Chinese Herbal Medicine in Ameliorating Diabetic Kidney Disease via Activating Autophagy

Wang, Yuyang; Zhao, Hailing; Wang, Qian; Zhou, Xuefeng; Lu, Xiaoguang; Liu, Tongtong; Zhan, Yongli; Li, Ping

doi:10.1155/2019/9030893

Cited by 26 publications

(17 citation statements)

References 68 publications

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“…TCM holds the unique advantages of multi-target and multi-pathway regulation in the treatment of complex diseases with high e cacy, low toxicity, and few side effects [4][5][6][7][8][9] . Previous research illustrated that RJSJ is safe and well tolerated, and it does not induce body weight loss, immune dysregulation, or myelosuppression in mice 13 .…”

Section: Discussionmentioning

confidence: 99%

“…The characteristics and advantages of traditional Chinese medicine (TCM) in the prevention and treatment of complex diseases, such as cancers, cardiovascular diseases, infectious diseases, metabolic diseases, and neurodegenerative diseases, have attracted global attention, and such treatments have been illustrated to ameliorate symptoms, improve patient quality of life, and prolong survival [4][5][6][7][8][9] . In 2018, the WHO International Classi cation of Diseases listed traditional medicines, including TCM, in its classi cation system for the rst time 10 .…”

Section: Introductionmentioning

confidence: 99%

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Ruanjian Sanjie Decoction Induces Apoptosis in Triple-negative Breast Cancer Cells by Downregulating cIAP1/2 and XIAP

Zhao¹,

Wang²,

Jia³

et al. 2020

Preprint

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Background: Traditional Chinese medicine (TCM) comprises a unique theoretical system developed over thousands of years. The previous study reported that Ruanjian Sanjie (RJSJ) exerts anti-tumor effects by inducing cell apoptosis. However, the mechanism is not clear. Methods: In this study, we investigated the possible mechanism by the strategy of combining network pharmacology analysis with experiment (in vitro and in vivo). First, four kinds of breast cancer cell lines were used to conduct proliferation, apoptosis and cell cycle analysis. Secondly, to study pathophysiological processes of breast cancer at the molecular network level, we for the first time constructed an “integrated apoptosis module network of breast cancer” by assembling the regulatory relationships of canonical apoptosis signaling pathways. Through the strategy of combining network analysis and experiments, we analyzed the main mechanism of RJSJ in breast cancer and screened out the core genes. We further studied the inhibitory effect of RJSJ combined with carboplatin (CBP) in vivo. Finally, the synergistic effect of RJSJ and CBP were analyzed and the potential active components in RJSJ were predicted.Results: This study demonstrated that RJSJ could significantly inhibit breast cancer cell proliferation and induce apoptosis in a concentration-dependent manner. The primary mechanism of RJSJ in the treatment of breast cancer was pro-apoptotic. The core apoptosis genes regulated by RJSJ were cIAP1/2 and XIAP. We also found that RJSJ in combination with CBP tended to synergistically induce apoptosis, which might mainly be achieved through the regulation of multiple targets and pathways. Alexandrin (BX05, XKC02, SCG01), baicalin (BX22), guanosine (BX32), arjunglucoside I (XKC10) etc. were predicted as potential active components.Conclusions: These findings provide the rationale for exploring the therapeutic effects of RJSJ against breast cancer and providing a bridge for the combined use of Chinese and Western medicine.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Ruanjian Sanjie Decoction Induces Apoptosis in Triple-negative Breast Cancer Cells by Downregulating cIAP1/2 and XIAP

Zhao¹,

Wang²,

Jia³

et al. 2020

Preprint

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“…At present, a number of plant natural products have either been clinically used to treat a variety of human diseases, or have shown particularly interesting biological activities that are worth further exploration ( Li and Weng, 2017 ), such as artemisinin from artemisia annua , which has great anti-malaria effect and won the Nobel prize in 2015. Recently, some studies have found that herbal medicines play different pharmacological roles in renal diseases including ADPKD ( Wang et al, 2019 ). Several natural herbal medicines have been reported to restrain cystogenesis and improve renal function in animal models of ADPKD ( Yuajit and Chatsudthipong, 2016 ).…”

Section: Introductionmentioning

confidence: 99%

Applications of Herbal Medicine to Treat Autosomal Dominant Polycystic Kidney Disease

