2017
DOI: 10.1039/c7sc01316g
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Chiral nanoprobes for targeting and long-term imaging of the Golgi apparatus

Abstract: The targeting and long-term imaging of the Golgi apparatus have been realized via l-cysteine functionalized nanoprobes.

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Cited by 185 publications
(124 citation statements)
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“…Therefore, we designed and synthesized a new O 2 ˙ – two-photon fluorescence probe that targets the Golgi and dynamically and reversibly detects O 2 ˙ – levels ( cis -caffeic acid, CCA, Scheme 1). The CCA probe was designed using the following strategy: 1, a caffeic acid group for detecting the dynamic responses of O 2 ˙ – that displays blue fluorescence; and 2, an l -cysteine group for targeting the Golgi apparatus 30. Because Golgi apparatus contains many receptors for the cysteine residues or cysteine rich region 32,33.…”
Section: Introductionmentioning
confidence: 99%
“…Therefore, we designed and synthesized a new O 2 ˙ – two-photon fluorescence probe that targets the Golgi and dynamically and reversibly detects O 2 ˙ – levels ( cis -caffeic acid, CCA, Scheme 1). The CCA probe was designed using the following strategy: 1, a caffeic acid group for detecting the dynamic responses of O 2 ˙ – that displays blue fluorescence; and 2, an l -cysteine group for targeting the Golgi apparatus 30. Because Golgi apparatus contains many receptors for the cysteine residues or cysteine rich region 32,33.…”
Section: Introductionmentioning
confidence: 99%
“…Aer that, efforts in the direction of creating inorganic chiral nanoobjects are largely directed towards combining the optical properties of chiral molecules with metal or semiconductor nanoparticles, especially thiolated chiral molecules capping nanoparticles. [2][3][4][5][6][7][8][9][10][11][12][13] However, to the best of our knowledge, a very limited number of cases as to the efforts towards the development of chiral light emitting particles have been made, [14][15][16][17] and therefore, how to obtain both highly luminescent and optically active particles nearly remains in burgeon stage and a worthwhile yet challenging undertaking, considering that chiral luminescent nanosized probes would provide very useful tools for both chemistry and biology.…”
Section: Introductionmentioning
confidence: 99%
“…Carbon quantum dots and silica NPs could target the Golgi to monitor its changes when they are modified with l-cysteine. 103 Gong's team repeatedly proved that chondroitin sulfate (CS) nanomicelles targeted the Golgi since the glycosyltransferases in the Golgi could specifically bind to CS. 104,105 However, it should be pointed out that compared with the targeting of the mitochondria and nuclei, the subcellular targeting of the ER and Golgi is still in its infancy, with not enough information available to apply comprehensive design strategies.…”
Section: Er and Golgi Targeting Nanoformulationsmentioning
confidence: 99%