Chinese herbal medicine TangBi Formula treatment of patients with type 2 diabetic distal symmetric polyneuropathy disease: study protocol for a randomized controlled trial

Jin, De; Huang, Wenjing; Meng, Xiang; Fan, Yang; Zheng, Yujiao; Bao, Qi; Zhang, Meizhen; Yang, Yaran; Ni, Qing; Lian, Fengmei; Tong, Xiaolin

doi:10.1186/s13063-017-2345-1

Cited by 7 publications

(5 citation statements)

References 24 publications

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“…However, their studies did not explicitly mention the MDNS. Jin et al studied the improvement in the MDNS caused by TCM [44]. Radix Puerariae or Poria cocos is highly related to decreased FPG and HbA1c levels when combined with Radix Rehmanniae and Radix Ophiopogonis or Astragalus membranaceus.…”

Section: Discussionmentioning

confidence: 99%

Clinical Features and Rules of Chinese Herbal Medicine in Diabetic Peripheral Neuropathy Patients

Zhao

Xin

et al. 2020

Evidence-Based Complementary and Alternative Medicine

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Objective. To analyse the clinical features of diabetic peripheral neuropathy (DPN) and employ data mining technology to explore the rules of Chinese herbal medicine (CHM) therapy. Methods. The clinical data of 216 patients with DPN and qi-yin deficiency syndrome were obtained, and the clinical features of the patients were assessed by cluster analysis. Relevant information was entered into the clinical diagnosis and treatment collection system, and data mining techniques were used to analyse the drug frequency, core CHM, CHM pair, and so on. Results. In this study, glycated haemoglobin (HbA1c) and homocysteine (HCY) were closely related to the pathogenesis of DPN. Overall, 162 patients had typical DPN syndrome characteristics, and we analysed 216 prescriptions, including 182 CHM. The frequencies of prescription of Astragalus membranaceus, Ligusticum wallichii, Poria cocos, and Radix Rehmanniae were greater than 45%. A Bayesian network analysis diagram showed that the 9 most common core CHM included Astragalus membranaceus, Ligusticum wallichii, Poria cocos, atractylodes rhizome, and Salvia miltiorrhiza Bge. According to the association rules of CHM, Radix Ophiopogon is used for Codonopsis pilosula; Astragalus membranaceus and atractylodes rhizome for Rehmannia are also frequently used. Astragalus membranaceus and Cinnamomi Ramulus or Ligusticum wallichii and Moutan bark were highly related to a decreased Michigan Diabetic Neuropathy Score. Conclusion. HbA1c and HCY are related risk factors for DPN. Numbness is a typical syndrome characteristic. Astragalus membranaceus is a monarch CHM and is used most frequently.

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Section: Discussionmentioning

confidence: 99%

Clinical Features and Rules of Chinese Herbal Medicine in Diabetic Peripheral Neuropathy Patients

Zhao

Xin

et al. 2020

Evidence-Based Complementary and Alternative Medicine

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“…However, TCM practitioners often use a combination of multiple herbs or minerals to compose CHM formulas based on TCM principles, instead of a single herb or mineral, an approach that focuses on enhancing clinical efficacy by targeting complex pathogenetic mechanisms. In Tong's outpatient clinic, he applied the principle of nourishing Qi and promoting blood circulation to treat pDPN patients and chose the HGWD regimen including some herbs with the specific function of relieving neuropathic pain [19,32].…”

Section: Discussionmentioning

confidence: 99%

Efficacy of Chinese Herbal Medicine in the Treatment of Moderate-Severe Painful Diabetic Peripheral Neuropathy: A Retrospective Study

Zheng

Fan

Lin

et al. 2019

Journal of Diabetes Research

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Painful diabetic peripheral neuropathy (pDPN) is a debilitating complication of diabetes. The aim of this retrospective study was to investigate the effectiveness of a Chinese herbal medicine regimen—the modified Huangqi Guizhi Wuwu Decoction (HGWD)—in the treatment of moderate-severe pDPN. The primary objective was to estimate the improvement in neuropathic pain severity. The secondary objective was to assess the response of common symptoms to the treatment. The change in patients’ blood glucose level during the whole treatment was also evaluated. By searching through our medical records of all the diabetic patients from January 2006 to January 2012, we identified and enrolled 30 moderate and severe pDPN patients in the study, for whom the treatment of neuropathic pain by regular pharmacotherapies had failed. The modified HGWD treatment was administered orally twice a day for 6 months. The numerical rating scale (NRS) level at month 6 was 2.57±2.30, significantly improved compared with the baseline level of 6.03±1.83 (P<0.05). The amelioration of 3 common symptoms, namely, limb pain, limb numbness, and insomnia, was evident, and the major response of common symptoms at month 6 including limb pain, insomnia, and limb coldness was significantly increased compared with the results at month 3 (P<0.05). Moreover, 2-hour postprandial blood glucose (2hPG) level decreased from 10.77±1.29 mmol/L at baseline to 9.66±0.60 mmol/L at month 6 (P<0.05). No serious adverse events occurred throughout the treatment period. The modified HGWD was effective in the treatment of moderate and severe pDPN and can thus be offered as a new alternative treatment option for pDPN patients who failed to respond to regular pharmaceutical therapies.