2021

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Autosomal dominant polycystic kidney disease (ADPKD) is a common hereditary kidney disease, which is featured by progressively enlarged bilateral fluid-filled cysts. Enlarging cysts destroy the structure of nephrons, ultimately resulting in the loss of renal function. Eventually, ADPKD develops into end-stage renal disease (ESRD). Currently, there is no effective drug therapy that can be safely used clinically. Patients progressed into ESRD usually require hemodialysis and kidney transplant, which is a heavy burden on both patients and society. Therefore, looking for effective therapeutic drugs is important for treating ADPKD. In previous studies, herbal medicines showed their great effects in multiple diseases, such as cancer, diabetes and mental disorders, which also might play a role in ADPKD treatment. Currently, several studies have reported that the compounds from herbal medicines, such as triptolide, curcumin, ginkolide B, steviol, G. lucidum triterpenoids, Celastrol, saikosaponin-d, Sparganum stoloniferum Buch.-Ham and Cordyceps sinensis, contribute to the inhibition of the development of renal cysts and the progression of ADPKD, which function by similar or different mechanisms. These studies suggest that herbal medicines could be a promising type of drugs and can provide new inspiration for clinical therapeutic strategy for ADPKD. This review summarizes the pharmacological effects of the herbal medicines on ADPKD progression and their underlying mechanisms in both in vivo and in vitro ADPKD models.

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“…Statistics from the International Diabetes Federation show that deaths due to diabetic nephropathy account for approximately 9% of the total deaths. Hence, there is a pressing need to develop effective treatments for diabetic nephropathy patients (5). At present, the main measures used by Western medicine to treat diabetic nephropathy are to control blood sugar, blood lipids, improve renal function, adjust diet, and exercise moderately (6,7).…”

Section: Introductionmentioning

confidence: 99%

Therapeutic effects of Yiqi Huoxue prescription on diabetic nephropathy: a meta-analysis and systematic review

Yuan¹,

Gu²,

Feng³

et al. 2021

Ann Palliat Med

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Background: Traditional Chinese Medicine (TCM) has demonstrated excellent effects in treating diabetic nephropathy, and Yiqi Huoxue Prescription has been widely used clinically. In the study, its effects on the kidney function and blood glucose of patients were explored.Methods: Chinese and English databases including PubMed, Medline, Embase, and Web of Sciences were used to retrieve articles comparing the treatment of diabetic nephropathy using Yiqi Huoxue prescription on the basis of conventional Western medicine treatment (experimental group) and conventional Western medicine treatment alone (control group) published from January 2000 to December 2020. The risk of bias assessment tool of the Cochrane System Review Manual 5.2.2 and the Jadad scale were used to evaluate the quality of the included literature. The outcome indexes were extracted, and the Review Manager 5.3 software was used for meta-analysis.Results: A total of 13 articles that satisfied the inclusion/exclusion criteria were included in this study. After treatment, compared to the control group, the experimental group exhibited lower urine microalbumin excretion rate (UAER) [mean difference (MD) =−33.94, 95% confidence interval (CI), −42.60 to −25.28, P<0.00001], serum creatinine (SCr) (MD =−7.43, 95% CI, −11.50 to −3.36, P=0.0004), blood urea nitrogen (BUN) (SMD =−1.23, 95% CI, −2.49 to 0.03, P=0.04), blood glucose-related indexes [fasting blood glucose (FBG)] (MD =−0.43, 95% CI, −0.87 to 0.01, P=0.03), glycosylated hemoglobin (HbA1c) (MD =−0.38, 95% CI, −0.68 to −0.08, P=0.01), blood lipid-related indexes [triglycerides (TG)] (MD =−0.44, 95% CI, −0.76 to −0.13, P=0.006), and serum total cholesterol (TC) (MD =−0.37, 95% CI, −0.57 to −0.18, P=0.0002). Furthermore, the experimental group also showed higher effectiveness rate (odds ratio =3.81, 95% CI, 2.71 to 5.35, P<0.00001) after treatment. Discussion: The included literature had low bias risk. Yiqi Huoxue prescription on the basis of conventional Western medicine can significantly improve the renal function and reduce the levels of blood glucose and blood lipids of patients with diabetic nephropathy.

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Chinese Herbal Medicine in Ameliorating Diabetic Kidney Disease via Activating Autophagy

Cited by 26 publications

References 68 publications

Ruanjian Sanjie Decoction Induces Apoptosis in Triple-negative Breast Cancer Cells by Downregulating cIAP1/2 and XIAP

Ruanjian Sanjie Decoction Induces Apoptosis in Triple-negative Breast Cancer Cells by Downregulating cIAP1/2 and XIAP

Applications of Herbal Medicine to Treat Autosomal Dominant Polycystic Kidney Disease

Therapeutic effects of Yiqi Huoxue prescription on diabetic nephropathy: a meta-analysis and systematic review

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