted] Evaluation of the Effectiveness of a Combination of Chinese Herbal Fumigation Sitz‐Bath and Red Ointment in Managing Postoperative Wound Healing and Pain Control in Anal Fistula Patients

“…Previous scholars have used iodophor, infrared radiation, potassium permanganate, and other methods for treatment of anal fistula, but the effect is not ideal [ 16 ]. Studies by [ 17 ] utilizing the Chinese herbal fumigant with lotion for curing postoperative wounds in anal fistula with results showing great efficacy. Zhang et al [ 14 ] showed that Chinese medicine helps patients recover faster and has fewer side effects than Western medicines.…”

Efficacy and safety of traditional Chinese medicine external washing in the treatment of postoperative wound of diabetes complicated with anal fistula: Study protocol of a randomized, double-blind, placebo-controlled, multi-center clinical trial

“…However, diabetic patients with large wounds after anal fistula surgery have an increased probability of wound infection, accompanied by pain, itching, swelling, and exudation, which are not easy to heal. Therefore, it is particularly important to shorten the wound healing time ( Yang et al, 2017 ; Zhu et al, 2020 ).…”

Study on anti-inflammatory and healing mechanism of Jiawei Shengji Yuhong ointment on wound based on NF-κBp65 / IL-1β / VEGF pathway

“…However, the perianal skin is tender, and the anal pain nerve is rich. Moreover, due to the need for defecation every day, the postoperative wound is not only polluted by feces, but also the mechanical damage in the defecation process will aggravate the trauma of the postoperative wound of anal stula, resulting in the slow healing of the postoperative wound of anal stula, which seriously affects the rest, eating and activity of patients, thereby affecting the postoperative recovery [8,9]. How to promote wound healing after anal stula surgery has become an important issue for clinicians.…”