Chiral porous organic frameworks and their application in enantioseparation

Zhang, Ying; Jin, Xiaoning; Ma, Xiaofei; Wang, Yong

doi:10.1039/d0ay01831g

Cited by 41 publications

(16 citation statements)

References 144 publications

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“…Further elaboration of these synthetic and post-functionalization methods is beyond the scope of this review. Many other reviews have covered various aspects of COF reticular synthesis and properties in detail [81][82][83][84][85][86][87][88][89][90].…”

Section: Evolution Of Cof Synthesis Through Timementioning

confidence: 99%

Structural Characteristics and Environmental Applications of Covalent Organic Frameworks

et al. 2021

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Covalent organic frameworks (COFs) are emerging crystalline polymeric materials with highly ordered intrinsic and uniform pores. Their synthesis involves reticular chemistry, which offers the freedom of choosing building precursors from a large bank with distinct geometries and functionalities. The pore sizes of COFs, as well as their geometry and functionalities, can be pre-designed, giving them an immense opportunity in various fields. In this mini-review, we will focus on the use of COFs in the removal of environmentally hazardous metal ions and chemicals through adsorption and separation. The review will introduce basic aspects of COFs and their advantages over other purification materials. Various fabrication strategies of COFs will be introduced in relation to the separation field. Finally, the challenges of COFs and their future perspectives in this field will be briefly outlined.

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Section: Evolution Of Cof Synthesis Through Timementioning

confidence: 99%

Structural Characteristics and Environmental Applications of Covalent Organic Frameworks

et al. 2021

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“…The separation properties of CEC are mainly attributed to the noncovalent interactions between analytes and the stationary phase, including hydrophobic, hydrophilic, electron donor-acceptor interaction and size exclusion [3,4]. Development of novel chiral-stationary phases for chiral CEC is an eternal research subject either in chemical industry or pharmaceutical production [5][6][7].…”

Section: Introductionmentioning

confidence: 99%

β‐Cyclodextrin covalent organic framework supported by polydopamine as stationary phases for electrochromatographic enantioseparation

Guan

Huang

et al. 2022

Electrophoresis

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In this work, a new open‐tubular capillary electrochromatography (OT‐CEC) column was prepared using β‐cyclodextrin covalent organic framework (β‐CD COF) as a stationary phase. Polydopamine was used to assist fabrication of β‐CD COF on an inner wall of a fused‐silica capillary. The coating layer on the capillary was characterized by scanning electron microscopy (SEM) and Fourier transform infrared spectroscopy (FTIR). Electroosmotic flow (EOF) was also studied to evaluate the variation of the inner wall of immobilized columns. Furthermore, the chiral separation effectiveness of the fabricated capillary column was evaluated by CEC using enantiomers of several related proton pump inhibitors as model analytes, including omeprazole, lansoprazole, pantoprazole and tenatoprazole. The effects of bonding time and concentration of β‐CD COF, the type, concentration and pH of buffer, applied voltage were investigated to obtain satisfactory enantioselectivity. In the optimum conditions, the enantiomers of four analytes were resolved within 15 min with resolutions of 1.63–2.62. The relative standard deviation values for migration times and resolutions of the analytes representing intraday and interday were less than 6.75% and 4.24%, respectively. The results reveal that β‐CD COF has great potential as chiral‐stationary phases for enantioseparation in CEC.

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“…Exploring the appropriate stationary phases to apply in CEC is the core topic of OT-CEC. Recently, various porous or nanomaterials have been investigated as OT-CEC stationary phases [ 9 , 10 ], such as graphene oxide [ 10 , 11 ], magnetic nanoparticles [ 12 ], metal-organic frameworks (MOFs) [ 6 , 7 , 13 ], porous organic molecular cages [ 14 ] and covalent organic frameworks (COFs) [ [15] , [16] , [17] , [18] , [19] , [20] ]. However, OT columns have a low phase ratio, which may result in poor separation performance.…”

Section: Introductionmentioning

confidence: 99%

In situ synthesis of a spherical covalent organic framework as a stationary phase for capillary electrochromatography

He¹,

Li²,

Hu³

et al. 2022

Journal of Pharmaceutical Analysis

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Chiral porous organic frameworks and their application in enantioseparation

Abstract: Porous organic frameworks (POFs) is a kind of porous material with network structure composed of repeated monomers, which has excellent physical and chemical properties such as large surface area, high...

Cited by 41 publications

References 144 publications

Structural Characteristics and Environmental Applications of Covalent Organic Frameworks

Structural Characteristics and Environmental Applications of Covalent Organic Frameworks

β‐Cyclodextrin covalent organic framework supported by polydopamine as stationary phases for electrochromatographic enantioseparation

In situ synthesis of a spherical covalent organic framework as a stationary phase for capillary electrochromatography

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