Abstract:Stereochemically inert and positively charged chiral complexes of Co(III) were shown to catalyze the asymmetric epoxidation of chalcones with H 2 O 2 under phase transfer conditions. The reaction products had enantiomeric purities of up to 55%. It was also shown that complex 1a Icatalyzed the coupling reaction of a resulting epoxide with CO 2 (conversion 72%).Enantiomerically enriched α,β-epoxy ketones are versatile chiral building blocks for access to natural compounds and drugs in medicinal chemistry. 1,2 Th… Show more
“…No kinetic resolution of terminal epoxides, assessed by analyzing the enantiomeric purity of the remaining initial epoxides at the later stages of the conversion, was detected. However, in the case of the internal epoxide chalcone oxide 8 g , kinetic resolution did occur and the enantiomeric purity of the remaining epoxide 8 g was 55 % (determined by chiral HPLC) at 60 % conversion . It may be that the positioning of the epoxide by hydrogen bonding to the chiral catalyst was more rigid than for simple epoxides owing to the presence of an additional carbonyl group, also capable of forming hydrogen bonds with the catalyst.…”
Section: Resultsmentioning
confidence: 99%
“…[e] Reaction conditions: neat epoxide, 1 mol % of complex 3 , 50 °C, 5 MPa CO 2 . [f] In 0.1 mL toluene using 10 mol % of the catalyst …”
Section: Resultsmentioning
confidence: 99%
“…[ f] In 0.1 mL toluene using 10 mol %o ft he catalyst. [36] ChemSusChem 2016, 9,216 -222 www.chemsuschem.org…”
Stereochemically inert cationic cobalt(III) complexes were shown to be one-component catalysts for the synthesis of cyclic carbonates from epoxides and carbon dioxide at 50 °C and 5 MPa carbon dioxide pressure. The optimal catalyst possessed an iodide counter anion and could be recycled. A catalytic cycle is proposed in which the ligand of the cobalt complexes acts as a hydrogen-bond donor, activating the epoxide towards ring opening by the halide anion and activating the carbon dioxide for subsequent reaction with the halo-alkoxide. No kinetic resolution was observed when terminal epoxides were used as substrates, but chalcone oxide underwent kinetic resolution.
“…No kinetic resolution of terminal epoxides, assessed by analyzing the enantiomeric purity of the remaining initial epoxides at the later stages of the conversion, was detected. However, in the case of the internal epoxide chalcone oxide 8 g , kinetic resolution did occur and the enantiomeric purity of the remaining epoxide 8 g was 55 % (determined by chiral HPLC) at 60 % conversion . It may be that the positioning of the epoxide by hydrogen bonding to the chiral catalyst was more rigid than for simple epoxides owing to the presence of an additional carbonyl group, also capable of forming hydrogen bonds with the catalyst.…”
Section: Resultsmentioning
confidence: 99%
“…[e] Reaction conditions: neat epoxide, 1 mol % of complex 3 , 50 °C, 5 MPa CO 2 . [f] In 0.1 mL toluene using 10 mol % of the catalyst …”
Section: Resultsmentioning
confidence: 99%
“…[ f] In 0.1 mL toluene using 10 mol %o ft he catalyst. [36] ChemSusChem 2016, 9,216 -222 www.chemsuschem.org…”
Stereochemically inert cationic cobalt(III) complexes were shown to be one-component catalysts for the synthesis of cyclic carbonates from epoxides and carbon dioxide at 50 °C and 5 MPa carbon dioxide pressure. The optimal catalyst possessed an iodide counter anion and could be recycled. A catalytic cycle is proposed in which the ligand of the cobalt complexes acts as a hydrogen-bond donor, activating the epoxide towards ring opening by the halide anion and activating the carbon dioxide for subsequent reaction with the halo-alkoxide. No kinetic resolution was observed when terminal epoxides were used as substrates, but chalcone oxide underwent kinetic resolution.
“…In our earlier work we used the chiral NNO and ONO type ligands based on Schiff bases of chiral diamines (or amino acids) and salicylaldehydes to construct new type of chiral octahedral inert cobalt(III) complexes . These complexes were efficient catalysts for different asymmetric reactions …”
Herein, we report the synthesis and characterizations of chiral copper(II) coordination polymers (CPs) based on Schiff base of (S)‐2‐aminomethylpyrrolidine and salicylaldehyde derivatives. Single crystal X‐ray analysis showed that copper(II) complex is 1D CP, with the repeating units LCu‐OAc (L=ligand) organized in a perpendicular manner, where the copper(II) atoms are six‐coordinated and have a distorted octahedral geometry. Also complex with chlorine counter ion having unusual dimeric structure was synthesized and characterized. It was demonstrated that CPs catalyze the enantioselective Henry reaction with up to 78% ee.
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