Chinese herbal medicines for people with impaired glucose tolerance or impaired fasting blood glucose

Grant, Suzanne; Bensoussan, Alan; Chang, Dennis; Kiat, Hosen; Klupp, Nerida L; Liu, Jianping; Li, Xun

doi:10.1002/14651858.cd006690.pub2

Cited by 30 publications

(22 citation statements)

References 31 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A search of Chinese medicine journals and common texts identified eight distinct diagnostic patterns presented by people with prediabetes [27]. Nine diagnostic patterns were identified:

Spleen deficiency with Damp (or Damp-heat),

Qi and Yin deficiency,

Qi deficiency,

Yin deficiency (with Empty heat or Blood stasis),

Phlegm-Damp Qi and Phlegm stagnation,

Liver Qi stagnation (with Blood stasis),

Yang deficiency,

Blood stasis.

…”

Section: Methodsmentioning

confidence: 99%

Interrater Reliability of Chinese Medicine Diagnosis in People with Prediabetes

Grant

Schnyer

Chang

et al. 2013

Evidence-Based Complementary and Alternative Medicine

Self Cite

View full text Add to dashboard Cite

Background. Achieving reproducibility in research design is challenging when patient cohorts under study are inconsistently defined. Traditional Chinese medicine (TCM) diagnosis is one example where inconsistency between practitioners has been found. We hypothesise that the use of a validated instrument may improve consistency. Biochemical biomarkers may also be used enhance reliability. Methods. Twenty-seven participants with prediabetes were assessed by two TCM practitioners using a validated instrument (TEAMSI-TCM). Inter-rater reliability was summarised using percentage agreement and the kappa coefficient. One-way ANOVA and Tukey's post hoc test were used to test links between TCM diagnosis and biomarkers. Results. The two practitioners agreed on primary diagnosis of 70% of participants. kappa = 0.56 (P < 0.001). The three predominant TCM diagnostic patterns for people with prediabetes were Yin deficiency, Qi and Yin deficiency and Spleen qi deficiency. The Spleen Qi deficiency with Damp cohort had statistically significant higher fasting glucose, higher insulin, higher insulin resistance, higher HbA1c and lower HDL than those with Qi and Yin deficiency. Conclusions. Using the TEAMSI-TCM resulted in moderate interrater reliability between TCM practitioners. This study provides initial evidence of variation in the biomarkers of people with prediabetes according to the different TCM patterns which may suggest a route to further improving interrater reliability.

show abstract

“…A search of Chinese medicine journals and common texts identified eight distinct diagnostic patterns presented by people with prediabetes [27]. Nine diagnostic patterns were identified:

Spleen deficiency with Damp (or Damp-heat),

Qi and Yin deficiency,

Qi deficiency,

Yin deficiency (with Empty heat or Blood stasis),

Phlegm-Damp Qi and Phlegm stagnation,

Liver Qi stagnation (with Blood stasis),

Yang deficiency,

Blood stasis.

…”

Section: Methodsmentioning

confidence: 99%

Interrater Reliability of Chinese Medicine Diagnosis in People with Prediabetes

Grant

Schnyer

Chang

et al. 2013

Evidence-Based Complementary and Alternative Medicine

Self Cite

View full text Add to dashboard Cite

show abstract

“…The reviews (34,68,123) share a common theme, a hint of efficacy clouded by poor methodology and lack of replication. But all reviews were eager to see larger better designed studies carried out.…”

Section: Chinese Herbal Medicinementioning

confidence: 99%

The physiological basis of complementary and alternative medicines for polycystic ovary syndrome

