Chinese herbal products for nasopharyngeal carcinoma: A population-based registry study

Tseng, Shih Ting; Liu, Chun Ting; Wu, Bei; Hung, Yu Chiang; Lin, Chien Hung; Hsu, Chung Y.; Chen, Hsuan Ju; Hu, Wen Long

doi:10.1016/j.eujim.2019.100979

Cited by 4 publications

(3 citation statements)

References 46 publications

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“…Consistent with the findings of earlier research, 14 , 28 this study revealed that Gan-Lu-Yin was the most frequently used Chinese herbal formula for treating HNC. The positive association between Gan-Lu-Yin use and a lower incidence of RIOM may stem from its reported effects that included reducing cell proliferation and the inhibition of inflammatory cytokines through the NF-kB dependent pathway.…”

Section: Discussionsupporting

confidence: 91%

“…25,26 Dysregulation of the α2-AR pathway may contribute to the release of inflammatory cytokines, such as tumor necrosis factor-α (TNF-α), interleukin-1 (IL-1), and IL-6; all of these mediators have been implicated in the development of RIOM. 6,27 Consistent with the findings of earlier research, 14,28 this study revealed that Gan-Lu-Yin was the most frequently used Chinese herbal formula for treating HNC. The positive association between Gan-Lu-Yin use and a lower incidence of RIOM may stem from its reported effects that included reducing cell proliferation and the inhibition of inflammatory cytokines through the NF-kB dependent pathway.…”

Section: Discussionsupporting

confidence: 90%

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Chinese Herbal Medicine to Reduce Radiation-Induced Oral Mucositis in Head and Neck Cancer Patients: Evidence From Population-Based Health Claims

Livneh

Chen

et al. 2021

Integr Cancer Ther

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Background: Subjects with head and neck cancer (HNC) often experience post-treatment side effects, particularly radiation-induced oral mucositis (RIOM). This study aimed to explore the association of Chinese herbal medicine use with the sequent risk of RIOM among them. Methods: This cohort study used a nationwide health insurance database to identify subjects newly diagnosed with HNC, aged 20 to 60 years, who received treatment between 2000 and 2007. Among them, a total of 561 cases received CHM after HNC onset (CHM users); the remaining 2395 cases were non-CHM users. All patients were followed to the end of 2012 to identify any treatment for RIOM as the end point. Cox proportional hazards regression was used to compute the adjusted hazard ratio (aHR) of RIOM by CHM use. Results: During the follow-up period, 183 CHM users and 989 non-CHM users developed RIOM at incidence rates of 40.98 and 57.91 per 1000 person-years, respectively. CHM users had a lower RIOM risk than the non-CHM users (aHR: 0.68; 95% Confidence Interval: 0.58-0.80). The most potent effect was observed in those taking CHM for more than 1 year. Use of Baizhi, Danshen, Shao-Yao-Gan-Cao-Tang, Gan-Lu-Yin, Huangqin, Shu-Jing-Huo-Xue-Tang, and Xin-Yi-Qing-Fei-Tang, was significantly related to a lower risk of RIOM. Conclusion: Findings of this study indicated that adding CHM to conventional clinical care could be helpful in protecting those with HNC against the onset of RIOM. Further clinical and mechanistic studies are warranted.

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Section: Discussionsupporting

confidence: 91%

Section: Discussionsupporting

confidence: 90%

Chinese Herbal Medicine to Reduce Radiation-Induced Oral Mucositis in Head and Neck Cancer Patients: Evidence From Population-Based Health Claims

Livneh

Chen

et al. 2021

Integr Cancer Ther

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“…The current treatment option for NPC is chemoradiation, however, this approach is said to function more efficiently for individuals with early-stage NPC than for those with late-stage NPC and regional tumor metastases (Tseng et al, 2019). In addition, the 5-year rate of survival of patients is just about 50%.…”

Section: Introductionmentioning

confidence: 99%

Ponicidin Induces Apoptosis and Inhibits Tumor Growth in C666-1 Nasopharyngeal Cancer Cells

Shen,

Zhang,

Hou

et al. 2023

Pharmacognosy Magazine

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Background Nasopharyngeal carcinoma (NPC), predominant in Southern China and Southeast Asia, is a malignant tumor that arises from the epithelial lining of the nasopharynx. Current NPC treatments result in unfavorable side effects. Natural compounds with anti-proliferative capabilities are gaining popularity as a way to mitigate the toxicity of radiation and synthetic antitumor drugs. Ponicidin, an ent-kaurane diterpenoid, has been demonstrated to possess several pharmacological activities, including antitumor, antibacterial, immunoregulatory, antiviral, and anti-inflammatory properties. Materials and Methods In the current investigation, the anti-carcinogenic activity of Ponicidin against nasopharyngeal cell line C666-1, has been investigated. The influence of Ponicidin on cell viability, apoptotic induction, mitochondrial membrane potential (MMP), reactive oxygen species (ROS) generation, and apoptotic markers has been examined. Doxorubicin was selected as the positive control for the experiments. Results The effect of Ponicidin on the viability of C666-1 cells revealed that its cytotoxic potential increased in a dose-dependent pattern and the optimum concentration chosen for further experiments was 7.5 µM. The Ponicidin-treated cells demonstrated a significant increase in the amount of TBARS, whereas it reduced the activity of superoxide dismutase (SOD) and glutathione (GSH) levels, indicating augmented oxidative stress and lower antioxidant activity in the C666-1 cells. The acridine orange/ethidium bromide (AO/EtBr) staining technique was used to assess morphological changes with respect to apoptosis, which confirmed its apoptotic nature. Furthermore, Ponicidin elevated the ROS generation, modified the mitochondrial membrane permeability, elevated the apoptotic marker levels (caspase-3, caspase-9, and Bax) and reduced the Bcl-2 expression in C666-1 cell lines. Conclusion The findings suggest that Ponicidin successfully inhibited cancer cell proliferation by following the mitochondrial apoptotic pathway and thus could be effectively utilized as a potent anti-cancer agent for the treatment of nasopharyngeal cancer.

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Herbal compounds as promising therapeutic agents in precision medicine strategies for cancer: A systematic review

Tayeb,

Kusuma,

Osman

et al. 2024

Journal of Integrative Medicine

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Chinese herbal products for nasopharyngeal carcinoma: A population-based registry study

Cited by 4 publications

References 46 publications

Chinese Herbal Medicine to Reduce Radiation-Induced Oral Mucositis in Head and Neck Cancer Patients: Evidence From Population-Based Health Claims

Chinese Herbal Medicine to Reduce Radiation-Induced Oral Mucositis in Head and Neck Cancer Patients: Evidence From Population-Based Health Claims

Ponicidin Induces Apoptosis and Inhibits Tumor Growth in C666-1 Nasopharyngeal Cancer Cells

Herbal compounds as promising therapeutic agents in precision medicine strategies for cancer: A systematic review

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