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“…TSA is implemented through the TSA 0.9.5.10 beta. 1 The estimation of RIS is based on the following statistical indicators: probability of type I error (α = 0.05), probability of type II error (β = 0.2). For dichotomous data, event rate in control group (Pc = 3%, derived from Meta-analysis data) and relative risk reduction (RRR = 35%).…”

Section: Tsa Analysismentioning

confidence: 99%

“…Painful diabetic neuropathy (PDN) is a prevalent complication of diabetic peripheral neuropathy (DPN), which belongs to the category of paralysis in Chinese medicine and often characterized as a combination of Qi deficiency and blood stasis ( 1 , 2 ). The International Association for the Study of Pain characterizes neuropathic pain as “pain triggered or resulting from a primary lesion or malfunction in the nervous system” ( 3 ).…”

Section: Introductionmentioning

confidence: 99%

Efficacy and safety of acupuncture for painful diabetic neuropathy: a systematic review and meta-analysis

Liu,

Lin,

Huang

et al. 2024

Front. Neurol.

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BackgroundPainful diabetic neuropathy (PDN) is a common chronic neurological complication of diabetes mellitus. Medications are often used to relieve pain, but with significant side effects. Acupuncture is now a component of pragmatic and integrative treatment for PDN. An increasing number of relevant randomized controlled trials have been published in recent years, but a comprehensive meta-analysis has not yet been performed. The aim of this paper is to verify the effectiveness and safety of acupuncture for PDN by meta-analysis and trial sequential analysis (TSA).MethodsAll participants in this study should have had a PDN diagnosis and the trial group was treated with acupuncture. Eight databases, including EMbase, PubMed, Web of science, Cochrane Library, China Biology Medicine disc (CBM), China National Knowledge Infrastructure (CNKI), Wanfang and Chongqing VIP (CQVIP) were retrieved from inception to 5 April 2023. Meta-analysis was conducted utilizing RevMan 5.3 and Stata 15.0. TSA was performed to assess the adequacy of sample size for the outcomes.ResultsA total of 36 studies, comprising 2,739 PDN patients, were included. Among them, 1,393 patients were assigned to the trial group and 1,346 patients were treated in the control group. Outcomes covers the primary indicator Total effective rate (RR = 1.42, 95%CI [1.34, 1.52], p < 0.00001), with 21 studies reported, Pain intensity (SMD = −1.27, 95%CI [−1.58, −0.95], p < 0.00001), with 23 studies reported, and other outcomes, including motor nerve conduction velocity (MCV; MD = 3.58, 95%CI [2.77, 4.38], p < 0.00001), sensory nerve conduction velocity (SCV; MD = 3.62, 95%CI [2.75, 4.49], p < 0.00001), Depression score (SMD = −1.02, 95%CI [1.58, 0.46]), Toronto clinical scoring system (TCSS; MD = −2.41, 95%CI [−3.37, −1.45], p < 0.00001), Quality of life (SMD = 1.06, 95%CI [0.66, 1.46]), traditional Chinese medicine (TCM) syndrome score (MD = −4.99, 95%CI [−6.79, −3.18], p < 0.00001), suggesting that acupuncture have an ameliorating effect on PDN in various respect. Egger’s test revealed publication bias for four outcomes. TSA showed that as for Total effective rate, Pain Intensity, MCV and SCV, the number of included studies was sufficient to support the conclusions.ConclusionAcupuncture demonstrates significant effectiveness in improving PDN outcomes, including Total effective rate, Pain intensity, MCV, SCV, Depression score, TCSS, Quality of life, TCM syndrome score. But the Adverse events rate is no different in trail group and control group. The publication bias presented in Total effective rate, Pain intensity, MCV and SCV can be remedied by Trim and filling method.Systematic review registrationProspero, https://www.crd.york.ac.uk/prospero/display_record.php?RecordID=477295.

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Chinese herbal medicine TangBi Formula treatment of patients with type 2 diabetic distal symmetric polyneuropathy disease: study protocol for a randomized controlled trial

Cited by 7 publications

References 24 publications

Clinical Features and Rules of Chinese Herbal Medicine in Diabetic Peripheral Neuropathy Patients

Clinical Features and Rules of Chinese Herbal Medicine in Diabetic Peripheral Neuropathy Patients

Efficacy of Chinese Herbal Medicine in the Treatment of Moderate-Severe Painful Diabetic Peripheral Neuropathy: A Retrospective Study

Efficacy and safety of acupuncture for painful diabetic neuropathy: a systematic review and meta-analysis

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