Chinese herbs combined with Western medicine for severe acute respiratory syndrome (SARS)

Liu, Xuemei; Zhang, Mingming; He, Lin; Liu, You‐Ping

doi:10.1002/14651858.cd004882.pub3

Cited by 126 publications

(96 citation statements)

References 10 publications

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“…Severe acute respiratory syndrome (SARS) first appeared in 2002 in China. In mainland China about 50% of patients were treated with Chinese herbal medicine as an adjunct therapy in addition to Western medicine (see ), and some positive effects in SARS patients had been reported (see (Liu et al, 2008)). By screening a large number of Chinese herbs (Ho et al, 2007) emodin was identified as an effective component of Polygonaceae to block the interaction of the SARS-coronavirus spike protein (SARS-CoV S protein) with the angiotensin-converting enzyme 2 (ACE2) and to reduce the infection by S protein-pseudo-typed retrovirus.…”

Section: Introductionmentioning

confidence: 99%

Emodin inhibits current through SARS-associated coronavirus 3a protein

et al. 2011

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The open-reading-frame 3a of SARS coronavirus (SARS-CoV) had been demonstrated previously to form a cation-selective channel that may become expressed in the infected cell and is then involved in virus release. Drugs that inhibit the ion channel formed by the 3a protein can be expected to inhibit virus release, and would be a source for the development of novel therapeutic agents. Here we demonstrate that emodin can inhibit the 3a ion channel of coronavirus SARS-CoV and HCoV-OC43 as well as virus release from HCoV-OC43 with a K1/2 value of about 20 μM. We suggest that viral ion channels, in general, may be a good target for the development of antiviral agents.

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Section: Introductionmentioning

confidence: 99%

Emodin inhibits current through SARS-associated coronavirus 3a protein

et al. 2011

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“…Recent studies have demonstrated remarkable beneficial actions of luteolin through its anti-inflammatory activity. The research of modern scientists has shed new light on honeysuckle in the treatment of SARS and H1N1 influenza [13][14][15] . Luteolin protects mice against LPSinduced toxicity, alleviates bronchoconstriction and airway hyperreactivity in ovalbumin-sensitized mice, and decreases Chlamydia pneumoniae infection-induced inflammatory reactions [16][17][18] .…”

Section: Introductionmentioning

confidence: 99%

Protective effects of luteolin against lipopolysaccharide-induced acute lung injury involves inhibition of MEK/ERK and PI3K/Akt pathways in neutrophils

Lee¹,

Chen

et al. 2010

Acta Pharmacol Sin

100

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“…There are several convincing arguments for integration of these disparate systems of medicine. Integration is already helping patients with many chronic diseases [3,4], severe acute respiratory syndrome (SARS) [5], AIDS [6] and etc. Moreover, integration would be more economical for the health care system [7].…”

Section: Introductionmentioning

confidence: 99%

Developing clinical practice guidelines for the integration of Chinese medicine and biomedicine: A new process

Shi

Zhong

Zhang

et al. 2016

European Journal of Integrative Medicine

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A B S T R A C TIntroduction: Despite the integration of Chinese medicine and biomedicine which has emerged in clinical practice worldwide, a comprehensive development process for clinical practice guidelines (CPG) has up to now been missing. A valid method for the rational use of predictions for herb-drug interaction is a biggest challenge in guideline development process. Methods: This article summarises the development process by reviewing key literature from CPG developers. It focuseson key methods and challenges specific to CPGs for integration by using text mining and bioinformatics to provide a powerful adjunct to CPG development. Results: The guideline development process identified, together with new approaches, incorporates evidence-based methodology and provides better decisions through analysis of uncertain herb-drug interaction.Conclusions: This new process used three basic phases (preparation, development, and finalization) and seven steps providing a set of methodological principles for CPG development intergrating Chinese medicine and biomedicine.

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Chinese herbs combined with Western medicine for severe acute respiratory syndrome (SARS)

Cited by 126 publications

References 10 publications

Emodin inhibits current through SARS-associated coronavirus 3a protein

Emodin inhibits current through SARS-associated coronavirus 3a protein

Protective effects of luteolin against lipopolysaccharide-induced acute lung injury involves inhibition of MEK/ERK and PI3K/Akt pathways in neutrophils

Developing clinical practice guidelines for the integration of Chinese medicine and biomedicine: A new process

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