Chiral Nanozymes–Gold Nanoparticle‐Based Transphosphorylation Catalysts Capable of Enantiomeric Discrimination

Chen, Jack L.‐Y.; Pezzato, Cristian; Scrimin, Paolo; Prins, Leonard J.

doi:10.1002/chem.201600853

Cited by 61 publications

(32 citation statements)

References 48 publications

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“…This resulted in the spontaneous formation of chiral bimetallic catalytic sites that display different activities (determined as k cat ) towards the enantiomers of 2‐hydroxypropyl p‐nitro‐m‐trifluoromethylphenyl phosphate. Substrate selectivity was observed when the nanozyme was applied to the cleavage of the dinucleotides UpU, GpG, ApA, and CpC, and remarkable differences in reactivity were also observed for the cleavage of the enantiomerically pure dinucleotide UpU . The selectivities observed were one order of magnitude lower than those typically presented by natural enzymes, nevertheless, they represented one of the few cases reported in the literature of enantioselective phosphate cleavage by a nano catalyst …”

Section: Nanocatalysts For the Hydrolysis Of Phosphoric Acid Estersmentioning

confidence: 85%

Hydrolytic Nanozymes

et al. 2020

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In 2004 we first reported catalytic nanoparticles, that are able to cleave phosphate diesters with very high efficiency (Angew. Chem. Int Ed, 2004, 43, 6165–6169) and dubbed them “nanozymes” for the similarity of their behavior with natural enzymes, both in terms of efficiency and mechanism of action. Since then the field has impressively expanded and a search on the web of science at the time of submitting this contribution returned almost 1,000 entries. This minireview highlights what has been done in the field focusing specifically on hydrolytic nanozymes, the focal point of the research in our group since its very beginning. Special emphasis is given to the advantage of bringing catalytic units in the confined space of a nanosystem in terms of inducing the cooperation between them, favoring the interaction with substrates, and altering the local environment. We will try to answer to questions like: why can a lipophilic substrate be transformed by these catalysts even in an aqueous environment? Why may the pH in the catalytic loci of the nanosystem be different from that of the bulk solution even in the presence of buffers? Why are most of these nanosystems better than monovalent ones?

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Section: Nanocatalysts For the Hydrolysis Of Phosphoric Acid Estersmentioning

confidence: 85%

Hydrolytic Nanozymes

et al. 2020

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“…Scrimin et al developed catalytic NPs with behavior similar to that of natural enzymes and called them nanozymes [62]. For example, they exploited Au NPs as a platform for attaching thiols containing chiral Zn II -binding head groups [61]. The resulting NPs presented chiral bimetallic catalytic sites that exhibited different hydrolytic activities for the enantiomers of a pure RNA model substrate.…”

Section: Asymmetric Catalysismentioning

confidence: 99%

Chirality at the Nanoparticle Surface: Functionalization and Applications

Zafar

Ragusa

2020

Applied Sciences

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Chiral molecules, such as amino acids and carbohydrates, are the building blocks of nature. As a consequence, most natural supramolecular structures, such as enzymes and receptors, are able to distinguish among different orientations in space of functional groups, and enantiomers of chiral drugs usually have different pharmacokinetic properties and physiological effects. In this regard, the ability to recognize a single enantiomer from a racemic mixture is of paramount importance. Alternatively, the capacity to synthetize preferentially one enantiomer over another through a catalytic process can eliminate (or at least simplify) the subsequent isolation of only one enantiomer. The advent of nanotechnology has led to noteworthy improvements in many fields, from material science to nanomedicine. Similarly, nanoparticles functionalized with chiral molecules have been exploited in several fields. In this review, we report the recent advances of the use of chiral nanoparticles grouped in four major areas, i.e., enantioselective recognition, asymmetric catalysis, biosensing, and biomedicine.

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“…We have shown above, for metallomicelles and metallovesicles, that chiral discrimination in the hydrolytic cleavage is feasible. Recently we demonstrated for the first time [73] enantioselectivity in RNA cleavage by a synthetic metallonanoparticle. Thiols containing chiral Zn(II)-binding head groups have been self-assembled on the surface of gold nanoparticles (Figure 9).…”

Section: Metallonanoparticlesmentioning

confidence: 99%

Hydrolytic Metallo-Nanozymes: From Micelles and Vesicles to Gold Nanoparticles

et al. 2016

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Abstract:Although the term nanozymes was coined by us in 2004 to highlight the enzyme-like properties of gold nanoparticles passivated with a monolayer of Zn(II)-complexes in the cleavage of phosphate diesters, systems resembling those metallo-nanoparticles, like micelles and vesicles, have been the subject of investigation since the mid-eighties of the last century. This paper reviews what has been done in the field and compares the different nanosystems highlighting the source of catalysis and frequent misconceptions found in the literature.

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Chiral Nanozymes–Gold Nanoparticle‐Based Transphosphorylation Catalysts Capable of Enantiomeric Discrimination

Cited by 61 publications

References 48 publications

Hydrolytic Nanozymes

Hydrolytic Nanozymes

Chirality at the Nanoparticle Surface: Functionalization and Applications

Hydrolytic Metallo-Nanozymes: From Micelles and Vesicles to Gold Nanoparticles

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