Chinese herbal medicine for psoriasis

Zhang, Jie; Yu, Qianying; Peng, Li; Lin, Wenxia; Qin, Yuesi; He, Ying; Guo, Jing; Xiao, Min; Chen, Mingling

doi:10.1097/md.0000000000022400

Cited by 7 publications

(6 citation statements)

References 19 publications

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“…The overview protocol was registered with Open Science Framework (registration No. : DOI 10.17605/OSF.IO/VC654) and published in Medicine ( Zhang et al, 2020 ).…”

Section: Methodsmentioning

confidence: 99%

Benefits and Safety of Chinese Herbal Medicine in Treating Psoriasis: An Overview of Systematic Reviews

Zhang

Peng

et al. 2021

Front. Pharmacol.

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Background: In recent years, systematic reviews/meta-analyses (SRs/MAs) of Chinese herbal medicine (CHM) for psoriasis have continuously emerged. Their methods and evidence quality, however, are yet to be evaluated, and whether their conclusions can provide clinicians with reliable evidence is still debatable.Objectives: This overview aims to evaluate the methodological quality, risk of bias, and reporting quality of relevant SRs/MAs, as well as the current evidence of CHM for treating psoriasis.Methods: We searched nine electronic databases from their respective time of establishment to January 20, 2021, as well as the reference lists of the included SRs/MAs, protocol registries, and gray literature. Two reviewers independently used the following: A Measurement Tool to Assess Systematic Reviews (AMSTAR) 2, Risk of Bias in Systematic Reviews (ROBIS), the Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA), and Grades of Recommendations, Assessment, Development and Evaluation (GRADE) to evaluate the methodological quality, risk of bias, reporting quality, and evidence quality of the included SRs/MAs.Results: This review included 14 SRs/MAs involving 45 outcomes, of which 12 (85.71%) SRs/MAs had a very low quality evaluated by AMSTAR 2 and 7 (50.00%) SRs/MAs had a high risk of bias assessed by ROBIS. The protocol and registration and funding statements were the major reporting flaws according to the PRISMA checklist. The evaluation with the GRADE system demonstrated no outcome of high-quality evidence, and inconsistent efficacy evaluations were found in this overview. Only 15 (33.33%) outcomes were moderate-quality evidence, supporting the claim that CHM plus Western medicine (WM) was superior to WM. Generally low quality of evidence showed no difference in the incidence of adverse events between the combined therapy and WM. However, the conclusion that CHM was superior to WM cannot be drawn due to the inconsistent results.Conclusion: Despite that CHM has the potential benefit and safety in the adjuvant treatment of psoriasis, the conclusion should be treated with caution because of the generally low quality of methodology and evidence. In the future, high-quality randomized controlled trials (RCTs) should be carried out, and the quality of relevant SRs should also be improved to promote their clinical application.

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“…The overview protocol was registered with Open Science Framework (registration No. : DOI 10.17605/OSF.IO/VC654) and published in Medicine ( Zhang et al, 2020 ).…”

Section: Methodsmentioning

confidence: 99%

Benefits and Safety of Chinese Herbal Medicine in Treating Psoriasis: An Overview of Systematic Reviews

Zhang

Peng

et al. 2021

Front. Pharmacol.

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“…[ 51 ] While SY and THF are commonly used conventional treatments for progressive psoriasis, STT has shown significant clinical efficacy in psoriasis treatment. [ 8 , 9 , 52 , 53 ] However, the core targets and active ingredients of STT remain largely unknown, posing a challenge to its further development and clinical application. Therefore, this study employs network pharmacology and molecular docking techniques to elucidate the mechanisms underlying the therapeutic effects of STT in psoriasis.…”

Section: Discussionmentioning

confidence: 99%

“…Traditional Chinese medicine (TCM) provides advantages including prolonged remission, stable conditions, reduced recurrence, and lower toxicity and side effects. [6][7][8] Nonetheless, the precise mechanisms by which TCM combats psoriasis have yet to be fully elucidated, limiting its widespread adoption.…”

Section: Introductionmentioning

confidence: 99%

A network pharmacology and molecular docking investigation on the mechanisms of Shanyaotianhua decoction (STT) as a therapy for psoriasis

