This paper outlines the collaborative efforts between the Korea Aerospace Research Institute (KARI) and the National Aeronautics and Space Administration (NASA) Johnson Space Center (JSC) for the Flight Dynamics (FD) operation of the Korea Pathfinder Lunar Orbiter (KPLO). From the outset of the KPLO program, the joint KARI KPLO FD team and NASA JSC Flight Operations Directorate (FOD) have devoted significant time and effort towards ensuring the mission’s success. This paper begins by introducing the aims and scope of the collaborative work, followed by a detailed description of the efforts made between the KPLO FD team and JSC FOD. This includes the top-level concept, interface architecture, test results, established operation procedures/timeline, and the summary of the joint rehearsal conducted. Finally, the paper discusses the challenges and lessons learned from this journey, particularly from the practical FD operational perspectives. Thanks to the joint team’s collaborative efforts, KPLO has successfully entered lunar orbit and is performing its mission exceptionally well. The joint experience has fostered mutual trust between KARI and NASA JSC, serving as a foundation for further cooperation and collaboration. The efforts and outcomes described in this work will provide valuable insights to experts worldwide who are willing to foster similar international collaborations in the future.