Chiral ruthenium(II) complex Δ-[Ru(bpy)2(o-FMPIP)] (bpy = bipyridine, o-FMPIP = 2-(2′-trifluoromethyphenyl) imidazo[4,5-f][1,10]phenanthroline) as potential apoptosis inducer via DNA damage

Bai, Man; Yu, Gengnan; Xie, Qiang; Zeng, Zhaolin; Zhang, Yanyang; Zhu, Duo; Mu, Luwen; Qian, Ji; Chang, Boyang; Mei, Wenjie; Guan, Sheng

doi:10.1016/j.ejphar.2019.03.009

Cited by 5 publications

(2 citation statements)

References 35 publications

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“…The development of new antitumor drugs requires understanding the mechanisms of action of new pharmacological candidates, which highlights the importance of elucidating the molecular and biochemical mechanisms involved. Recent studies have shown that some ruthenium complexes target the genomic DNA and may cause cell cycle arrest, ROS-mediated mitochondrial alterations and, finally, cell death by apoptosis 3,[7][8][9] .…”

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confidence: 99%

Ruthenium (II) complex cis-[RuII(ŋ2-O2CC7H7O2)(dppm)2]PF6-hmxbato induces ROS-mediated apoptosis in lung tumor cells producing selective cytotoxicity

Costa

Gonçalves

Borges

et al. 2020

Sci Rep

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Ruthenium complexes have been extensively explored as potential molecules for cancer treatment. Considering our previous findings on the remarkable cytotoxic activity exhibited by the ruthenium (II) complex 3-hydroxy-4-methoxybenzoate (hmxbato)-cis-[RuII(ŋ2-O2CC7H7O2)(dppm)2]PF6 against Leishmania promastigotes and also the similar metabolic characteristics between trypanosomatids and tumor cells, the present study aimed to analyze the anticancer potential of hmxbato against lung tumor cells, as well as the partial death mechanisms involved. Hmxbato demonstrated selective cytotoxicity against A549 lung tumor cells. In addition, this complex at a concentration of 3.8 µM was able to expressively increase the generation of reactive oxygen species (ROS) in tumor cells, causing an oxidative stress that may culminate in: (1) reduction in cellular proliferation; (2) changes in cell morphology and organization patterns of the actin cytoskeleton; (3) cell arrest in the G2/M phase of the cell cycle; (4) apoptosis; (5) changes in the mitochondrial membrane potential and (6) initial DNA damage. Furthermore, we demonstrated that the induction of programmed cell death can occur by the intrinsic apoptotic pathway through the activation of caspases. It is also worth highlighting that hmxbato exhibited predominant actions on A549 tumor cells in comparison to BEAS-2B normal bronchial epithelium cells, which makes this complex an interesting candidate for the design of new drugs against lung cancer.

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confidence: 99%

Ruthenium (II) complex cis-[RuII(ŋ2-O2CC7H7O2)(dppm)2]PF6-hmxbato induces ROS-mediated apoptosis in lung tumor cells producing selective cytotoxicity

Costa

Gonçalves

Borges

et al. 2020

Sci Rep

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“…Diante desde cenário, os complexos de rutênio têm ganhado destaque devido principalmente, suas propriedades favoráveis (JAYAKUMAR et al, 2018;RILAK SIMOVIĆ et al, 2019) e suas diferentes aplicações terapêuticas, incluindo as atividades antitumoral (BAI et al, 2019(BAI et al, , 2019CARNIZELLO et al, 2016;IRACE et al, 2017;JIANG et al, 2019a;LI et al, 2019) e antiparasitária (COSTA et al, 2017(COSTA et al, , 2019MIRANDA et al, 2018 NAVES et al, 2019).…”

Section: Sumáriounclassified

Estudo dos mecanismos de morte induzidos pelo complexo de rutênio hmxbato (cis-[RuII((ŋ2-O2CC7H7O2)(dppm)2]PF6) com atividade contra Leishmania (Leishmania) amazonensis e células tumorais de pulmão – A549

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Cyclometalated Ru(II)-isoquinoline complexes overcome cisplatin resistance of A549/DDP cells by downregulation of Nrf2 via Akt/GSK-3β/Fyn pathway

Chen

Wang

Cai

et al. 2022

Bioorganic Chemistry

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Chiral ruthenium(II) complex Δ-[Ru(bpy)2(o-FMPIP)] (bpy = bipyridine, o-FMPIP = 2-(2′-trifluoromethyphenyl) imidazo[4,5-f][1,10]phenanthroline) as potential apoptosis inducer via DNA damage

Cited by 5 publications

References 35 publications

Ruthenium (II) complex cis-[RuII(ŋ2-O2CC7H7O2)(dppm)2]PF6-hmxbato induces ROS-mediated apoptosis in lung tumor cells producing selective cytotoxicity

Ruthenium (II) complex cis-[RuII(ŋ2-O2CC7H7O2)(dppm)2]PF6-hmxbato induces ROS-mediated apoptosis in lung tumor cells producing selective cytotoxicity

Estudo dos mecanismos de morte induzidos pelo complexo de rutênio hmxbato (cis-[RuII((ŋ2-O2CC7H7O2)(dppm)2]PF6) com atividade contra Leishmania (Leishmania) amazonensis e células tumorais de pulmão – A549

Cyclometalated Ru(II)-isoquinoline complexes overcome cisplatin resistance of A549/DDP cells by downregulation of Nrf2 via Akt/GSK-3β/Fyn pathway

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