Yue,

Feng,

Gao

2023

Medicine

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Psoriasis is an immune-mediated inflammatory skin disease with a complex etiology involving environmental and genetic factors. Psoriasis patients often require long-term treatment. Shanyaotianua decoction (STT), a typical traditional Chinese medicine prescription, positively affects psoriasis, although its molecular targets remain unknown. To elucidate its molecular mechanisms, a combination of network pharmacology, bioinformatics analysis, and drug similarity comparisons were employed. Participants were separated into 3 groups: non-lesional (NL), lesions after medication (LM), and psoriasis lesion groups (LS). Based on the Gene Ontology/kyoto encyclopedia of genes and genomes enrichment analyses, the key targets were mainly enriched for biological processes (immuno-inflammatory responses, leukocyte differentiation, lipid metabolic disorders, and viral infection) with the relevant pathways (Janus kinase/signal transducers and activators of transcription and adipocytokine signaling and T-helper 17 cell differentiation), thus identifying the possible action mechanism of STT against psoriasis. Target prediction for 18 STT compounds that matched the screening criteria was performed. Then, the STT compounds were intersected with the differentially expressed genes of the psoriatic process, and 5 proteins were potential targets for STT. Based on the open-source toolkit RDKit and DrugBank database, and through molecular docking and drug similarity comparisons, spinasterol, diosgenin, and 24-Methylcholest-5-enyl-3belta-O-glucopyranoside_qt may be potential drugs for psoriasis.

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“…6 Chinese herbal medicine has been increasingly revealed to exhibit effectiveness and safety as an adjuvant treatment of psoriasis. 7,8 Scutellaria baicalensis Georgi is a common heat-clearing medicine in traditional Chinese medicine, the preparation from the root of which is widely applied to treat diarrhea, dysentery, hypertension, hemorrhaging, insomnia, inflammation, and respiratory infections in clinical settings. 9 However, as a naturally occurring flavonoid compound that stems from the root extract of S. baicalensis Georgi, Wogonin has not been used in Western medicine in the form of a pure chemical.…”

Section: Introductionmentioning

confidence: 99%

Wogonin ameliorates the proliferation, inflammatory response, and pyroptosis in keratinocytes via NOD‐like receptor family pyrin domain containing 3/Caspase‐1/Gasdermin‐D pathway

Ma,

Ji,

Sun

et al. 2024

Immunity Inflam & Disease

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BackgroundPsoriasis refers to a highly prevalent and immunologically mediated dermatosis with considerable deterioration in life quality. Wogonin, a sort of flavonoid, has been mentioned to elicit protective activities in skin diseases. However, whether Wogonin is implicated in the treatment of psoriasis and its specific mechanisms are not fully understood.AimThe present work attempted to elaborate the role of Wogonin during the process of psoriasis and to concentrate on the associated action mechanism.MethodsCell counting kit‐8 (CCK‐8) method was initially applied to assay the viability of human keratinocyte HaCaT cells treated by varying concentrations of Wogonin. To mimic psoriasis in vitro, HaCaT cells were exposed to M5 cytokines. CCK‐8 and 5‐Ethynyl‐2′‐deoxyuridine assays were adopted for the measurement of cell proliferation. Inflammatory levels were examined with enzyme‐linked immunosorbent assay. Immunofluorescence staining tested nucleotide‐binding oligomerization domain (NOD)‐like receptor family pyrin domain containing 3 (NLRP3) and Caspase‐1 expressions. Western blot examined the protein expressions of proliferation‐, inflammation‐, pyroptosis‐associated factors, and NLRP3.ResultsWogonin treatment antagonized the proliferation, inflammatory response, and NLRP3/caspase‐1/Gasdermin‐D (GSDMD)‐mediated pyroptosis in M5‐challenged HaCaT cells. Besides, NLRP3 elevation partially abrogated the effects of Wogonin on M5‐induced proliferation, inflammatory response, and NLRP3/caspase‐1/GSDMD‐mediated pyroptosis in HaCaT cells.ConclusionIn a word, Wogonin might exert anti‐proliferation, anti‐inflammatory and anti‐pyroptosis activities in M5‐induced cell model of psoriasis and the blockade of NLRP3/Caspase‐1/GSDMD pathway might be recognized as a potential mechanism underlying the protective mechanism of Wogonin in psoriasis, suggesting Wogonin as a prospective anti‐psoriasis drug.

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Chinese herbal medicine for psoriasis

Cited by 7 publications

References 19 publications

Benefits and Safety of Chinese Herbal Medicine in Treating Psoriasis: An Overview of Systematic Reviews

Benefits and Safety of Chinese Herbal Medicine in Treating Psoriasis: An Overview of Systematic Reviews

A network pharmacology and molecular docking investigation on the mechanisms of Shanyaotianhua decoction (STT) as a therapy for psoriasis

Wogonin ameliorates the proliferation, inflammatory response, and pyroptosis in keratinocytes via NOD‐like receptor family pyrin domain containing 3/Caspase‐1/Gasdermin‐D pathway

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