Chiral salen - Ni (II) based spherical porous silica as platform for asymmetric transfer hydrogenation reaction and synthesis of potent drug intermediate montekulast

Application of chiral recyclable catalysts in asymmetric catalysis

“…Silica, known for its stability and adaptability to various applications, has emerged as a promising support material in heterogeneous systems. 120 Two approaches have been employed for the development of silica-supported chiral catalysts: post-grafting strategy and post-modification and co-condensation strategy.…”

Photocatalytic Chemoselective Transfer Hydrogenation of Quinolines to Tetrahydroquinolines on Hierarchical NiO/In2O3–CdS Microspheres

“…More interestingly, our experimental and density functional theory (DFT) studies indicate that NiO serves as the active sites to activate benzyl alcohol to active hydrogen more effectively compared with metallic Ni. To the best of our knowledge, this is the first example for NiO acting as photocatalytically active sites to effectively activate benzyl alcohol, which breaks through the traditional concept that the metallic Ni acts as the photocatalytically active site for benzyl alcohol activation. − This work not only reports an efficient heterogeneous photocatalyst for the chemoselective TH reaction of quinolines to tetrahydroquinolines, but also paves a way for designing other photocatalytic systems toward the chemoselective TH reaction of diverse N-heterocycles.…”

Asymmetric hydrogenation using a covalently immobilized Ru-BINOL-AP@MSNs catalyst

“…24,25 Mesoporous amorphous silica nanoparticles (MSNs) have been shown to be useful support materials because they can be obtained in large quantities, possess a large surface-to-volume ratio, are stable at high temperatures and pH, and can be functionalized in a number of different ways. [26][27][28][29][30] In light of the rising appreciation for MSNs as promising platforms, the proposed work aimed to develop a state-of-the-art method to synthesize an exceedingly competent and enantioselective system by grafting the Ru(III) (S) BINOL moiety onto MSNs. It demonstrated unique activity in stereoselective transfer hydrogenation, with 84.38% conversion and enantioselectivity 490% for the R-isomer.…”