Chinese Water-Pipe Smoking and the Risk of COPD

She, Jun; Yang, Ping; Wang, Yuqi; Qin, Xinyu; Fan, Jian‐Gao; Wang, Yi; Gao, Guangsuo; Luo, Guangxiong; Ma, Kaixiang; Li, Baoyan; Li, Caihua; Wang, Xiangdong; Song, Yuanlin; Bai, Chunxue

doi:10.1378/chest.13-1499

Cited by 62 publications

(59 citation statements)

References 23 publications

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“…Moreover, six month WPS exposure caused oxidative stress and DNA damage of the lung. Although some epidemiological studies reported association between WPS and COPD [11,12], experimental evidence on the chronic effects of WPS is lacking. We have recently demonstrated that 1-month nose-only WPS exposure causes lung inflammation and oxidative stress, and increased airway resistance in mice [15].…”

Section: Discussionmentioning

confidence: 99%

“…Acute exposure to WPS has been associated with a decrease in peak expiratory flow rate (PEFR), forced expiratory flow between 25 to 75% of forced vital capacity (FEF 25-75% ), whereas chronic exposure cause a decrease in the forced expiratory volume in one second (FEV 1 ) and forced vital capacity (FVC), FEV 1 /FVC and FEF 25-75% [9,10]. Moreover, association between WPS and COPD has been reported after adjusting for possible confounders such as age and CS [11,12].…”

Section: Introductionmentioning

confidence: 99%

“…Such study is essential because it would provide biological plausibility for the epidemiological and clinical studies linking WPS and chronic adverse respiratory effects (e.g. COPD) [11,12].…”

Section: Introductionmentioning

confidence: 99%

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Chronic Exposure to Water-Pipe Smoke Induces Alveolar Enlargement, DNA Damage and Impairment of Lung Function

Al-Salam

Yuvaraju

Beegam

et al. 2016

Cell Physiol Biochem

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Background/Aim: Epidemiological evidence indicates that water-pipe smoking (WPS) adversely affects the respiratory system. However, the mechanisms underlying its effects are not well understood. Recent experimental studies reported the occurrence of lung inflammation and oxidative stress following acute and subacute exposure to WPS. Here, we wanted to verify the extent of inflammation and oxidative stress in mice chronically-exposed to WPS and to evaluate, for the first time, its effect on alveolar injury and DNA damage and their association with impairment of lung function. Methods: Mice were nose-only exposed to mainstream WPS (30 min/day; 5 days/week for 6 consecutive months). Control mice were exposed using the same protocol to atmospheric air only. At the end of the exposure period, several respiratory parameters were assessed. Results: In bronchoalveolar lavage fluid, WPS increased neutrophil and lymphocyte numbers, lactate dehydrogenase, myeloperoxidase and matrix metallopeptidase 9 activities, as well as several proinflammatory cytokines. In lung tissue, lipid peroxidation, reactive oxygen species, superoxide dismutase activity and reduced glutathione were all increased by WPS exposure. Along with oxidative stress, WPS exposure significantly increased lung DNA damage index. Histologically the lungs of WPS-exposed mice had foci of mixed inflammatory cells infiltration in the interalveolar interstitium which consisted of neutrophils, lymphocytes and macrophages. Interestingly, we found dilated alveolar spaces and alveolar ducts with damaged interalveolar septae, and impairment of lung function following WPS exposure. Conclusion: We show the persistence of lung inflammation and oxidative stress in mice chronically-exposed to WPS and demonstrate, for the first time, the occurrence of DNA damage and enlargement of alveolar spaces and ducts associated with impairment of lung function. Our findings provide novel mechanistic elucidation for the long-term effects of WPS on the respiratory system.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Chronic Exposure to Water-Pipe Smoke Induces Alveolar Enlargement, DNA Damage and Impairment of Lung Function

Al-Salam

Yuvaraju

Beegam

et al. 2016

Cell Physiol Biochem

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“…3 In Chinese water-pipe smokers (a variant on the Middle-Eastern pipe where the tobacco is lit directly instead of using coals) the rate of radiologically diagnosed emphysema was higher than in cigarette smokers or nonsmokers. 4 These clinical data are supported by animal models: chronic airway inflammation with eventual airflow limitation typical of COPD has been demonstrated using water-pipe smoke in mice. Mice exposed to shisha smoke for 30 minutes per day for five days develop neutrophilic inflammation of their airways and an increase in tumor necrosis factor-alpha and interleukin-6 present in broncho-alveolar lavage fluid.…”

Section: A Review Of the Health Effects Of Smoking Shishamentioning

confidence: 87%

A review of the health effects of smoking shisha

Aston¹,

Heron²

2015

Clinical Medicine

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“…Similar to other tobacco products, hookah tobacco confers an increased risk for impairment of pulmonary function (26,27), lung diseases (28,29), periodontal disease (28,30), and cardiovascular disease (8). However, hookah tobacco produces higher levels of toxicants than cigarettes (31).…”

Section: Introductionmentioning

confidence: 99%

Review of hookah tobacco smoking among college students: policy implications and research recommendations

Gathuru¹,

Tarter²,

Klein‐Fedyshin

2015

The American Journal of Drug and Alcohol Abuse

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Background: About 30% of college students have smoked hookah tobacco. Although most students perceive this product to be innocuous and non-addictive, hookah tobacco increases the risk for disease and nicotine dependence. Currently, the US Food and Drug Administration (FDA) does not regulate the manufacture, distribution, or sale of hookah tobacco. Objective: Empirical literature pertaining to hookah tobacco smoking is reviewed with a focus on the implications for regulatory policy. Methods: PubMed, PsycINFO, and Scopus databases were searched to locate articles published in English. The literature search combined

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Chinese Water-Pipe Smoking and the Risk of COPD

Cited by 62 publications

References 23 publications

Chronic Exposure to Water-Pipe Smoke Induces Alveolar Enlargement, DNA Damage and Impairment of Lung Function

Chronic Exposure to Water-Pipe Smoke Induces Alveolar Enlargement, DNA Damage and Impairment of Lung Function

A review of the health effects of smoking shisha

Review of hookah tobacco smoking among college students: policy implications and research recommendations

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