Raja-Khan

Stener-Victorin

et al. 2011

American Journal of Physiology-Endocrinology and Metabolism

View full text Add to dashboard Cite

Raja-Khan N, Stener-Victorin E, Wu X, Legro RS. The physiological basis of complementary and alternative medicines for polycystic ovary syndrome. Am J Physiol Endocrinol Metab 301: E1-E10, 2011. First published April 12, 2011 doi:10.1152/ajpendo.00667.2010.-Polycystic ovary syndrome (PCOS) is a common endocrine disorder that is characterized by chronic hyperandrogenic anovulation leading to symptoms of hirsutism, acne, irregular menses, and infertility. Multiple metabolic and cardiovascular risk factors are associated with PCOS, including insulin resistance, obesity, type 2 diabetes, hypertension, inflammation, and subclinical atherosclerosis. However, current treatments for PCOS are only moderately effective at controlling symptoms and preventing complications. This article describes how the physiological effects of major complementary and alternative medicine (CAM) treatments could reduce the severity of PCOS and its complications. Acupuncture reduces hyperandrogenism and improves menstrual frequency in PCOS. Acupuncture's clinical effects are mediated via activation of somatic afferent nerves innervating the skin and muscle, which, via modulation of the activity in the somatic and autonomic nervous system, may modulate endocrine and metabolic functions in PCOS. Chinese herbal medicines and dietary supplements may also exert beneficial physiological effects in PCOS, but there is minimal evidence that these CAM treatments are safe and effective. Mindfulness has not been investigated in PCOS, but it has been shown to reduce psychological distress and exert positive effects on the central and autonomic nervous systems, hypothalamic-pituitary-adrenal axis, and immune system, leading to reductions in blood pressure, glucose, and inflammation. In conclusion, CAM treatments may have beneficial endocrine, cardiometabolic, and reproductive effects in PCOS. However, most studies of CAM treatments for PCOS are small, nonrandomized, or uncontrolled. Future well-designed studies are needed to further evaluate the safety, effectiveness, and mechanisms of CAM treatments for PCOS. acupuncture; mindfulness meditation; herbs; dietary supplements; traditional Chinese medicine POLYCYSTIC OVARY SYNDROME (PCOS), a common endocrine disorder that affects 5-10% of reproductive-age women, is characterized by chronic hyperandrogenic anovulation leading to symptoms of hirsutism, acne, irregular menses, and infertility (86). The exact etiology of PCOS remains unclear, but it is believed to result from complex interactions between genetic, behavioral, and environmental factors. Multiple metabolic and cardiovascular risk factors are associated with PCOS, including insulin resistance (IR), obesity, type 2 diabetes (DM-2), hypertension, dyslipidemia, inflammation, and subclinical cardiovascular disease (32,62,63,87,107). Anxiety, depression, and reduced quality of life are also common in PCOS (5,19,45,107).Current treatments for PCOS are only moderately effective at controlling symptoms and preventing complications. In fact, when 648 women w...

show abstract

“…Such model assessments can reveal the effects of plant-derived secondary metabolites on specific tissue functions in a genetic population. It cannot be ignored that a very high number of plant extracts in controlled laboratory studies seem to exert beneficial effects on inflammatory and metabolic diseases by largely unknown mechanisms [89][90][91][92][93][94][95][96]. Strikingly, it appears that almost any plant extract is somehow effective.…”

Section: Homeostatic-type Model Assessmentswhat Do They Tell Us?mentioning

confidence: 99%

The Metabolic Plant Feedback Hypothesis: How Plant Secondary Metabolites Nonspecifically Impact Human Health

Gertsch

2016

Planta Med

View full text Add to dashboard Cite

Humans can ingest gram amounts of plant secondary metabolites daily through diet. Many of these phytochemicals are bioactive beyond our current understanding because they act through weak negative biological feedback mechanisms, undetectable in vitro. Homeostatic-type assessments shed light on the evolutionary implications of the human diet from plants, giving rise to the metabolic plant feedback hypothesis. The hypothesis states that ancient diets rich in carbohydrates coincide with bulk dietary phytochemicals that act as nonspecific inhibitors of metabolic and inflammatory processes. Consequently, food-derived phytochemicals are likely to be equally effective as herbal medicines for these indications. In addition to the ubiquitous flavonoids, terpenoids, and fatty acids in the diet, the likely impact of chronic chlorophyll ingestion on human health is discussed, and data on its modulation of blood glucose levels are presented. A major deduction of this hypothesis is that starchy diets lacking plant secondary metabolites are associated with multimorbidity (lifestyle diseases) including obesity, type 2 diabetes, and cardiovascular disease. It is proposed that the intake of leafy vegetables, spices, and herbal remedies rich in phytochemicals matches the transition and genetic adaptation to early agriculture, playing a compensatory role in the mismatch of old genes and new diets.

show abstract

Chinese herbal medicines for people with impaired glucose tolerance or impaired fasting blood glucose

Cited by 30 publications

References 31 publications

Interrater Reliability of Chinese Medicine Diagnosis in People with Prediabetes

Interrater Reliability of Chinese Medicine Diagnosis in People with Prediabetes

The physiological basis of complementary and alternative medicines for polycystic ovary syndrome

The Metabolic Plant Feedback Hypothesis: How Plant Secondary Metabolites Nonspecifically Impact Human Health

Contact Info

Product

Resources

About