Chiral Resolution ofRR,SS-Hydrobenzoin by Liquid Chromatography Using Borate-Cyclodextrin Complexation

Schmid, Martin G.; Härringer, Birgit; Szabó, Klára

doi:10.1002/(sici)1521-4168(19980701)21:7<414::aid-jhrc414>3.0.co;2-n

Cited by 8 publications

(10 citation statements)

References 6 publications

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“…These results indicated that the presence of phosphate buffer in the mobile phase had a little influence on the retention and enantioseparation. In the works by Gübitz and coworkers [13], only a slight enantioseparation for hydrobenzoin was observed when phosphate buffer was used (b-CD as CMPA). The authors also pointed out that no chiral separation was obtained in the absence of borate buffer by CE [14].…”

Section: Effects Of the Amount Of Ch 3 Cn In The Presence Of Phosphatmentioning

confidence: 99%

“…In ref. [13], the authors pointed out that there was no resolution for hydrobenzoin when a b-CD column was tested using borate buffer as a mobile phase [13]. Different synthetic method may be used.…”

Section: Effects Of the Amount Of Ch 3 Cn In The Presence Of Borate Bmentioning

confidence: 99%

“…In the same way, they are used as chiral selectors by means of capillary electrophoresis [10][11][12]. Gübitz and coworkers [13] developed an LC method to separate the enantiomers of hydrobenzoin using b-CD as a mobile phase additive. An excellent enantioseparation was obtained when the mobile phase contained borate buffer, whereas only a slight enantioseparation could be observed when phosphate buffer was used.…”

Section: Introductionmentioning

confidence: 99%

“…The enantioseparation of hydrobenzoin disappeared wholly in the absence of borate using CE [14]. The authors also pointed out that there was no resolution for hydrobenzoin when a b-CD column was tested using borate buffer as a mobile phase [13]. Lin and coworkers investigated the enantioseparation of benzoins by capillary zone electrophoresis with dual cyclodextrin systems and borate complexation.…”

Section: Introductionmentioning

confidence: 99%

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Enantioseparation of Hydrobenzoin and Structurally Related Compounds on β-Cyclodextrin and Hydroxypropyl-β-cyclodextrin Bonded Chiral Stationary Phases

Guo

Xie

et al. 2011

Chromatographia

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A b-cyclodextrin (b-CD) and a hydroxypropylb-cyclodextrin (HP-b-CD) bonded chiral stationary phase (CSP) were prepared. Comparative evaluations of these two CSPs for the enantioseparation of hydrobenzoin, benzoin and a-phenethyl alcohol by reversed-phase liquid chromatography were presented. The effects of buffer composition in the mobile phase on the retention and enantioseparation were investigated. The borate buffer had a significant influence on the retention and enantioseparation of hydrobenzoin. Linear solvent strength retention model was used to fit the chromatographic data. Good linearity existed between the logarithm of retention factor (k) and the volume fraction of organic modifier (u). Another retention model, stoichiometric displacement theory for retention, was also tried to fit the chromatographic data. The results showed that not only acetonitrile, but also water molecules participated in the displacing process of the solute.

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Section: Effects Of the Amount Of Ch 3 Cn In The Presence Of Phosphatmentioning

confidence: 99%

Section: Effects Of the Amount Of Ch 3 Cn In The Presence Of Borate Bmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Enantioseparation of Hydrobenzoin and Structurally Related Compounds on β-Cyclodextrin and Hydroxypropyl-β-cyclodextrin Bonded Chiral Stationary Phases

Guo

Xie

et al. 2011

Chromatographia

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“…It has been reported that ambroxol hydrochloride has been estimated by capillary electrophoresis, [13][14][15] spectrophotometry, 16 gas chromatography, 17,18 liquid chromatography with potentiometric estimation, 19 MS detection, 20 UV detection, [21][22][23][24] RP HPLC, 25,21 Raman spectroscopy, 26 liquid chromatography with roxithromycin 27 and derivative UV and HPLC.…”

mentioning

confidence: 99%

Development and Validation of Simultaneous UV Spectrophotometric Method for the Determination of Levofloxacin and Ambroxol in Tablets

Patil¹,

Pore²

2008

Journal of the Korean Chemical Society

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ABSTRACT. An accurate, specific and precise UV spectrophotometric method was developed for the simultaneous determination of levofloxacin (LFX) and ambroxol (ABX) in pharmaceutical dosage forms. The method involves formation of Q-absorbance equation at 219 (isoabsorptive point) and at 287 nm, using distilled water as a solvent. The linearity for both levofloxacin and ambroxol was in the range of 2-20 µg/ml and 5-50 µg/ml respectively. The % recovery was found to be 100-101% and 99-102% for levofloxacin and ambroxol respectively indicating proposed method is accurate and precise for simultaneous estimation of levofloxacin and ambroxol in tablets.

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Comparative studies on the enantioseparation of hydrobenzoin and structurally related compounds by capillary zone electrophoresis with sulfated β-cyclodextrin as the chiral selector in the presence and absence of borate complexation

Lin

2004

Journal of Chromatography A

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Chiral Resolution ofRR,SS-Hydrobenzoin by Liquid Chromatography Using Borate-Cyclodextrin Complexation

Cited by 8 publications

References 6 publications

Enantioseparation of Hydrobenzoin and Structurally Related Compounds on β-Cyclodextrin and Hydroxypropyl-β-cyclodextrin Bonded Chiral Stationary Phases

Enantioseparation of Hydrobenzoin and Structurally Related Compounds on β-Cyclodextrin and Hydroxypropyl-β-cyclodextrin Bonded Chiral Stationary Phases

Development and Validation of Simultaneous UV Spectrophotometric Method for the Determination of Levofloxacin and Ambroxol in Tablets

Comparative studies on the enantioseparation of hydrobenzoin and structurally related compounds by capillary zone electrophoresis with sulfated β-cyclodextrin as the chiral selector in the presence and absence of borate complexation

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