Chiral Auxiliaries for the Synthesis of P-Chiral Phosphorus Derivatives

Synthesis of P-stereogenic 1-phosphanorbornane-derived phosphine–phosphite ligands and application in asymmetric catalysis

“…2,3 A plethora of P-stereogenic phosphines have already been reported; however, the search for better, more efficient and sustainable ligands is still ongoing as the topic remains demanding even in the present day. The discovery of the wellknown cyclohexyl(o-anisyl)methylphosphine (CAMP) and (ethane-1,2-diyl)bis[(2-methoxyphenyl)(phenyl)phosphine] (DIPAMP) used in Rh-catalyzed asymmetric hydrogenation 4 boosted the scientic interest in P-stereogenic [5][6][7][8][9] (or P-chiral, Pchirogenic, P*-) ligands. Despite the challenging synthesis of P*phosphines, a number of methods has been developed with pioneering contributions from Mislow, 10 Knowles, 4 Horner, 11 Börner, 12 Jugé, 13 van Leeuwen and Kamer 14 and many more.…”