Chiral MoSe₂ Nanoparticles for Ultrasensitive Monitoring of Reactive Oxygen Species In Vivo

Abstract

Reactive oxygen species (ROS) are involved in neurodegenerative diseases, cancer, and acute hepatitis, and quantification of ROS is critical for the early diagnosis of these diseases. In this work, a novel probe is developed, based on chiral molybdenum diselenide (MoSe2) nanoparticles (NPs) modified by the fluorescent molecule, cyanine 3 (Cy3). Chiral MoSe2 NPs show intensive circular dichroism (CD) signals at 390 and 550 nm, whereas the fluorescence of Cy3 at 560 nm is quenched by MoSe2 NPs. In the presence of ROS, the probe reacts with the ROS and then oxidates rapidly, resulting in decreased CD signals and the recovery of the fluorescence. Using this strategy, the limit of detection values of CD and fluorescent signals in living cells are 0.0093 nmol/106 cells and 0.024 nmol/106 cells, respectively. The high selectivity and sensitivity to ROS in complex biological environments is attributed to the Mo4+ and Se2− oxidation reactions on the surface of the NPs. Furthermore, chiral MoSe2 NPs are able to monitor the levels of ROS in vivo by the fluorescence. Collectively, this strategy offers a new approach for ROS detection and has the potential to inspire others to explore chiral nanomaterials as biosensors to investigate biological events.

Molybdenum disulfide nanostructures coupled with metal plasmonics for improved electronic and photonic performances

“…As a response, the integration of various advanced materials with MoS 2 nanostructures was proposed to strengthen the performance of MoS 2 in various fields. [15][16][17] Plasmonic materials, primarily those of metal (Au, Ag, Cu, etc.) nanoparticles (NPs), have been widely studied in the last decades.…”

“…As a response, the integration of various advanced materials with MoS 2 nanostructures was proposed to strengthen the performance of MoS 2 in various fields. 15–17…”

Green Nanopesticide: pH Response and Molybdenum Selenide Carrier with Photothermal Effect to Transport Prochloraz to Inhibit Sclerotinia Disease

“…In recent years, a two-dimensional layered transition-metal compound MX 2 (M = Mo; X = Se) has attracted extensive attention in the fields of photocatalysis, sensors, and biomedicine because of its good electrical and optical properties, large specific surface area, high loading capacity, and controllable size. − Most importantly, molybdenum selenide (MoSe 2 ) nanoparticles possess negligible photoluminescence, which ensures efficient photothermal conversion . According to previous reports, the research on MoSe 2 nanomaterials has mainly focused on electrochemical energy storage, photocatalytic hydrogen evolution, and sensors, but the research and application in drug-loaded antibacterial have been limited. − In particular, appropriate amounts of molybdenum and selenium are helpful to increase the crop yield, improve the quality of agricultural products, enhance the antioxidant capacity of plants, and improve photosynthesis. , Therefore, MoSe 2 can be used as a new nanocarrier. Under proper acidic conditions, the protonation of weak acidic groups of poly­(acrylic acid) (PAA) shows a shrinking conformation, resulting in an increase of the membrane pore size.…”

Near-Infrared Chiroptical Activity Titanium Dioxide Supraparticles with Circularly Polarized Light Induced Antibacterial Activity

“…Chiral substances exhibit distinct behaviors in terms of transmission, scattering, and absorption when interacting with left-handed circularly polarized light (LCP) and right-handed circularly polarized light (RCP) . Chirality plays an important role in molecular recognition, chiral separations, chemical and biological sensors, and optical devices, making the development of chiral metarials highly significant for various scientific disciplines. Over recent years, there has been significant development in the preparation of inorganic nanomaterials with chiroptical activity. − Inorganic nanomaterials exhibiting chiroptical activity based on electronic transitions have been extensively studied .…”