Chinese single herbs and active ingredients for postmenopausal osteoporosis: From preclinical evidence to action mechanism

Lin, Jing; Wang, Yan; Zhang, Na; Gober, Hans-Jürgen; Li, Da‐Jin; Wang, Ling

doi:10.5582/bst.2017.01216

Cited by 80 publications

(50 citation statements)

References 88 publications

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“…Intriguingly, osthole could dose‐dependently counteract the inhibition of ethanol on the proliferation and osteogenic differentiation of BMSCs. In addition, osthole could dose‐dependently abolish the inhibition of ethanol on β‐catenin expression to augment osteogenesis, in line with previous reports . In vivo, typical pathological changes of hip osteonecrosis were observed by micro‐CT scanning and H & E staining in the ethanol group, whereas only mild osteonecrosis was presented in the animal with supplementary osthole administration.…”

Section: Discussionsupporting

confidence: 89%

Osthole stimulates bone formation, drives vascularization and retards adipogenesis to alleviate alcohol‐induced osteonecrosis of the femoral head

Zhu

Liu

et al. 2020

J Cellular Molecular Medi

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Characteristic pathological changes in osteonecrosis of the femoral head (ONFH) include reduced osteogenic differentiation of bone mesenchymal stem cells (BMSCs), impaired osseous circulation and increased intramedullary adipocytes deposition. Osthole is a bioactive derivative from coumarin with a wide range of pharmacotherapeutic effects. The aim of this study was to unveil the potential protective role of osthole in alcohol‐induced ONFH. In vitro, ethanol (50 mmol/L) remarkably decreased the proliferation and osteogenic differentiation of BMSCs and impaired the proliferation and tube formation capacity of human umbilical vein endothelial cell (HUVECs), whereas it substantially promoted the adipogenic differentiation of BMSCs. However, osthole could reverse the effects of ethanol on osteogenesis via modulating Wnt/β‐catenin pathway, stimulate vasculogenesis and counteract adipogenesis. In vivo, the protective role of osthole was confirmed in the well‐constructed rat model of ethanol‐induced ONFH, demonstrated by a cascade of radiographical and pathological investigations including micro‐CT scanning, haematoxylin‐eosin staining, TdT‐mediated dUTP nick end labelling, immunohistochemical staining and fluorochrome labelling. Taken together, for the first time, osthole was demonstrated to rescue the ethanol‐induced ONFH via promoting bone formation, driving vascularization and retarding adipogenesis.

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Section: Discussionsupporting

confidence: 89%

Osthole stimulates bone formation, drives vascularization and retards adipogenesis to alleviate alcohol‐induced osteonecrosis of the femoral head

Zhu

Liu

et al. 2020

J Cellular Molecular Medi

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“…Almost two-thirds of the world’s population consume tea every day and black tea comprises approximately 80% of all tea consumed ( Huang et al, 2009 ; Nie et al, 2014 ; Lin et al, 2017 ). An epidemiological studies suggested that postmenopausal women who drank tea had higher BMD measurements ( Hegarty et al, 2000 ; Nash and Ward, 2016 ).…”

Section: Discussionmentioning

confidence: 99%

Effect of Black Tea Extract and Thearubigins on Osteoporosis in Rats and Osteoclast Formation in vitro

Liang

Zhang

et al. 2018

Front. Physiol.

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Background: Osteoporosis is a major health problem that is closely related to substantial morbidity, mortality and decline in life quality for the aging population. Although previous studies and epidemiological evidence have demonstrated an association between black tea consumption and the prevention of bone loss, the underlying mechanism remains unclear. So, the effect of black tea extract (BTE) and thearubigins (TRs) on osteoporosis in rats and osteoclast formation in vitro were investigated.Methods: In vivo, ovariectomized (OVX) rats were used to establish osteoporosis models. To validate the model and study the effects of BTE and TRs on osteoporosis, the female Wistar rats were divided into a sham-operated group and five OVX groups including model, Xian-Ling-Gu-Bao (XLGB) (as a positive control), BTE, TRs low-dose, and TRs high-dose group. The rats in the four treatment groups were given the corresponding test sample for 12 weeks. Then, the body weight, femur indices, and serum biomarkers were examined and analyzed. In vitro, RAW264.7 murine macrophages were used as model of osteoclast formation. The effects of BTE and TRs on osteoclasts formation and the specific genes and protein levels of osteoclasts were determined.Results: Although there was no significant effect on the OVX-induced body weight gain by BTE or TRs, the levels of maximum bending force, cortical bone thickness and biomarker of bone resorption (acid phosphatase) can be significantly ameliorated by BTE or TRs in OVX rats. Furthermore, both of BTE and TRs can inhibit the osteoclastogenesis and diminish the expression levels of the related genes and proteins.

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“…Poncirin is a flavonoid obtained from the fruit of Poncirus trifoliata. It is widely explored antiosteoporotic drug involved in regulation OPG/RANKL ratio, extracellular-signal-regulated kinase/c-Jun N terminal kinase/mitogen-activated protein kinase (ERK/JNK/MAPK), estrogen receptor (ER), bone morphogenetic protein (BMP), transforming growth factor (TGF)-β, Wnt/β-catenin, and Notch signaling pathways ( Lin et al, 2017 ). Poncirin when tested in GC induced mice revealed that treatment resulted in enhancement of OC, OPG, mineral nodule formation and mRNA expression and decrease in CTX serum level.…”

Section: Poncirinmentioning

confidence: 99%

Bone Health and Natural Products- An Insight

et al. 2018

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Bone metabolism involves a complex balance between matrix deposition, mineralization, and resorption. Numerous evidences have revealed that dietary components and phytoconstituents can influence these processes, through inhibition of bone resorption, thus exhibiting beneficial effects on the skeleton. Various traditional herbal formulae in ayurvedic and Chinese medicine have shown demonstrable benefits in pharmacological models of osteoporosis. The present review discusses normal bone metabolism and disorders caused by bone disruption, with particular reference to osteoporosis and current therapeutic treatment. Furthermore the effects of constituents from natural products on bone tissue are explained, with relevant evidences of efficacy in various experimental models.

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Chinese single herbs and active ingredients for postmenopausal osteoporosis: From preclinical evidence to action mechanism

Cited by 80 publications

References 88 publications

Osthole stimulates bone formation, drives vascularization and retards adipogenesis to alleviate alcohol‐induced osteonecrosis of the femoral head

Osthole stimulates bone formation, drives vascularization and retards adipogenesis to alleviate alcohol‐induced osteonecrosis of the femoral head

Effect of Black Tea Extract and Thearubigins on Osteoporosis in Rats and Osteoclast Formation in vitro

Bone Health and Natural Products- An Insight

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