Chinese herbal medicine for patients with atrial fibrillation

Cai, Xiaoli; Wang, Yuanping; Li, Ziqing; Wang, Dawei; Yan, Xiaofeng

doi:10.1097/md.0000000000009228

Cited by 5 publications

(5 citation statements)

References 22 publications

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“…In addition, TCM showed a lower risk of adverse events than did standard western treatments (Chen et al, 2016). Studies have shown that TCM is effective in treating atrial fibrillation and has relatively few side effects, but the mechanism of action is still unclear (Wang et al, 2011; Liu et al, 2014; Cai et al, 2017). However, respective RCTs of TCM are limited, because there has been no English meta-analysis of TCM treatment for some diseases.…”

Section: Conclusion and Prospectsmentioning

confidence: 99%

Systems Pharmacology for Investigation of the Mechanisms of Action of Traditional Chinese Medicine in Drug Discovery

et al. 2019

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As a traditional medical intervention in Asia and a complementary and alternative medicine in western countries, traditional Chinese medicine (TCM) has attracted global attention in the life science field. TCM provides extensive natural resources for medicinal compounds, and these resources are generally regarded as effective and safe for use in drug discovery. However, owing to the complexity of compounds and their related multiple targets of TCM, it remains difficult to dissect the mechanisms of action of herbal medicines at a holistic level. To solve the issue, in the review, we proposed a novel approach of systems pharmacology to identify the bioactive compounds, predict their related targets, and illustrate the molecular mechanisms of action of TCM. With a predominant focus on the mechanisms of actions of TCM, we also highlighted the application of the systems pharmacology approach for the prediction of drug combination and dynamic analysis, the synergistic effects of TCMs, formula dissection, and theory analysis. In summary, the systems pharmacology method contributes to understand the complex interactions among biological systems, drugs, and complex diseases from a network perspective. Consequently, systems pharmacology provides a novel approach to promote drug discovery in a precise manner and a systems level, thus facilitating the modernization of TCM.

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Section: Conclusion and Prospectsmentioning

confidence: 99%

Systems Pharmacology for Investigation of the Mechanisms of Action of Traditional Chinese Medicine in Drug Discovery

et al. 2019

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“…TCM produces satisfactory effects in AF treatment, with few toxic and side effects. AF patients benefit much in improving clinical signs and symptoms as well as quality of life [ 16 , 17 ].…”

Section: Introductionmentioning

confidence: 99%

Network Pharmacology and Pharmacological Mechanism of CV-3 in Atrial Fibrillation

Wang

Zeng

et al. 2022

Evidence-Based Complementary and Alternative Medicine

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The high fatality and disability rate of atrial fibrillation (AF) strongly promote the development of pathogenesis and treatment of AF that is of great value. The present research attempted to clarify potential mechanisms of Mujiangzi oil (CV-3) in treating AF by constructing an AF cardiomyocytes model and using a network pharmacology approach. The experiment was divided into 4 groups: control, an AF model, AF + CV-3-treated, and the AF + verapamil group. Flow cytometry and the MTT assay were employed to detect cell apoptosis and cell viability, respectively. The main active components of CV-3 and predicted targets were obtained firstly, and molecular docking was performed. In the AF model, the cell apoptosis was aggravated, but inhibited in the CV-3-treated group. In addition, the cell viability was recovered after CV-3 treatment compared with the model group. Five potential active compounds of CV-3 were collected, including effective ingredients N-decanoic acid, spathulenol, copaene, β-panasinsene, and eucalyptol. Among them, N-decanoic acid and spathulenol was demonstrated to bind to PTGS2 with binding energy of −4.08 and −7.09 kcal/mol, respectively, and hydrogen bonds interaction were found. The present study indicated that CV-3 could alleviate AF cardiomyocytes apoptosis and improve cardiomyocytes viability, and N-decanoic acid and spathulenol may be the key components of CV-3 in treatment of AF by regulating PTGS2. This study provided the possible target PTGS2 and the understanding of molecular mechanisms of CV-3 in treating AF.

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“…[ 9 ] The results of many clinical randomized controlled trials show that supplementary and alternative drugs have similar antiarrhythmic effects with AAD, and the incidence of adverse events is low. [ 10 – 11 ] Among them, Wenxin granule (WXG), which is composed of 5 kinds of Chinese herbal medicines, including Ginseng (ren shen), Polygonatum (huang jing), pseudo-ginseng (san qi), lamber (hu po), and Nardostachys Chinensis (gan song), is commonly used in AF treatment practice. The formula of WXG is based on the traditional Chinese medicine theories of tonifying Qi, nourishing Yin, promoting blood circulation to remove the obstructions to calm the mind.…”

Section: Introductionmentioning

confidence: 99%

Comparative efficacy and safety of wenxin granule combined with antiarrhythmic drugs for atrial fibrillation

et al. 2021

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Background: The combination of Chinese patent medicine Wenxin Granules (WXG) and antiarrhythmic drugs has been widely used in the treatment of atrial fibrillation (AF), but the results are controversial. This study will conduct a network meta-analysis (NMA) based on data from randomized controlled trials to evaluate the efficacy and safety of WXG combined with ADDs (amiodarone, metoprolol, propafenone, bisoprolol, or other antiarrhythmic drugs) in the treatment of AF, which will perform comparisons or rankings of efficacy among the currently available therapeutic schemes in order to provide evidence to determine the optimal threshold and treatment regimen to AF patients. Methods and analysis: A comprehensive systematic literature search will be conducted in Cochrane Library, PubMed, Web of Science, EMBASE, Chinese Biomedical Literature Database (SinoMed), Chinese National Knowledge Infrastructure (CNKI), and WanFang database for randomized controlled trials about the WXG with ADDs. The NMA will be conducted following the PRISMA-NMA guidelines. Statistical analyses will be conducted by using Stata software (version 14.0) and RevMan software (version 5.3). Results: The results of this NMA will provide a high-quality evidence for the efficacy of WXG combined with ADDs in the treatment of AF, and a ranking of the therapeutic classes will also be presented. Conclusion: The protocol will provide updated evidence for the application of WXG for AF.

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Chinese herbal medicine for patients with atrial fibrillation

Abstract: Supplemental Digital Content is available in the text

Cited by 5 publications

References 22 publications

Systems Pharmacology for Investigation of the Mechanisms of Action of Traditional Chinese Medicine in Drug Discovery

Systems Pharmacology for Investigation of the Mechanisms of Action of Traditional Chinese Medicine in Drug Discovery

Network Pharmacology and Pharmacological Mechanism of CV-3 in Atrial Fibrillation

Comparative efficacy and safety of wenxin granule combined with antiarrhythmic drugs for atrial fibrillation

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