Chinese herbal injection for cardio-cerebrovascular disease: Overview and challenges

Jiang, Huajuan; Xulong, Huang; Xian, Bin; Wang, Yue; Zhou, Yonggang; Ren, Chaoxiang; Pei, Jin

doi:10.3389/fphar.2023.1038906

Cited by 14 publications

(6 citation statements)

References 148 publications

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“…Pimenov and Kljuykov. Exerts anti-apoptotic effects and protects cardiomyocytes by regulating phosphatidylinositol 3-kinase/protein kinase B ( Li et al, 2023 ), and inhibits the JAK kinase/signal transducer activator of transcription signaling pathway of hypertrophic cardiomyocytes to improve ventricular remodeling ( Huajuan et al, 2023 ). Cinnamaldehyde in N. cassia (L.) Kosterm.…”

Section: Discussionmentioning

confidence: 99%

Efficacy and safety of Shen Gui capsules for chronic heart failure: a systematic review and meta-analysis

Yan,

Zhang,

Wang

et al. 2024

Front. Pharmacol.

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BackgroundAlthough Shen Gui capsules (SGCP) are widely used as an adjuvant treatment for chronic heart failure (CHF), their clinical efficacy and safety remain controversial.PurposeTo assess the efficacy and safety of SGCP in the treatment of CHF through a systematic review and meta-analysis, to provide high-quality evidence for evidence-based medicine.MethodsSeven databases were searched for randomized controlled trials (RCTs) assessing SGCP for CHF, from inception to 9 January 2023. RCT quality of evidence was evaluated using the Cochrane Handbook for the Evaluation of Intervention Systems to assess risk of bias and Grading of Recommendations Assessment, Development, and Evaluation. A meta-analysis with subgroup and sensitivity analyses was performed using Review Manager 5.4 and Stata 12.ResultsNine RCTs representing 888 patients with CHF were included in the review. Meta-analysis revealed that SGCP combined with conventional heart failure therapy is more advantageous for improving left ventricular ejection fraction [LVEF; mean difference (MD) = 5.26, 95% confidence interval (CI) (3.78, 6.74), p < 0.0000] and increasing effective rate [relative risk (RR) = 1.21, 95%CI (1.14, 1.29), p < 0.001] compared with conventional therapy alone. The experimental treatment also reduced brain natriuretic peptide [MD = −100.15, 95%CI (−157.83, −42.47), p = 0.0007], left ventricular end-diastolic diameter [MD = −1.93, 95%CI (−3.22, −0.64), p = 0.003], and hypersensitive C-reactive protein [MD = −2.70, 95%CI (−3.12,−2.28), p < 0.001] compared with the control group. However, there was not a statistically significant difference in tumor necrosis factor-α [MD = −14.16, 95%CI (−34.04, 5.73), p = 0.16] or left ventricular end-systolic diameter [MD = −1.56, 95%CI (−3.13, 0.01), p = 0.05]. Nor was there a statistically significant between-groups difference in incidence of adverse events (p > 0.05).ConclusionSGCP combined with conventional heart failure therapy can improve LVEF and increase the effective rate to safely treat patients with CHF. However, further high-quality studies are needed to confirm these findings, due to the overall low quality of evidence in this literature.Clinical Trial Registration:https://www.crd.york.ac.uk/PROSPERO/logout.php, PROSPERO [CRD42023390409].

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Section: Discussionmentioning

confidence: 99%

Efficacy and safety of Shen Gui capsules for chronic heart failure: a systematic review and meta-analysis

Yan,

Zhang,

Wang

et al. 2024

Front. Pharmacol.

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“…It should also be emphasized that a number of the substances described below have not been registered as medicinal products by the FDA and the European Medicines Agency [ 90 , 91 ]. In TCM, these substances are attributed with anti-inflammatory effects (osthole [ 92 , 93 , 94 , 95 , 96 , 97 ], flavonoids [ 98 , 99 , 100 ]); have been proposed for use in heart disease (salvianolic acid C [ 101 , 102 ]), rheumatoid arthritis (sinomenine [ 103 ]), cardiovascular disease, gastrointestinal and respiratory infections (baicalin [ 104 ]); however, they also have very broad and non-specific indications (liquiritin [ 105 ], praeruptorin A [ 106 ], piperine [ 107 ], rosmarinic acid [ 108 ]).…”

Section: Traditional Chinese Medicines and Plant-derived Compoundsmentioning

confidence: 99%

Modulation of the Mas-Related G Protein-Coupled Receptor X2 (MRGPRX2) by Xenobiotic Compounds and Its Relevance to Human Diseases

