Chinese patent medicine Fei-Liu-Ping ointment as an adjunctive treatment for non-small cell lung cancer: protocol for a systematic review

Zheng, Hongliang; He, Shulin; Li, Rui; Xu, Xinyao; Xu, Tao; Chen, Shuntai; Guo, Qiujun; Gao, Yebo; Bai, Hua

doi:10.1136/bmjopen-2016-015045

Cited by 6 publications

(4 citation statements)

References 12 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…With the development in pharmacology, the constituents of many Chinese herbal medicines have been separated. Therefore, the mechanisms of Chinese herbal medicines for disease treatment have gradually become clear, and in recent years an increasing number of studies have applied Chinese herbal medicine in the treatment of cancer . Therefore, this study explored the effects of the herbal medicine E. prostrata extract (EPE) on oral cancer.…”

Section: Discussionmentioning

confidence: 99%

Antimetastatic effects of Eclipta prostrata extract on oral cancer cells

Liao

Chuang

Hsieh

et al. 2018

Environmental Toxicology

View full text Add to dashboard Cite

Eclipta prostrata, a traditional Chinese medication, has been used for the treatment of several diseases. However, the molecular mechanism underlying the effects of Eclipta prostrata extracts (EPE) on human oral cancer cell metastasis remains unclear. We thus examined the effects of EPE on metastasis promoting proteins in oral cancer. Our results revealed that the EPE attenuated SCC-9, HSC-3, and TW2.6 cell migration and invasiveness by reducing matrix metalloproteinase (MMP)-2 enzyme activities. In addition, Western blot analysis revealed that EPE significantly reduced the levels of phosphorylated extracellular signal-regulated kinase 1/2 (ERK 1/2) but not those of c-Jun N-terminal kinase (JNK) 1/2 and p38. In conclusion, we found that EPE could inhibit oral cancer metastasis through the inhibition of MMP-2 expression. Therefore, EPE may be used to prevent the metastasis of oral cancer, and has the potential to be applied to cancer treatment.

show abstract

Section: Discussionmentioning

confidence: 99%

Antimetastatic effects of Eclipta prostrata extract on oral cancer cells

Liao

Chuang

Hsieh

et al. 2018

Environmental Toxicology

View full text Add to dashboard Cite

show abstract

“…Data are represented as the mean ± SEM. * P < 0.05, * * * P < 0.001 vs. MO 8. Evidence-Based Complementary and Alternative Medicine addition, compared to those of MO mice, PDGF and PDGFR protein expression were obviously decreased in the serum of CTX-treated MO mice (P < 0.01 and P < 0.05, respectively,…”

mentioning

confidence: 92%

“…Traditional Chinese medicine (TCM) has been shown to be effective in the treatment of lung cancer, especially in decreasing the risk of tumour recurrence and metastasis [6,7]. Using systematic reviews and meta-analyses, scholars have recently reported that Chinese herbal medicine could improve survival, quality of life, and immune suppression and reduce tumour recurrence and metastasis in lung cancer patients by alleviating immune suppression [7,8].…”

Section: Introductionmentioning

confidence: 99%

“…FLP ointment is a yinnourishing, toxin-removing, and blood-activating formula of TCM. Previous clinical studies have shown that FLP ointment possessed many marked anticancer properties, such as relieving the manifested symptoms, ameliorating the side effects of radiotherapy and chemotherapy, and reducing the dose of medication required, thus improving the quality of life in lung cancer patients [8][9][10]. FLP ointment is produced by the Beijing Huashen Pharmaceutical Co., LTD. as a hospital preparation (SFDA approval number Z20050851).…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Antiangiogenesis Roles of Exosomes with Fei‐Liu‐Ping Ointment Treatment are Involved in the Lung Carcinoma with the Lewis Xenograft Mouse Model

Zheng

Liu²,

Fan

et al. 2020

Evidence-Based Complementary and Alternative Medicine

View full text Add to dashboard Cite

Exosomes display efficient biocompatibility and represent valuable vehicles for drug or effective material delivery in a tumourtherapeutic approach. Following treatment with Fei-Liu-Ping (FLP) ointment, a traditional Chinese herbal formula, which is used for treating lung cancer patients, could inhibit lung carcinoma growth in clinical and animal studies. In the present study, the values of VEGF and PDGF, which were closely related to angiogenesis, were estimated in serum and carcinoma tissue exosomes to unveil the FLP effects on angiogenesis. e common inflammatory factors of IL-6, IL-1β, TNF-α, and TGF-β in serum exosomes were also detected with the Lewis xenograft model. Methods. Male C57BL/6 mice were randomly divided into four groups, namely, normal, model, cyclophosphamide (CTX), and FLP treatment groups. Histological structures were observed and imaged by H&E. CD31 expressions in tumour tissues were detected by immunofluorescence (IF) and western blot (WB). VEGF, PDGF, and PDGFR levels in exosomes, serum, tumour, and lung tissues were detected by enzyme-linked immunosorbent assay (ELISA), immunohistochemistry (IHC), and WB, respectively. IL-6, IL-1β, TNF-α, and TGF-β levels in exosomes were measured by multiplex immunoassay panels. Results. e results showed that FLP had tumour growth inhibition rate (39.31%). CD31 protein expression was obviously decreased in tumour tissues of CTX-and FLP-treated MO mice, compared to that of MO mice (P < 0.05 or P < 0.001). VEGF, PDGF, and PDGFR expression levels with FLP treatment were downregulated in exosomes, serum, tumour, and lung tissues compared to model group (P < 0.05 or P < 0.01). e expressions of IL-6, IL-1β, and TNF-α were downregulated in exosomes compared to the model group (P < 0.05 or P < 0.01). Conclusions. is study suggested that FLP had the ability of inhibiting tumourigenesis in a Lewis lung xenograft mouse model, whose therapeutic mechanisms might relate with the downregulation of angiogenesis factor and tumour inflammatory cytokines levels.

show abstract