Chiral Capillary Electrophoresis of Amphetamine-Type Stimulants

Chinaka, Satoshi; Iio, Reiko; Takayama, Nariaki; Kodama, Shuji; Hayakawa, Kazuichi

doi:10.1248/jhs.52.649

Cited by 12 publications

(10 citation statements)

References 12 publications

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“…Although analyses of MA and its related compounds commonly use GC-MS and LC-MS(-MS) [1][2][3], CE has many advantages especially when chiral analysis is required; CE is fast and cost effective, and gives highresolution separation of target compounds, and chiral separation can be easily accomplished by adding a chiral selector to the BGE [22]. For chiral analysis of MA and its related compounds in human specimens, CE should gain more popularity.…”

Section: Discussionmentioning

confidence: 99%

Reproducible chiral capillary electrophoresis of methamphetamine and its related compounds using a chemically modified capillary having diol groups

et al. 2009

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Excellent reproducibility of chiral capillary electrophoresis for methamphetamine (MA) and its related compounds was obtained using a chemically modifi ed capillary having diol groups. The data were compared with those using an untreated fused-silica capillary and a poly(vinyl alcohol) (PVA)-coated capillary. For fi ve replicate analyses of a standard mixture, relative standard deviations (RSDs) of the migration times of analytes with diol or PVA-coated capillaries were less than 0.1%, which were lower than those obtained with an untreated fused-silica capillary (ca. 0.4%). The diol capillary gave reproducible migration times especially in analyses of real samples, such as crude human urine. In the analyses of fi ve spiked urine samples, the RSD values of migration times of analytes with the diol capillary were not greater than 0.14%, which were much lower than those obtained with the PVA-coated capillary (ca. 1.5%). The proposed method was successfully used for chiral analyses of actual urine samples of MA addicts.

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Section: Discussionmentioning

confidence: 99%

Reproducible chiral capillary electrophoresis of methamphetamine and its related compounds using a chemically modified capillary having diol groups

et al. 2009

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“…Besides, MA has an asymmetric carbon in its structure and thus exists two enantiomers, ( S )‐(+)‐MA and ( R )‐(–)‐MA. Almost all MA distributed in streets includes ( S )‐MA, because ( S )‐MA is 5–10 times more potent than ( R )‐MA with respect to its effect on the central nervous system . On the other hand, it should be noted that some legal drugs are metabolized and change to ( R )‐MA.…”

Section: Introductionmentioning

confidence: 99%

Approaching over 10 000‐fold sensitivity increase in chiral capillary electrophoresis: Cation‐selective exhaustive injection and sweeping cyclodextrin‐modified micellar electrokinetic chromatography

et al. 2016

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A novel and simple method that combines an online concentration technique with an enantioseparation technique for capillary electrophoresis-namely, cation-selective exhaustive injection and sweeping cyclodextrin-modified micellar electrokinetic chromatography (CSEI-sweeping CD-modified MEKC)-realizes the effective enantioseparation of cationic analytes while keeping a significant increase of detection sensitivity. This technique consists of a slight modification of the basic CSEI-sweeping MEKC. The main idea is to simply add an anionic CD as a chiral selector into the micellar buffer including sodium dodecyl sulfate, but not to change any other buffers in order to preserve the online concentration mechanism. When applied to analysis of the street drug, methamphetamine, the method achieved not only a baseline enantioseparation but also limits of detection (LODs; S/N = 3) of 70-90 pg/mL (ppt) for each isomer. This translates to a more than 10 000-fold improvement compared to the LODs by the usual injection method. The present technique, which was made from a slight modification of CSEI-sweeping MEKC, would give an attractive approach that is applicable to almost any analytes for which CSEI-sweeping MEKC is applicable; all that is required is the selection of an appropriate anionic CD to be added to the micellar buffer.

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“…They have been among the most popular illegal psychotropic drugs since the mid-1980s. Recently, for identification and determination of MDMA, various investigation methods such as HPLC [21,22], displacement of anti- bodies [23], high-speed chronoamperometry [24], gas chromatography [25], and capillary electrophoresis [26] have been reported. There has been a growing tendency among Iranian youth for the abuse of ecstasy tablets during the past decade.…”

Section: Introductionmentioning

confidence: 99%

Application of Polyaniline and Polyaniline/Multiwalled Carbon Nanotubes‐Coated Fibers for Analysis of Ecstasy

Khajeamiri¹,

Kobarfard²,

Moghaddam³

2012

Chem Eng & Technol

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A fiber coated by polyaniline (PANI) was obtained through electrochemical deposition and applied for solid-phase microextraction (SPME). The same method was applied for the preparation of an SPME fiber coated by a PANI/multiwalled carbon nanotubes (PANI/MWCNTs) composite. The prepared fibers were employed for extraction of methylenedioxymethamphetamine (MDMA) hydrochloride from aqueous and chloroform samples. The resulting substances were analyzed by gas chromatography-mass spectrometry. The developed method proved to be simple with high reproducibility. The amount of extracted MDMA hydrochloride from aqueous solution and MDMA from chloroform solution by the PANI/MWCNTs fiber was about 3.5-fold and 2-fold that of the one without CNTs. It could be suggested that the composite material with CNTs has both an augmented surface area and an elevated adsorptive capacity which lead to the increased extractive capacity for MDMA.

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Chiral Capillary Electrophoresis of Amphetamine-Type Stimulants

Cited by 12 publications

References 12 publications

Reproducible chiral capillary electrophoresis of methamphetamine and its related compounds using a chemically modified capillary having diol groups

Reproducible chiral capillary electrophoresis of methamphetamine and its related compounds using a chemically modified capillary having diol groups

Approaching over 10 000‐fold sensitivity increase in chiral capillary electrophoresis: Cation‐selective exhaustive injection and sweeping cyclodextrin‐modified micellar electrokinetic chromatography

Application of Polyaniline and Polyaniline/Multiwalled Carbon Nanotubes‐Coated Fibers for Analysis of Ecstasy

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