Dziadowiec,

Popiolek,

Kwitniewski

et al. 2024

JoX

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Mast cells (MCs) are immune cells that reside in tissues; particularly in the skin, and in the gastrointestinal and respiratory tracts. In recent years, there has been considerable interest in the Mas-Related G Protein-Coupled Receptor X2 (MRGPRX2), which is present on the surface of MCs and can be targeted by multiple exogenous and endogenous ligands. It is potentially implicated in non-IgE-mediated pseudoallergic reactions and inflammatory conditions such as asthma or atopic dermatitis. In this paper, we review natural products and herbal medicines that may potentially interact with MRGPRX2. They mainly belong to the classes of polyphenols, flavonoids, coumarins, and alkaloids. Representative compounds include rosmarinic acid, liquiritin from licorice extract, osthole, and sinomenine, respectively. While evidence-based medicine studies are still required, these compounds have shown diverse effects, such as antioxidant, analgesic, anti-inflammatory, or neuroprotective. However, despite potential beneficial effects, their use is also burdened with risks of fatal reactions such as anaphylaxis. The role of MRGPRX2 in these reactions is a subject of debate. This review explores the literature on xenobiotic compounds from herbal medicines that have been shown to act as MRGPRX2 ligands, and their potential clinical significance.

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“…A preparation derived from traditional Chinese medicine, Mailuoning injection purports to have the following benefits: promoting circulation, resolving blood stasis, nourishing ‘yin’ (according to the theory of traditional Chinese medicine), and reducing heat. It contains elements including honeysuckle, Radix Scrophulariae, and Dendrobium 7,8 . It is presently utilized in the management of cardiovascular disorders and is hypothesized to enhance cerebral microcirculation, regulate hemorheology, and demonstrate antithrombotic properties.…”

Section: Introductionmentioning

confidence: 99%

“…It contains elements including honeysuckle, Radix Scrophulariae, and Dendrobium. 7 , 8 It is presently utilized in the management of cardiovascular disorders and is hypothesized to enhance cerebral microcirculation, regulate hemorheology, and demonstrate antithrombotic properties. Initial investigations suggest that Mailuoning may have the capacity to effectively manage thrombophlebitis.…”

Section: Introductionmentioning

confidence: 99%

Assessing Mailuoning injection in wound healing and thrombophlebitis management: A rat model study

Xiao,

Xie,

Liu

et al. 2023

International Wound Journal

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Thrombophlebitis is the inflammatory condition characterized by obstruction of one or more vessels, commonly in the legs, due to the formation of blood clots. It has been reported that traditional Chinese medicine, including Mailuoning injection, is advantageous for treating inflammatory and blood disorders. This research assessed the therapeutic efficacy of Mailuoning injection in the treatment of thrombophlebitis in rodents, as well as investigated its impact on fibrinolysis, inflammation, and coagulation. An experimental setup for thrombophlebitis was established in rodents via modified ligation technique. Five groups comprised the animals: sham operation group, model group, and three Mailuoning treatment groups (low, medium, and high dosages). The pain response, edema, coagulation parameters (PT, APTT, TT, FIB), serum inflammatory markers (IL‐6, TNF‐α, CRP), and expression levels of endothelial markers (ICAM‐1, VCAM‐1, NF‐κB) were evaluated. Blood flow and vascular function were further assessed by measuring hemorheological parameters and the concentrations of TXB2, ET, and 6‐k‐PGF1α. In contrast to the sham group, model group demonstrated statistically significant increases in endothelial expression levels, coagulation latencies, and inflammatory markers (p < 0.05). The administration of mailing, specifically at high and medium dosages, resulted in a substantial reduction in inflammatory markers, enhancement of coagulation parameters, suppression of ICAM‐1 and VCAM‐1 expression, and restoration of hemorheological measurements to baseline (p < 0.05). Significantly higher concentrations of 6‐k‐PGF1α and lower levels of TXB2 and ET were observed in high‐dose group, suggesting that pro‐ and anti‐thrombotic factors were restored to equilibrium. Utilization of Mailuoning injection in rat model of thrombophlebitis exhibited significant therapeutic impact. This effect was manifested through pain alleviation, diminished inflammation, enhanced blood viscosity and facilitation of fibrinolysis. The study indicated that Mailuoning injection may serve as a viable therapeutic option for thrombophlebitis, potentially aiding in the improvement of wound healing by virtue of its anti‐inflammatory and blood flow‐enhancing characteristics.

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Chinese herbal injection for cardio-cerebrovascular disease: Overview and challenges

Cited by 14 publications

References 148 publications

Efficacy and safety of Shen Gui capsules for chronic heart failure: a systematic review and meta-analysis

Efficacy and safety of Shen Gui capsules for chronic heart failure: a systematic review and meta-analysis

Modulation of the Mas-Related G Protein-Coupled Receptor X2 (MRGPRX2) by Xenobiotic Compounds and Its Relevance to Human Diseases

Assessing Mailuoning injection in wound healing and thrombophlebitis management: A rat model study

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