Chiral cyclopropenimine-catalyzed enantioselective Michael additions between benzophenone-imine of glycine esters and α,β-unsaturated pyrazolamides

Abstract

A highly enantioselective Michael additions between benzophenone-imine of glycine esters and β-substituted α,β-unsaturated pyrazolamides has been realized by using 10 mol% of a chiral cyclopropenimine (Lambert catalyst, CSB-1) as organosuperbase...

DBU‐Catalyzed Glutamation of Phenols, Thiophenols, Secondary Amines and Imides

“…Recently, we reported highly diastereoselective 1,8diazabicyclo[5.4.0]undec-7-ene (DBU) catalyzed Michael additions of benzophenone-imines of glycine esters with β- substituted α,β-unsaturated isoxazoles and pyrazolamides [12] (Scheme 1a). Phenols, thiophenols, secondary amines and imides are common feedstock and serve as key building blocks for the synthesis of valuable products.…”