Chinese herbal medicine for cancer-related fatigue: A systematic review of randomized clinical trials

Su, Chunxiang; Wang, Liqiong; Grant, Suzanne; Liu, Jianping

doi:10.1016/j.ctim.2014.04.007

Cited by 42 publications

(29 citation statements)

References 35 publications

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“…It significantly interferes with patients' daily activities and decreases their quality of life (12,94). However, it remains under-recognized and under-treated, partly because of limited understanding of its pathophysiology and lack of effective treatments.…”

Section: Fatiguementioning

confidence: 99%

“…Several Chinese herbal medicines may have beneficial effects on cancer-related fatigue and quality of life for cancer patients. To assess the effectiveness and safety of Chinese herbal medicine for the treatment of cancer-related fatigue, a meta-analysis enrolled a total of 10 randomized controlled trials and 751 patients with various cancers such as liver, lung, and breast cancer were identified and analyzed (94). The results showed that some TCMs such as TJ-41 used alone or in combination with chemotherapy or supportive care showed significant relief in cancer-related fatigue and improved quality of life compared to chemotherapy or supportive care based on single trials.…”

Section: Fatiguementioning

confidence: 99%

See 1 more Smart Citation

The advantages of using traditional Chinese medicine as an adjunctive therapy in the whole course of cancer treatment instead of only terminal stage of cancer

Zhao

Zhou

et al. 2015

BST

381

268

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Section: Fatiguementioning

confidence: 99%

Section: Fatiguementioning

confidence: 99%

The advantages of using traditional Chinese medicine as an adjunctive therapy in the whole course of cancer treatment instead of only terminal stage of cancer

Zhao

Zhou

et al. 2015

BST

381

268

View full text Add to dashboard Cite

“…These effects are thought to be mainly due to the methylxanthine present in the plant's seeds. Chinese herbal medicine and acupuncture have not been thoroughly studied, but trends toward effective and safe use have been seen in randomized clinical trials to treat CRF [63]. Patients using herbal treatments should exercise caution because of possible profound drug interactions.…”

Section: Interventionsmentioning

confidence: 99%

Cancer-related and treatment-related fatigue

Wang

Woodruff

2015

Gynecologic Oncology

140

105

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Fatigue is a distressing and persistent symptom for patients with gynecological cancer and for survivors. Debilitating cancer-related fatigue (CRF) is produced by both the disease and its treatment. Although awareness and study of CRF have grown in recent years, consistent assessment has not been a priority in routine medical practice. The pathophysiological mechanisms that induce CRF remain unclear, and effective pharmacological interventions have yet to be established. Based on the literature and our own research results, this review focuses on recent progress toward understanding the nature and causes of CRF and on several promising treatment modalities. Given the prevalence and severity of CRF in the gynecological cancer patient population, establishing standardized fatigue measurement and management methods in routine clinical oncology care is of utmost importance. Whether CRF has an underlying inflammatory cause is still hypothetical, however, and no mechanism-driven symptom intervention is currently in clinical use, even though the development of such interventions would provide patients with greater symptom control. Advancing translational and clinical fatigue research will require anatomical pathway studies and well-designed clinical investigations that focus on the development of mechanism-driven interventions based on physiological–behavioral fatigue research, implementation of guidelines for experimental designs, and discovery of biomarkers identifying individuals at high risk for CRF. Validated patient-reported outcomes measures are an essential component of such clinical studies. Because numerous subscales, unidimensional measures, and multidimensional measures exist, clinicians and researchers should consider individual circumstances, good clinical practice, and research goals as guides for choosing the most appropriate fatigue measurement tool. Additionally, education about CRF should be made available to all patients and their caregivers, as accurate and age-appropriate information about conditions like CRF can alleviate much of the stress and anxiety brought on by poor communication about this distressing condition.

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“…A systematic review of randomized clinical trials involving 10 trials and 751 participants was conducted to analyze the effect of Chinese herbal medicine for cancerrelated fatigue (114). The findings showed that Chinese herbal medicine plus chemotherapy or supportive care was superior to chemotherapy or supportive care in improving quality of life including relieving cancerrelated fatigue and anxiety.…”

Section: Fatiguementioning

confidence: 99%

An update on Chinese herbal medicines as adjuvant treatment of anticancer therapeutics

Wang

Cui

et al. 2018

BST

192

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Chinese herbal medicine for cancer-related fatigue: A systematic review of randomized clinical trials

Cited by 42 publications

References 35 publications

The advantages of using traditional Chinese medicine as an adjunctive therapy in the whole course of cancer treatment instead of only terminal stage of cancer

The advantages of using traditional Chinese medicine as an adjunctive therapy in the whole course of cancer treatment instead of only terminal stage of cancer

Cancer-related and treatment-related fatigue

An update on Chinese herbal medicines as adjuvant treatment of anticancer therapeutics

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