Chiral Nanoporous Metal‐Organic Frameworks with High Porosity as Materials for Drug Delivery

Sun, C. P.; Qin, Chao; Wang, Chungang; Su, Zhong‐Min; Wang, Shuang; Wang, Xin-Long; Yang, Guang‐Sheng; Shao, Kui‐Zhan; Lan, Ya‐Qian; Wang, Enbo

doi:10.1002/adma.201102538

Cited by 400 publications

(215 citation statements)

References 52 publications

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“…[1][2][3][4] They have received considerable attention in the past two decades because of their very promising potential in industrial applications, such as adsorption/separation, 5,6 drug delivery, 7,8 chemical sensing, 9,10 and catalysis. 11,12 Nevertheless, almost all reported MOF materials to date are microporous structures with pore sizes below 2 nm.…”

Section: Introductionmentioning

confidence: 99%

Template synthesis of hierarchical porous metal–organic frameworks with tunable porosity

Duan

Zhang

et al. 2017

RSC Adv.

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Hierarchical porous metal-organic frameworks (HP-MOFs) with tunable porosity are highly valuable for many applications. Here, we developed a versatile solvothermal method to synthesize various HP-MOFs, such as Cu-BTC and ZIF-8, by using an organic amine as the template. The resulting HP-MOF products were characterized by a complementary combination of X-ray powder diffraction, Fourier-transform infrared spectroscopy, scanning electron microscopy, transmission electron microscopy, nitrogen adsorption-desorption isotherms, pore size distributions analysis, thermogravimetric analysis, and density functional theory calculations. The results indicated that the obtained HP-MOF products had high thermal stability and contained multimodal hierarchically porous structures with mesopores or macropores interconnected with micropores. In addition, the porosities of the produced HP-MOFs could be easily tuned by controlling the amount of the template. The introduced organic amine served as the template to direct the formation of mesopores and macropores. Furthermore, the synthesis route is highly versatile as other organic amines (e.g., N,N-dimethylhexadecylamine and N,Ndimethyltetradecylamine) can also be used as templates to synthesize HP-MOFs. The method developed in this work may offer a new direction to synthesize various stable HP-MOFs with tunable porosities for a wide range of applications.

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Section: Introductionmentioning

confidence: 99%

Template synthesis of hierarchical porous metal–organic frameworks with tunable porosity

Duan

Zhang

et al. 2017

RSC Adv.

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“…Meanwhile, it is more extended and flexible than other triazine‐based ligands,7 hence preferring to form a ribbon‐like sheet then bent into the calix‐like shape by metal‐ligand orientation. More importantly, the ligand can serve as an excellent electron donor to generate the radical‐ion species.…”

mentioning

confidence: 99%

Calix‐Like Metal–Organic Complex for High‐Sensitivity X‐Ray‐Induced Photochromism

Zhang

2015

Advanced Science

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Metal‐organic complexes (MOCs) as promising candidates for directly visual X‐ray detection at room temperature are rare and discovered unexpectedly, even though every crystalline material needs X‐ray diffraction studies. Here, we report a rational strategy of mimicking host‐guest system for developing high‐sensitive X‐ray‐induced photochromic materials. Two resulting calix‐like metal‐organic complexes (cMOC‐1 and cMOC‐2) were prepared by encapsulating the electron‐capturing “guest” into the cavity of calix‐like electron‐donating “host.” One of them (cMOC‐1) achieves instantaneous X‐ray‐induced photochromism and easy recovery by synergizing the aprotic matrix of MOC and similar host‐guest interaction. Their strikingly different response to X‐ray irradiation resulting from the structural difference demonstrates the feasibility and acceptability of our design strategy. This strategy may open new perspectives for developing high‐performance photo‐responsive functional materials.

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“…Recently, Liu and his co-worker have successfully prepared a novel (3,4)-connected topology PMOF (1) with a schläfli symbol of {4•6 2 •8 3 }{4•6 4 •8}{4•6 5 } 4 using the super molecular building block (SBB) strategy [13]. It features three types of cages with multiple sizes and shapes and exhibits high performance for CO 2 capture and selectivity of CO 2 /CH 4 and C 3 H 8 /CH 4 .…”

Section: Introductionmentioning

confidence: 99%

“…Férey and co-workers firstly proposed the use of porous MOFs (such as, MIL-100 and MIL-101) as controlled delivery systems [1b]. This method strongly depends on the loading capacity of the porous materials, as well their pore size and conformation [4]. Polyhedral metal-organic frameworks (PMOFs) are different from traditional MOFs, they have cages carrying large voids and open-channel-type pores.…”

Section: Introductionmentioning

confidence: 99%

A 3D polyhedral metal–organic framework as drug carrier for controllable release

Zhou¹,

Wang²,

Wu³

et al. 2018

Bull. Chem. Soc. Eth.

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ABSTRACT. A new fabrication of {[H3O][Cu6(tpta)3(DMA)4(COO)]•12H2O•7DMA}(1) was used as a drug vehicle of 5-fluorouracil (5-FU) for drug delivery. The incorporation of the drug 5-FU into the 1 was around 47.3 wt% per gram of dehydrated 1. Cargo release behavior and material degradation profile were also investigated under different mdeium. 5-FU is released in a highly controlled and progressive manner with 92% of the drug release after 96 h at acidic condition and with 88% after 96 h at PBS. In vitro cytotoxicity assays indicated that the 1 possesses no obvious cytotoxicity. The results provide a new avenue for MOFs to be used as potential drug delivery.

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Chiral Nanoporous Metal‐Organic Frameworks with High Porosity as Materials for Drug Delivery

Cited by 400 publications

References 52 publications

Template synthesis of hierarchical porous metal–organic frameworks with tunable porosity

Template synthesis of hierarchical porous metal–organic frameworks with tunable porosity

Calix‐Like Metal–Organic Complex for High‐Sensitivity X‐Ray‐Induced Photochromism

A 3D polyhedral metal–organic framework as drug carrier for controllable release

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