2019
DOI: 10.1002/elps.201900294
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Chiral metal‐organic cages used as stationary phase for enantioseparations in capillary electrochromatography

Abstract: Since some metal‐organic cages (MOCs) have been synthesized in past several years, the applications of MOCs such as drug delivery, molecular recognition, separation, catalysis, and gas storage, etc. have been witnessed with a significant increase. However, to the best of our knowledge, so far no one has used MOCs as chiral stationary phase to separate chiral compounds in CEC. In this study, three MOCs were developed as the stationary phase for CEC separation of enantiomers. The MOCs coated capillary column sho… Show more

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Cited by 22 publications
(10 citation statements)
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“…Enantioseparation by CEC was also achieved using open-tubular columns coated with coordination cages. 118 Such columns were prepared by introducing a cage solution into a pretreated capillary, followed by flushing with N2 and heating, to form a thin layer of cage on the capillary inner wall. The tubular column coated with 17 was able to separate the enantiomers of chiral amines, alcohols, and ketones, with good repeatability and stability.…”
Section: Cage-decorated Separation Columnsmentioning
confidence: 99%
“…Enantioseparation by CEC was also achieved using open-tubular columns coated with coordination cages. 118 Such columns were prepared by introducing a cage solution into a pretreated capillary, followed by flushing with N2 and heating, to form a thin layer of cage on the capillary inner wall. The tubular column coated with 17 was able to separate the enantiomers of chiral amines, alcohols, and ketones, with good repeatability and stability.…”
Section: Cage-decorated Separation Columnsmentioning
confidence: 99%
“…Moreover, this chiral complex exhibits enantioselective binding of small guest molecules, such as 2-butanol (Figure 19). The ability to bind guest molecules and the enantiopure nature of [Zn382] was the basis of its application in the enantioseparations of chiral organic compounds by using gas chromatography [110] or capillary electrochromatography [111,112]. The reactions of [3 + 3] triphenolic calixsalen macrocycles, such as 8 and 39 or similar imines with metal salts do not lead to complexes of these macrocycles but to complexes of the contracted [2 + 2] forms or acyclic ligands [23,24,109].…”
Section: [3 + 3] Macrocyclesmentioning
confidence: 99%
“…The BINOL derivatives were coated onto the pre-treated capillary column using a permanent coating method [41,42]. Before coating, the BINOL derivatives (40 mg) were dissolved in dichloromethane (2 mL) and degassed for 10 min by ultrasound.…”
Section: Preparation Of Open-tubular Columns Coated With Binol Deriva...mentioning
confidence: 99%